Выраженные нарушения функции почек, нарушение слуха, полиневрит, угнетение гемопоэза, беременность, повышенная чувствительность к цисплатину.
Инструкция
Состав
1 мл цисплатин 1 мг. Вспомогательные вещества: натрия гидроксид - около 13.7 мг, вода д/и - до 1 мл. * в случае образования осадка под воздействием низких температур раствор перед использованием следует нагреть до 60°С, энергично встряхивая, и затем охладить до комнатной температуры. Осадок должен раствориться. 5 мл - флаконы (1) - пачки картонные.
Фармакологические свойства
Противоопухолевое средство, содержит платину. Механизм действия подобен действию алкилирующих препаратов и заключается в нарушении функции нитей ДНК и образовании сшивок между ними.
Показания к применению
Герминогенная опухоль яичка или яичников, рак яичников, рак тела матки, саркома матки, рак шейки матки и фаллопиевых труб, рак яичников, рак почечной лоханки и мочеточников, рак мочевого пузыря и уретры, рак простаты и полового члена, остеогенная саркома, саркома Юинга, нейробластома, ретинобластома, саркома мягких тканей, лимфома, хорионкарцинома матки, медуллобластома, рак кожи, меланома, опухоль головы и шеи, рак пищевода, рак легкого, рак желудка, рак толстой кишки, злокачественная тимома, мезотелиома.
Противопоказания
Выраженные нарушения функции почек, нарушение слуха, полиневрит, угнетение гемопоэза, беременность, повышенная чувствительность к цисплатину.
Применение при беременности и в период грудного вскармливания
Цисплатин противопоказан при беременности. При необходимости применения в период лактации следует решить вопрос о прекращении грудного вскармливания. Женщины детородного возраста должны применять надежные методы контрацепции во время терапии цисплатином. В экспериментальных исследованиях установлено тератогенное и эмбриотоксическое действие цисплатина.
Способ применения и дозы
Устанавливают индивидуально, в зависимости от показаний и стадии заболевания, состояния системы кроветворения, схемы противоопухолевой терапии.
Побочное действие
Со стороны пищеварительной системы: тошнота, рвота, стоматит, анорексия. Со стороны системы кроветворения: лейкопения, анемия, тромбоцитопения. Со стороны ЦНС: судороги, периферическая невропатия, неврит зрительного нерва, нарушения цветовосприятия, ототоксичность. Со стороны обмена веществ: гиперурикемия, гипокальциемия, гипомагниемия, синдром неадекватной секреции АДГ. Со стороны репродуктивной системы: аменорея, азооспермия. Со стороны сердечно-сосудистой системы: тахикардия, артериальная гипотензия. Аллергические реакции: кожная сыпь, ангионевротический отек, осиплость голоса. Прочие: нефротоксическое действие.
Особые указания
Со стороны пищеварительной системы: тошнота, рвота, стоматит, анорексия. Со стороны системы кроветворения: лейкопения, анемия, тромбоцитопения. Со стороны ЦНС: судороги, периферическая невропатия, неврит зрительного нерва, нарушения цветовосприятия, ототоксичность. Со стороны обмена веществ: гиперурикемия, гипокальциемия, гипомагниемия, синдром неадекватной секреции АДГ. Со стороны репродуктивной системы: аменорея, азооспермия. Со стороны сердечно-сосудистой системы: тахикардия, артериальная гипотензия. Аллергические реакции: кожная сыпь, ангионевротический отек, осиплость голоса. Прочие: нефротоксическое действие.
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