Гатифлоксацин - 8-метоксифторхинолон с замещением 3-метилпип... Инструкция
Показания к применению
— лечение бактериальных конъюнктивитов, вызванных чувствительными к препарату возбудителями.
Противопоказания
Гиперчувствительность к гатифлоксацину, другим хинолонам, а также другим компонентам препарата
Детский возраст до 1 года. С осторожностью:
У больных, получающих препараты хинолонового ряда системного действия, включая гатифлоксацин. У данной категории больных отмечены серьезные, и, в некоторых случаях с летальным исходом, реакции гиперчувствительности (анафилактические реакции), в ряде случаев после первого введения препарата. Отдельные реакции сопровождались сердечно-сосудистой недостаточностью, потерей сознания, ангионевротическим отеком (включая отек гортани, глотки или лица), обструкцией дыхательных путей, одышкой, зудом и крапивницей
Гатифлоксацин - 8-метоксифторхинолон с замещением 3-метилпиперазинилом в положении С7. Антибактериальное действие гатифлоксацииа обусловлено ингибированием ДНК-гиразы и топоизомеразы IV. ДНК-гираза представляет собой фермент, участвующий в репликации, транскрипции и репарации ДНК бактерий. Топоизомераза IV - фермент, играющий ключевую роль в разделении хромосомной ДНК во время деления бактериальной клетки. Механизм действия фторхинолонов, включая гатифлоксацин, отличается от механизма действия антибактериальных препаратов группы аминогликозидов, макролидов и тетрациклинов, поэтому гатифлоксацин может быть активен в отношении патогенных бактерий, которые устойчивы к перечисленным выше антибиотикам, а они, в свою очередь, могут быть активны в отношении патогенных бактерий, устойчивых к гатифлоксацину. Между гатифлоксанином и перечисленными выше антибиотиками перекрестная резистентность не установлена. В исследованиях in vitro продемонстрировано, что резистентность к гатифлоксацину развивается вследствие многоступенчатых мутаций и встречается с частотой 1× .107-1× .1010. Гатифлоксацин активен в отношении большинства перечисленных ниже штаммов бактерий, как in vitro, так и при клиническом применении. Аэробные грамположительные бактерии: Corynebacterium propinquum, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mitis, Streptococcus pneumoniae. Аэробные грамотрицателъпые бактерии: Haemophilus influenzae.
Показания к применению
— лечение бактериальных конъюнктивитов, вызванных чувствительными к препарату возбудителями.
Противопоказания
Гиперчувствительность к гатифлоксацину, другим хинолонам, а также другим компонентам препарата
Детский возраст до 1 года. С осторожностью:
У больных, получающих препараты хинолонового ряда системного действия, включая гатифлоксацин. У данной категории больных отмечены серьезные, и, в некоторых случаях с летальным исходом, реакции гиперчувствительности (анафилактические реакции), в ряде случаев после первого введения препарата. Отдельные реакции сопровождались сердечно-сосудистой недостаточностью, потерей сознания, ангионевротическим отеком (включая отек гортани, глотки или лица), обструкцией дыхательных путей, одышкой, зудом и крапивницей
Беременность и период грудного вскармливания
У пациентов, имеющих в анамнезе аллергические реакции на другие препараты для местного применения, содержащие гатифлоксацин. Имеются крайне редкие сведения о развитии синдрома Стивена-Джонсона после местного применения гатифлоксацина. При первых признаках аллергических реакций следует немедленно прекратить прием препарата
Применение при беременности и в период грудного вскармливания
В связи с отсутствием адекватных и строго контролируемых исследований у беременных, Зимар при беременности следует применять с осторожностью, и только в случае, если ожидаемая польза для матери превышает потенциальный риск для плода. Подтверждено, что при местном применении гатифлоксацина в виде глазных капель, его системная концентрация в плазме крови низкая, поэтому не предполагается влияние на детей, находящихся на грудном вскармливании. Тем не менее, при назначении препарата Зимар в период лактации грудное вскармливание следует прекратить на период лечения в связи с тем, что экскреция препарата в грудное молоко при местном применении не изучалась.
Способ применения и дозы
Местно. Препарат закапывают в период бодрствования. 1-й и 2-й день закапывают по 1 капле в пораженный глаз каждые 2 часа, до 8 раз в день. С 3 по 7 день закапывают по 1 капле до 4-х раз в день.
