Вазонит Таблетки, 20 шт, 600 мг, для приема внутрь, для взрослых, пролонгированного действия

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Концентрация метаболитов I и V в плазме соответственно в 5 и 8 раз выше, чем пентоксифиллина. При приеме внутрь таблеток Вазонита максимальная концентрация пентоксифиллина и его активных метаболитов в плазме крови достигается через 3–4 ч и сохраняется на терапевтическом уровне около 12 ч. Препарат выводится преимущественно (94%) почками в виде метаболитов. Выделяется с грудным молоком. При тяжелом нарушении функции почек выведение метаболитов замедлено. При нарушении функции печени отмечается удлинение периода полувыведения и повышение биодоступности."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Нарушение периферического кровообращения на фоне атеросклеротических, диабетических и воспалительных процессов (в том числе при «перемежающейся» хромоте, обусловленной атеросклерозом, диабетической ангиопатией, облитерирующим эндартериитом); "}},{"type":"paragraph","data":{"text":"Острые и хронические нарушения мозгового кровообращения ишемического генеза; "}},{"type":"paragraph","data":{"text":"Симптоматическое лечение последствий нарушения мозгового кровообращения атеросклеротического генеза (нарушение концентрации внимания, головокружение, ухудшение памяти);"}},{"type":"paragraph","data":{"text":"Атеросклеротическая и дисциркуляторная энцефалопатия; ангиопатии (парестезии, болезнь Рейно); "}},{"type":"paragraph","data":{"text":"Трофические нарушения тканей вследствие нарушения артериальной или венозной микроциркуляции (трофические язвы, посттромбофлебитический синдром, обморожения, гангрена); "}},{"type":"paragraph","data":{"text":"Нарушения кровообращения в сосудах глаза (острая и хроническая недостаточность кровообращения  в сетчатой или в сосудистой оболочке глаза); "}},{"type":"paragraph","data":{"text":"Нарушения функции среднего уха сосудистого генеза, сопровождающиеся тугоухостью. "}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к пентоксифиллину, другим производным метилксантина или другим компонентам, входящим в состав препарата;"}},{"type":"paragraph","data":{"text":"Острый инфаркт миокарда; "}},{"type":"paragraph","data":{"text":"Массивные кровотечения; "}},{"type":"paragraph","data":{"text":"Кровоизлияние в сетчатку глаза; "}},{"type":"paragraph","data":{"text":"Острый геморрагический инсульт; "}},{"type":"paragraph","data":{"text":"Беременность; "}},{"type":"paragraph","data":{"text":"Период кормления грудью;"}},{"type":"paragraph","data":{"text":"Возраст до 18 лет (эффективность и безопасность не установлены). "}}]},{"name":"С осторожностью","slug":"cautions","id":14,"body":[{"type":"paragraph","data":{"text":"Атеросклероз церебральных и/или коронарных сосудов, особенно в случаях артериальной гипотензии и нарушений ритма сердца; хроническая сердечная недостаточность, печеночная недостаточность, почечная недостаточность (клиренс креатинина менее 30 мл/мин. – риск кумуляции и повышенный риск развития побочных эффектов), язвенная болезнь желудка и двенадцатиперстной кишки, недавно перенесенное хирургическое вмешательство (риск возникновения кровотечений), повышенная склонность к кровоточивости, например, при применении антикоагулянтов или при нарушении свертывающей системы крови (риск развития более тяжелых кровотечений). "}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказан."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки Вазонит следует принимать внутрь, не разжевывая, запивая достаточным количеством жидкости, желательно после еды. Препарат обычно назначают по 1 таблетке 600 мг 2 раза в сутки (утром и вечером), максимальная суточная доза 1200 мг. Длительность лечения и режим дозирования препаратом Вазонит устанавливаются врачом индивидуально, в зависимости от клинической картины заболевания и получаемого терапевтического эффекта. У больных с хронической почечной недостаточностью (клиренс креатинина менее 30 мл/мин) суточную дозу препарата уменьшают до 600 мг. "}},{"type":"paragraph","data":{"text":"Уменьшение дозы, с учетом индивидуальной переносимости, необходимо у пациентов с тяжелыми нарушениями функции печени. "}},{"type":"paragraph","data":{"text":"Лечение может быть начато малыми дозами у пациентов с низким артериальным давлением, а также у пациентов, находящихся в группе риска ввиду