Лонгидаза Свечи, коробка, 10 шт, 3000 МЕ, вагинальные и ректальные

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Биохимическими, иммунологическими,\nгистологическими и электронно-микроскопическими исследованиями доказано, что препарат\nЛонгидаза не повреждает нормальную соединительную ткань, а вызывает\nдеструкцию измененной по составу и структуре соединительной ткани в области\nфиброза."}},{"type":"paragraph","data":{"text":"Препарат Лонгидаза не обладает\nмутагенным, эмбриотоксическим, тератогенным и канцерогенным действием."}},{"type":"paragraph","data":{"text":"Препарат Лонгидаза\u003csup\u003e \u003c/sup\u003eхорошо\nпереносится пациентами, не отмечено местных и общих аллергических реакций."}},{"type":"paragraph","data":{"text":"Применение препарата Лонгидаза в терапевтических дозах во время или после оперативного лечения не вызывает\nухудшение течения послеоперационного периода или прогрессирования инфекционного\nпроцесса; не замедляет восстановление костной ткани. "}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Экспериментальное изучение фармакокинетики позволило\nустановить, что при ректальном введении препарат Лонгидаза характеризуется высокой скоростью распределения в организме, хорошо всасывается\nв системный кровоток и достигает максимальной концентрации в крови через 1 час.\nПериод полураспределения - около 0,5 часа, период полуэлиминации от 42 до 84\nчасов. Выводится преимущественно почками. "}},{"type":"paragraph","data":{"text":"Препарат проникает во все органы и\nткани, в том числе проходит через гематоэнцефалический и гематоофтальмический\nбарьеры. Установлено отсутствие тканевой кумуляции."}},{"type":"paragraph","data":{"text":"Биодоступность препарата\nЛонгидаза при ректальном введении высокая: около 90 %."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Взрослым и подросткам старше 12 лет в\nвиде монотерапии и в составе комплексной терапии заболеваний, сопровождающихся\nгиперплазией соединительной ткани, в том числе и на фоне воспалительного\nпроцесса:"}},{"type":"paragraph","data":{"text":"·       \nв урологии: хронический простатит (в том\nчисле для профилактики рецидивов), интерстициальный цистит, стриктуры уретры и\nмочеточников, болезнь Пейрони, начальная стадия доброкачественной гиперплазии\nпредстательной железы, профилактика образования рубцов и стриктур после\nоперативных вмешательств на уретре, мочевом пузыре, мочеточниках;"}},{"type":"paragraph","data":{"text":"·       \nв гинекологии:\nспаечный процесс (профилактика и лечение) в малом тазу при хронических\nвоспалительных заболеваниях внутренних половых органов, после гинекологических\nманипуляций, в том числе искусственных абортов, перенесенных ранее оперативных\nвмешательств на органах малого таза; внутриматочные синехии,\nтрубно-перитонеальное бесплодие, хронический эндомиометрит;"}},{"type":"paragraph","data":{"text":"·       \nв дерматовенерологии:\nограниченная склеродермия, профилактика фиброзных осложнений инфекций,\nпередающихся половым путем;"}},{"type":"paragraph","data":{"text":"·       \nв хирургии:\nпрофилактика и лечение спаечного процесса после оперативных вмешательств на\nорганах брюшной полости; длительно незаживающие раны;"}},{"type":"paragraph","data":{"text":"·       \nв пульмонологии и фтизиатрии:\nпневмофиброз, сидероз, туберкулез (кавернозно-фиброзный, инфильтративный,\nтуберкулема), интерстициальная пневмония, фиброзирующий альвеолит, плеврит;"}},{"type":"paragraph","data":{"text":"·       \nдля увеличения биодоступности\nантибактериальной терапии в урологии, гинекологии, дерматовенерологии,\nхирургии, пульмонологии и др. "}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"·          \nгиперчувствительность\nк действующему веществу или любому другому компоненту препарата;"}},{"type":"paragraph","data":{"text":"·          \nлегочное\nкровотечение и кровохарканье;"}},{"type":"paragraph","data":{"text":"·          \nсвежее\nкровоизлияние в стекловидное тело;"}},{"type":"paragraph","data":{"text":"·          \nострая\nпочечная недостаточность;"}},{"type":"paragraph","data":{"text":"·          \nдетский возраст до 12 лет (результаты клинических\nисследований отсутствуют);"}},{"type":"paragraph","data":{"text":"·          \nзлокачественные новообразования;"}},{"type":"paragraph","data":{"text":"·          \nбеременность, период грудного вскармливания."}}]},{"id":14,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью применять\nне чаще 1 раза в неделю у больных с хронической почечной недостаточностью,\nлегочными кровотечениями в анамнезе."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение при\nбеременности противопоказано (нет данных о безопасности препарата при\nбеременности). "}},{"type":"paragraph","data":{"text":"\u003ca\u003eСогласно\nимеющимся данным доклинических исследований введение препарата в дозах, в 10\nраз превышающих эквитерапевтические, отрицательного воздействия на лактацию и\nразвитие потомства, не оказывает. \u003c/a\u003eРезультаты экспериментальных исследований не дают прямых\nдоказательств отсутствия выделения препарата Лонгидаза c молоком у животных. При необходимости\nприменения препарата в период лактации, грудное вскармливание следует\nпрекратить."