Действие обусловлено ингибированием бактериальных топоизомер... Инструкция
Показания к применению
Острый синусит, обострение хронического бронхита, внебольничная пневмония, инфекции кожи и мягких тканей, осложненные интраабдоминальные инфекции, неосложненные инфекции органов малого таза.
Противопоказания
Повышенная чувствительность к моксифлоксацину, другим хинолонам и компонентам препарата, эпилепсия, тяжелая диарея, поражение сухожилий при ранее проводившемся лечении хинолонами, синдром врожденного или приобретенного удлинения интервала Q-T, выраженная брадикардия, выраженная сердечная недостаточность со снижением фракции выброса левого желудочка, ...
Таблетки Ротомокс - противомикробный (бактерицидный) препарат. Показан для лечения инфекций, вызванных чувствительными штаммами микроорганизмов, у взрослых пациентов.
Фармакологические свойства
Действие обусловлено ингибированием бактериальных топоизомеразы II (ДНК-гиразы) и топоизомеразы IV, что приводит к нарушению синтеза ДНК микробной клетки. Эффективен в отношении бактерий, резистентных к бета-лактамным и макролидным антибиотикам. Отсутствует перекрестная резистентность с пенициллинами, цефалоспоринами, аминогликозидами, макролидами и тетрациклинами. Общая частота развития резистентности низкая. Исследования показали, что резистентность к моксифлоксацину развивается медленно в результате ряда последовательных мутаций. Между препаратами из группы фторхинолонов развивается перекрестная резистентность. Однако некоторые грамположительные и анаэробные микроорганизмы, устойчивые к другим фторхинолонам, чувствительны к моксифлоксацину.
Показания к применению
Острый синусит, обострение хронического бронхита, внебольничная пневмония, инфекции кожи и мягких тканей, осложненные интраабдоминальные инфекции, неосложненные инфекции органов малого таза.
Противопоказания
Повышенная чувствительность к моксифлоксацину, другим хинолонам и компонентам препарата, эпилепсия, тяжелая диарея, поражение сухожилий при ранее проводившемся лечении хинолонами, синдром врожденного или приобретенного удлинения интервала Q-T, выраженная брадикардия, выраженная сердечная недостаточность со снижением фракции выброса левого желудочка, желудочковые аритмии (при применении хинолонов в анамнезе), одновременный прием препаратов, удлиняющих интервал Q-Т (антиаритмические препараты класса IA, III), выраженный электролитный дисбаланс (некорректируемая гипокалиемия), тяжелая печеночная недостаточность (класс С по Чайлд-Пью).
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Рекомендуемый режим дозирования: 400 мг (1 таблетка) 1 раз в день. Таблетку следует проглатывать целиком, не разжевывая, запивая достаточным количеством воды, вне зависимости от приема пищи. Продолжительность лечения определяется локализацией и тяжестью инфекции, а также клиническим эффектом. Обострение хронического бронхита: 5 дней. Острый синусит: 7 дней. Неосложненные инфекции кожи и мягких тканей: 7 дней. Внебольничная пневмония: 7-14 дней. Осложненные инфекции кожи и подкожных структур: 7-21 день. Осложненные интраабдоминальные инфекции: 5-14 дней. Неосложненные инфекции органов малого таза: 14 дней. Не следует превышать рекомендуемую продолжительность лечения.
Побочное действие
Аллергические реакции, боль в животе, тошнота, диарея, головокружение, бессонница или сонливость, расстройство зрения (нечеткость, снижение остроты зрения), удлинение интервала Q-T (часто у больных с сопутствующей гипокалиемией), ощущение сердцебиения, неспецифические аритмии, артралгия, миалгия, вагинальный кандидоз, периферические отеки.
Передозировка
Лечение: симптоматическая поддерживающая терапия с ЭКГ-мониторингом.
Особые указания
Препарат может нарушать способность пациента заниматься потенциально опасными видами деятельности, требующими повышенного внимания и быстроты психомоторных реакций.
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