возможного снижения артериального давления (пациенты с тяжелой формой ишемической болезни сердца или с гемодинамически значимыми стенозами сосудов головного мозга). В этих случаях дозу можно увеличивать только постепенно. "}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы: головная боль, головокружение, тревожность, нарушения сна, судороги, встречаются случаи развития асептического менингита. Со стороны кожных покровов и подкожно-жировой клетчатки: гиперемия кожи лица, «приливы» крови к коже лица и верхней части грудной клетки, отеки, повышенная ломкость ногтей. "}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: сухость во рту, чувство давления и переполнения в области желудка, снижение аппетита, тошнота, рвота, диарея, атония кишечника, обострение холецистита, холестатический гепатит. "}},{"type":"paragraph","data":{"text":"Со стороны органа зрения: нарушение зрения, скотома. Со стороны сердечно-сосудистой системы: тахикардия, аритмия, кардиалгия, прогрессирование стенокардии, снижение артериального давления. "}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения и системы гемостаза: в редких случаях могут возникать кровотечения (из слизистых оболочек, сосудов кожи, желудка, кишечника), а также тромбоцитопения, лейкопения, панцитопения, гипофибриногенемия, апластическая анемия. В связи с этим при лечении препаратом Вазонит необходимо проводить регулярный контроль картины периферической крови. Аллергические реакции: кожный зуд, гиперемия кожи, крапивница, ангионевротический отек, анафилактический шок. "}},{"type":"paragraph","data":{"text":"Лабораторные показатели: повышение активности «печеночных» трансаминаз: аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (АСТ), а также лактатдегидрогеназы (ЛДГ) и щелочной фосфатазы. "}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: слабость, головокружение, тахикардия, сонливость, выраженное снижение артериального давления, покраснение кожных покровов, потеря сознания, повышение температуры тела (озноб), арефлексия, тонико-клонические судороги, признаки желудочно-кишечного кровотечения (рвота типа «кофейной гущей»). "}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка с последующим приемом внутрь активированного угля. В случае рвоты со следами крови промывание желудка недопустимо. В дальнейшем лечение симптоматическое, направленное на поддержание функции дыхания и артериального давления. При судорогах – диазепам."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Пентоксифиллин может усиливать действие лекарственных средств, влияющих на свертывающую систему крови (непрямые и прямые антикоагулянты, тромболитики), антибиотиков (в том числе цефалоспоринов – цефамандола, цефоперазона, цефотетана), вальпроевой кислоты. Увеличивает эффективность гипотензивных средств, инсулина и гипогликемических средств для приема внутрь. Циметидин повышает концентрацию пентоксифиллина в плазме крови (риск возникновения побочных эффектов). "}},{"type":"paragraph","data":{"text":"Совместное применение с другими ксантинами может приводить к чрезмерному нервному возбуждению. У некоторых пациентов одновременный прием пентоксифиллина и теофиллина может привести к увеличению концентрации теофиллина (риск побочных эффектов, связанных с теофиллином). "}}]},{"id":9,"name":"Особые указания","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Больные с выраженными нарушениями функции почек при приеме Вазонит нуждаются в особенно тщательном врачебном наблюдении. В случае если в период применения препарата у больных возникают кровоизлияния в сетчатую оболочку глаза, то препарат немедленно отменяют. Лечение следует проводить под контролем артериального давления. У больных с низким и нестабильным артериальным давлением вводимая доза должна быть уменьшена. У больных сахарным диабетом, принимающих гипогликемические средства, применение в больших дозах может вызвать гипогликемию (требуется коррекция дозы). При применении одновременно с антикоагулянтами необходимо следить за показателями свертывающей системы крови, в т.ч. международным нормализованным отношением (МНО). У пациентов, перенесших недавно хирургическое вмешательство, необходим систематический контроль гемоглобина и гематокрита. У пожилых людей может потребоваться уменьшение дозы (повышение биодоступности и снижение скорости выведения). Курение может снижать терапевтическую эффективность препарата. "}},{"type":"paragraph","data":{"text":"Во время приема препарата не рекомендуется употребление спиртных напитков."