Взрослые (старше 18 лет); первичная гиперхолестеринемия и смешанная дислипидемия (тип IIа и IIb по классификации Фредриксона) в сочетании с диетотерапией; коронарный атеросклероз у больных ишемической болезнью сердца и первичной гиперхолестеринемией, в том числе незначительно выраженной (для замедления прогрессирования заболевания).
Действующее вещество: Флувастатин; Концентрация действующего вещества (мг): 80 мг
Показания к применению
Взрослые (старше 18 лет); первичная гиперхолестеринемия и смешанная дислипидемия (тип IIа и IIb по классификации Фредриксона) в сочетании с диетотерапией; коронарный атеросклероз у больных ишемической болезнью сердца и первичной гиперхолестеринемией, в том числе незначительно выраженной (для замедления прогрессирования заболевания).
вторичная профилактика основных серьезных сердечно-сосудистых событий (внезапная сердечная смерть, перенесенный инфаркт миокарда и коронарная реваскуляризация) у пациентов с ишемической болезнью сердца после проведения чрескожной транслюминальной баллонной ангионеопластики.
Дети и подростки(старше 9 лет); гетерозиготная семейная гиперхолестеринемия в сочетании с диетотерапией.
Противопоказания
Повышенная чувствительность к флувастатину или любому неактивному ингредиенту препарата.
Активное заболевание печени или стойкое повышение концентрации сывороточных трансаминаз неясной этиологии.
Беременность, период кормления грудью.
Способ применения и дозы
Таблетки Лескол Форте можно принимать один раз в сутки вне зависимости от приема пищи. Лескол Форте следует проглатывать целиком, запивая стаканом воды. Существенных различий в гиполипидемическом действии флувастатина при назначении с приемом пищи или через 4 часа после него не наблюдалось. Поскольку флувастатин не взаимодействует с веществами, являющимися субстратами для изофермента CYP3A4, не ожидается его взаимодействия с грейпфрутовым соком.; Не выявлено снижения гиполипидемического действия флувастатина при назначении его во время или через 4 часа после вечернего приема пищи.; Поскольку максимальное гиполипидемическое действие препарата развивается к 4 неделе, первый пересмотр дозы препарата проводят в зависимости от достигнутого эффекта, с интервалом не менее 4-х недель. Терапевтический эффект Лескола Форте сохраняется при его длительном применении.; Перед началом лечения Лесколом Форте больного нужно перевести на стандартную гипохолестериновую диету. Диету необходимо соблюдать и во время всего периода лечения.; Начальная рекомендуемая доза составляет 80 мг (1 таблетка Лескола Форте 80 мг) 1 раз в сутки. В легких случаях заболевания может быть достаточной доза флувастатина 20 мг (1 капсула Лескола 20 мг). Начальную дозу следует подбирать индивидуально, с учетом исходного уровня холестерина/ЛПНП и поставленной цели терапии.; Для пациентов с коронарной болезнью сердца после ангионеопластической операции рекомендуемая начальная доза составляет 80 мг в сутки.; Лескол Форте эффективен при применении в качестве монотерапии. Есть данные, подтверждающие эффективность и безопасность флувастатина при совместном применении с никотиновой кислотой, холестирамином или фибратами.; Дети и подростки младше 18 лет.; Детям и подросткам старше 9 лет в течении 6 месяцев до начала терапии Лесколом Форте и во время всего периода лечения следует придерживаться стандартной гипохолестериновой диеты.; Рекомендуемая начальная доза составляет 80 мг (1 таблетка Лескола Форте по 80 мг) 1 раз в сутки. В легких случаях заболевания может быть достаточной доза флувастатина 20 мг (1 капсула Лескола 20 мг). Начальные дозы должны быть подобраны индивидуально в соответствии с базовым уровнем Хс-ЛПНП и целями лечения.; Применение флувастатина одновременно с никотиновой кислотой, колестирамином или фибратами у детей и подростков не изучалось.; Больные с нарушением функции почек; Поскольку флувастатин выводится в основном печенью и лишь менее 6% поступившей в организм дозы экскретируется с мочой, у больных с нарушениями функции почек любой степени тяжести нет необходимости проводить коррекцию дозы препарата.; Больные с нарушением функции печени; Противопоказано применение Лескола Форте при активном заболевании печени или стойком повышении концентрации сывороточных трансаминаз неясной этиологии.; Больные пожилого возраста; Эффективность и хорошая переносимость флувастатина была продемонстрирована для пациентов как старше 65 лет, так и моложе этого возраста. В возрастной группе старше 65 лет ответная реакция на лечение была более выраженной, при этом каких-либо данных, свидетельствующих о худшей переносимости, получено не было. Таким образом, нет необходимости изменения дозы Лескола Форте с учетом возраста.