Побочное действие
При применении препарата возможно развитие следующих неблагоприятных побочных реакций с указанной частотой развития - очень часто (>10%), часто (>1%, меньше 10%), нечасто (>0,1%, меньше 1%) . редко (>0,01%, меньше 0,1%), очень редко ( меньше 0,01%). Со стороны органа зрения Часто: раздражение конъюнктивы, повышенное слезотечение, кератит, папиллярный конъюнктивит, хемоз. кровоизлияние в конъюнктиву, сухость слизистой оболочки глаз (синдром «сухого глаза»), выделения из глаз, раздражение глаз, боль в глазах, отек век, покраснение глаз, снижение остроты зрения. Со стороны нервной системы Часто: головная боль Со стороны обмена веществ и питания Часто: изменение вкусовых ощущений В постмаркетинговый период были получены сообщения о следующих нежелательных реакциях препарата Зимар (частота не известна). Со стороны органа зрения: блефарит, гиперемия глаз и конъюнктивы, нарушение четкости зрения, зуд в области глаз, отек в области глаз (включая отек роговицы и конъюнктивы), раздражение глаз, боль в глазах. Со стороны пищеварительной системы: тошнота. Со стороны иммунной системы: гиперчувствительность, анафилактические реакции и ангионевротический отек (включая отек гортани, полости рта и лица). Со стороны дыхательной системы, органов грудной клетки и средостения: диспноэ. Со стороны кожи и подкожных тканей: зуд (включая генерализованный зуд), сыпь, крапивница.
Особые указания
При применении препарата возможно развитие следующих неблагоприятных побочных реакций с указанной частотой развития - очень часто (>10%), часто (>1%, меньше 10%), нечасто (>0,1%, меньше 1%) . редко (>0,01%, меньше 0,1%), очень редко ( меньше 0,01%). Со стороны органа зрения Часто: раздражение конъюнктивы, повышенное слезотечение, кератит, папиллярный конъюнктивит, хемоз. кровоизлияние в конъюнктиву, сухость слизистой оболочки глаз (синдром «сухого глаза»), выделения из глаз, раздражение глаз, боль в глазах, отек век, покраснение глаз, снижение остроты зрения. Со стороны нервной системы Часто: головная боль Со стороны обмена веществ и питания Часто: изменение вкусовых ощущений В постмаркетинговый период были получены сообщения о следующих нежелательных реакциях препарата Зимар (частота не известна). Со стороны органа зрения: блефарит, гиперемия глаз и конъюнктивы, нарушение четкости зрения, зуд в области глаз, отек в области глаз (включая отек роговицы и конъюнктивы), раздражение глаз, боль в глазах. Со стороны пищеварительной системы: тошнота. Со стороны иммунной системы: гиперчувствительность, анафилактические реакции и ангионевротический отек (включая отек гортани, полости рта и лица). Со стороны дыхательной системы, органов грудной клетки и средостения: диспноэ. Со стороны кожи и подкожных тканей: зуд (включая генерализованный зуд), сыпь, крапивница.
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Гатифлоксацин активен в отношении большинства перечисленных ниже штаммов бактерий, как in vitro, так и при клиническом применении. Аэробные грамположительные бактерии: Corynebacterium propinquum, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mitis, Streptococcus pneumoniae. Аэробные грамотрицателъпые бактерии: Haemophilus influenzae."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"— лечение бактериальных конъюнктивитов, вызванных чувствительными к препарату возбудителями."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Гиперчувствительность к гатифлоксацину, другим хинолонам, а также другим компонентам препарата","Детский возраст до 1 года. С осторожностью:","У больных, получающих препараты хинолонового ряда системного действия, включая гатифлоксацин. У данной категории больных отмечены серьезные, и, в некоторых случаях с летальным исходом, реакции гиперчувствительности (анафилактические реакции), в ряде случаев после первого введения препарата. Отдельные реакции сопровождались сердечно-сосудистой недостаточностью, потерей сознания, ангионевротическим отеком (включая отек гортани, глотки или лица), обструкцией дыхательных путей, одышкой, зудом и крапивницей","Беременность и период грудного вскармливания","У пациентов, имеющих в анамнезе аллергические реакции на другие препараты для местного применения, содержащие гатифлоксацин. Имеются крайне редкие сведения о развитии синдрома Стивена-Джонсона после местного применения гатифлоксацина. 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Со стороны дыхательной системы, органов грудной клетки и средостения: диспноэ. Со стороны кожи и подкожных тканей: зуд (включая генерализованный зуд), сыпь, крапивница."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При применении препарата возможно развитие следующих неблагоприятных побочных реакций с указанной частотой развития - очень часто (\u003e10%), часто (\u003e1%, меньше 10%), нечасто (\u003e0,1%, меньше 1%) . редко (\u003e0,01%, меньше 0,1%), очень редко ( меньше 0,01%). Со стороны органа зрения Часто: раздражение конъюнктивы, повышенное слезотечение, кератит, папиллярный конъюнктивит, хемоз. кровоизлияние в конъюнктиву, сухость слизистой оболочки глаз (синдром «сухого глаза»), выделения из глаз, раздражение глаз, боль в глазах, отек век, покраснение глаз, снижение остроты зрения. 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