}}],"slug":""},{"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","id":16,"body":[{"type":"paragraph","data":{"text":"Из-за возможного появления головокружения рекомендуется осторожность при управлении транспортными средствами и при обслуживании сложных механизмов. "}}]},{"name":"Форма выпуска","slug":"","id":17,"body":[{"type":"paragraph","data":{"text":"Продолговатые двояковыпуклые таблетки, покрытые пленочной оболочкой белого цвета, с риской с обеих сторон. "}},{"type":"paragraph","data":{"text":"Ядро таблетки белого цвета."}}]},{"name":"Условия хранения","slug":"storage","id":18,"body":[{"type":"paragraph","data":{"text":"В сухом защищенном от света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте. "}}]},{"name":"Срок годности","slug":"expiry_date","id":19,"body":[{"type":"paragraph","data":{"text":"5 лет. Не использовать по истечении срока годности. "}}]},{"name":"Условия отпуска","slug":"release_condition","id":20,"body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"name":"Производитель","slug":"","id":21,"body":[{"type":"paragraph","data":{"text":"G.L. PHARMA. Страна производства: Австрия."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Фармакодинамика Производное ксантина. Улучшает микроциркуляцию в зонах нарушенного кровоснабжения. Улучшает реологические свойства крови (текучесть) за счет воздействия на патологически измененную деформируемость эритроцитов, повышает эластичность мембран эритроцитов, ингибирует агрегацию эритроцитов и тромбоцитов и снижает повышенную вязкость крови. Механизм действия связан с угнетением фосфодиэстеразы и накоплением циклического аденозинмонофосфата (цАМФ) в клетках гладкой мускулатуры сосудов и в форменных элементах крови. Пентоксифиллин тормозит агрегацию эритроцитов и тромбоцитов, снижает уровень фибриногена в плазме крови и усиливает фибринолиз, что уменьшает вязкость крови и улучшает ее реологические свойства. Улучшает снабжение тканей кислородом в зонах нарушенного кровообращения, в частности, в конечностях, центральной нервной системе, и, в меньшей степени, в почках. При окклюзионном поражении периферических артерий («перемежающейся» хромоте) приводит к увеличению дистанции ходьбы, устранению ночных судорог икроножных мышц, уменьшению болей в покое. При нарушении мозгового кровообращения улучшает симптоматику. Оказывая слабое миотропное вазодилатирующее действие, несколько снижает общее периферическое сосудистое сопротивление и незначительно расширяет коронарные сосуды. Фармакокинетика После приема внутрь пентоксифиллин практически полностью всасывается из желудочно-кишечного тракта. Пролонгированная форма обеспечивает непрерывное высвобождение и его равномерную абсорбцию. Пентоксифиллин подвергается метаболизму в печени при «первом прохождении», в результате чего образуется два фармакологически активных метаболита: 1-5-гидроксигексил-3,7-диметилксантин (метаболит I) и 1-3-карбоксипропил-3,7-диметилксантин (метаболит V). Концентрация метаболитов I и V в плазме соответственно в 5 и 8 раз выше, чем пентоксифиллина. При приеме внутрь таблеток Вазонита максимальная концентрация пентоксифиллина и его активных метаболитов в плазме крови достигается через 3–4 ч и сохраняется на терапевтическом уровне около 12 ч. Препарат выводится преимущественно (94%) почками в виде метаболитов. Выделяется с грудным молоком. При тяжелом нарушении функции почек выведение метаболитов замедлено. При нарушении функции печени отмечается удлинение периода полувыведения и повышение биодоступности.","substance":[{"id":174,"title":"Пентоксифиллин","title_latin":"Pentoxyphyllinum","slug":"pentoksifillin_174"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Вазонит - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/69427/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/69427/share_default/"}},"diseases":[{"id":"470","title":"Расстройства личности и поведения, обусловленные болезнью, повреждением или дисфункцией головного мозга","slug":"470-rasstroystva_lichnosti_i_povedeniya_obuslovlennye_boleznyu_povrezhdeniem_ili_disfunktsiey_golovnogo_mozga"},{"id":"557","title":"Преходящие транзиторные церебральные ишемические приступы [атаки] и родственные 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