Побочное действие
Приведенные ниже нежелательные явления перечислены по частоте, начиная с самых частых. Частоту встречаемости нежелательных реакций оценивали следующим образом: возникающие "очень часто" - ≥1/10, "часто" - ≥1/100 ≤1/10, "иногда" - ≥1/1000 ≤1/100, "редко" - ≥1/10 000 ≤1/1000, "очень редко" - ≤1/10000, включая отдельные сообщения. В пределах каждой группы, выделенной по частоте встречаемости, побочные реакции распределены в порядке уменьшения их важности.; Среди наблюдаемых побочных эффектов препарата наиболее часто отмечали незначительные симптомы со стороны желудочно-кишечного тракта, бессонницу и головную боль.; Со стороны системы кроветворения и лимфатической системы: очень редко — тромбоцитопения.; Психические нарушения: часто -бессонница.; Со стороны нервной системы: часто - головная боль; очень редко - парестезии, дизестезия, гипестезия, возможно связанные с основным заболеванием.; Со стороны сосудистой системы: очень редко - васкулит.; Со стороны желудочно-кишечного тракта: часто - диспепсия, боли в животе, тошнота; очень редко - панкреатит.; Со стороны печени: очень редко - гепатит.; Со стороны кожи и подкожной клетчатки: редко - реакции повышенной чувствительности, такие как сыпь, крапивница; очень редко - другие кожные реакции (экзема, дерматит, буллезная экзантема), отек лица, ангионевротический отек.; Со стороны скелетно-мышечной системы: редко - миалгия, мышечная слабость, миопатия; очень редко - миозит, рабдомиолиз, волчаночноподобные реакции.; Лабораторные показатели; Повышение концентраций трансаминаз в сыворотке крови до значений, более чем в 3 раза превышающих верхнюю границу нормы (1-2%).; Выраженное повышение уровней креатинфосфокиназы (КФК) - более чем 5-кратное превышение верхней границы нормы (0,3-1%).; Профиль безопасности применения флувастатина у детей и подростков с гетерозиготнойсемейной гиперхолестеринемией, который оценивался в ходе двух клинических исследований, не отличался от установленного для взрослых. В обоих клинических исследованиях у детей и подростков отмечались нормальные процессы роста и полового развития.
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Лескол Форте следует проглатывать целиком, запивая стаканом воды. Существенных различий в гиполипидемическом действии флувастатина при назначении с приемом пищи или через 4 часа после него не наблюдалось. Поскольку флувастатин не взаимодействует с веществами, являющимися субстратами для изофермента CYP3A4, не ожидается его взаимодействия с грейпфрутовым соком.; Не выявлено снижения гиполипидемического действия флувастатина при назначении его во время или через 4 часа после вечернего приема пищи.; Поскольку максимальное гиполипидемическое действие препарата развивается к 4 неделе, первый пересмотр дозы препарата проводят в зависимости от достигнутого эффекта, с интервалом не менее 4-х недель. Терапевтический эффект Лескола Форте сохраняется при его длительном применении.; Перед началом лечения Лесколом Форте больного нужно перевести на стандартную гипохолестериновую диету. Диету необходимо соблюдать и во время всего периода лечения.; Начальная рекомендуемая доза составляет 80 мг (1 таблетка Лескола Форте 80 мг) 1 раз в сутки. В легких случаях заболевания может быть достаточной доза флувастатина 20 мг (1 капсула Лескола 20 мг). Начальную дозу следует подбирать индивидуально, с учетом исходного уровня холестерина/ЛПНП и поставленной цели терапии.; Для пациентов с коронарной болезнью сердца после ангионеопластической операции рекомендуемая начальная доза составляет 80 мг в сутки.; Лескол Форте эффективен при применении в качестве монотерапии. Есть данные, подтверждающие эффективность и безопасность флувастатина при совместном применении с никотиновой кислотой, холестирамином или фибратами.; Дети и подростки младше 18 лет.; Детям и подросткам старше 9 лет в течении 6 месяцев до начала терапии Лесколом Форте и во время всего периода лечения следует придерживаться стандартной гипохолестериновой диеты.; Рекомендуемая начальная доза составляет 80 мг (1 таблетка Лескола Форте по 80 мг) 1 раз в сутки. В легких случаях заболевания может быть достаточной доза флувастатина 20 мг (1 капсула Лескола 20 мг). Начальные дозы должны быть подобраны индивидуально в соответствии с базовым уровнем Хс-ЛПНП и целями лечения.; Применение флувастатина одновременно с никотиновой кислотой, колестирамином или фибратами у детей и подростков не изучалось.; Больные с нарушением функции почек; Поскольку флувастатин выводится в основном печенью и лишь менее 6% поступившей в организм дозы экскретируется с мочой, у больных с нарушениями функции почек любой степени тяжести нет необходимости проводить коррекцию дозы препарата.; Больные с нарушением функции печени; Противопоказано применение Лескола Форте при активном заболевании печени или стойком повышении концентрации сывороточных трансаминаз неясной этиологии.; Больные пожилого возраста; Эффективность и хорошая переносимость флувастатина была продемонстрирована для пациентов как старше 65 лет, так и моложе этого возраста. В возрастной группе старше 65 лет ответная реакция на лечение была более выраженной, при этом каких-либо данных, свидетельствующих о худшей переносимости, получено не было. Таким образом, нет необходимости изменения дозы Лескола Форте с учетом возраста."}}]},{"id":5,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Приведенные ниже нежелательные явления перечислены по частоте, начиная с самых частых. Частоту встречаемости нежелательных реакций оценивали следующим образом: возникающие \"очень часто\" - ≥1/10, \"часто\" - ≥1/100 ≤1/10, \"иногда\" - ≥1/1000 ≤1/100, \"редко\" - ≥1/10 000 ≤1/1000, \"очень редко\" - ≤1/10000, включая отдельные сообщения. 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