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат\nЛонгидаза суппозитории 3000 МЕ рекомендуется для \u003cb\u003eректального\u003c/b\u003e или \u003cb\u003eвагинального\u003c/b\u003e применения один раз в сутки на ночь курсом от 10 до 20\nвведений. "}},{"type":"paragraph","data":{"text":"\u003cb\u003eПодросткам от 12 до 18 лет суппозитории вводятся только\nректально.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003eВзрослым и подросткам старше 12 лет\u003c/b\u003e ректально: по 1 суппозиторию 1 раз в\nсутки после очищения кишечника. "}},{"type":"paragraph","data":{"text":"\u003cb\u003eВзрослым\u003c/b\u003e вагинально:\u003cb\u003e \u003c/b\u003eпо 1 суппозиторию\n1 раз в сутки (на ночь) суппозиторий вводится во влагалище в положении лежа."}},{"type":"paragraph","data":{"text":"Схема\nвведения корректируется в зависимости от тяжести, стадии и длительности\nзаболевания: препарат Лонгидаза назначается через день или с\nперерывами в 2-3 дня. "}},{"type":"paragraph","data":{"text":"Рекомендуемые схемы и дозы:"}},{"type":"paragraph","data":{"text":"·           \nв урологии: по 1 суппозиторию через день 10\nвведений, далее через 2-3 дня "}},{"type":"paragraph","data":{"text":"·           \nв\nгинекологии: ректально или вагинально по 1 суппозиторию через 2 дня "}},{"type":"paragraph","data":{"text":"\n10 введений, далее при необходимости назначается поддерживающая терапия."}},{"type":"paragraph","data":{"text":"·           \nв\nдерматовенерологии: по 1 суппозиторию через 1-2 дня 10-15 введений. "}},{"type":"paragraph","data":{"text":"·           \nв\nхирургии: по 1 суппозиторию через 2-3 дня 10 введений."}},{"type":"paragraph","data":{"text":"·           \nв\nпульмонологии и фтизиатрии: по 1 суппозиторию через 2-4 дня 10-20 введений. "}},{"type":"paragraph","data":{"text":"При необходимости рекомендуется\nповторный курс препарата Лонгидаза не ранее, чем через три месяца\nили длительная поддерживающая терапия по 1 суппозиторию 1 раз в 5-7 дней в\nтечение 3-4 мес."}},{"type":"paragraph","data":{"text":"Если в период лечения улучшения не\nнаступает или симптомы усугубляются, или появляются новые симптомы, необходимо\nпроконсультироваться с врачом. Применяйте препарат только согласно тем показаниям,\nтому способу применения и в тех дозах, которые указаны в инструкции."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота\nнежелательных реакций представлена по следующей классификации: "}},{"type":"paragraph","data":{"text":"\nочень частые ≥ 10 %; частые ≥ 1 % и < 10%; нечастые ≥ 0,1 % и < 1 %;\nредкие ≥ 0,01 % "}},{"type":"paragraph","data":{"text":"\nи < 0,1 %; очень редкие < 0,001 %.  "}},{"type":"paragraph","data":{"text":"Очень\nредко: местные реакции в виде покраснения, отека, зуда перианальной зоны,\nвагинального зуда в связи с индивидуальной чувствительностью к компонентам\nпрепарата."}},{"type":"paragraph","data":{"text":"Если у\nВас отмечаются побочные эффекты, указанные в инструкции или они усугубляются,\nили Вы заметили любые другие побочные эффекты, не указанные в инструкции,\nсообщите об этом врачу."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы передозировки могут\nпроявляться ознобом, повышением температуры, головокружением, гипотензией. Лечение:\nотмена препарата, проведение симптоматической терапии."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Препарат\u003cb\u003e \u003c/b\u003eЛонгидаза можно комбинировать с антибиотиками,\nпротивовирусными, противогрибковыми препаратами, бронхолитиками.  При назначении в комбинации с другими\nлекарственными средствами (антибиотики, местные анестетики, диуретики) следует\nучитывать возможность увеличения биодоступности и усиления их действия.  При совместном применении с большими дозами\nсалицилатов, кортизона, адренокортикотропного гормона (АКТГ), эстрогенов или\nантигистаминных препаратов может быть снижена ферментативная активность\nпрепарата Лонгидаза. "}},{"type":"paragraph","data":{"text":"Не\nследует применять препарат Лонгидаза одновременно с фуросемидом,\nбензодиазепинами, фенитоином и адреналином."}},{"type":"paragraph","data":{"text":"Если Вы\nприменяете вышеперечисленные или другие лекарственные препараты (в том числе\nбезрецептурные) перед применением препарата Лонгидаза проконсультируйтесь с\nврачом."}}]},{"id":9,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При приеме препарата неукоснительно\nследуйте данным в инструкции указаниям. "}},{"type":"paragraph","data":{"text":"Если у вас возникнут вопросы, то\nобратитесь за разъяснением к вашему врачу."}},{"type":"paragraph","data":{"text":"При развитии нежелательных реакций следует\nпрекратить применение препарата Лонгидаза\u003csup\u003e \u003c/sup\u003eи обратиться к лечащему\nврачу. "}},{"type":"paragraph","data":{"text":"При применении на фоне обострения\nочагов инфекции для предупреждения распространения инфекции необходимо\nназначать под прикрытием антимикробных средств."}},{"type":"paragraph","data":{"text":"Так как возможно непрогнозируемое\nускорение адсорбции и увеличение системного действия, необходимо соблюдать\nосторожность и учитывать фармакокинетические характеристики лекарственных\nсредств, назначаемых в комбинации с препаратом Лонгидаза."}},{"type":"paragraph","data":{"text":"Не использовать препарат\nпри наличии визуальных признаков его непригодности (дефект упаковки, изменение\nцвета суппозитория). "}},{"type":"paragraph","data":{"text":"В случае пропуска\nвведения очередной дозы препарата далее применять в обычном режиме (не вводить\nудвоенную дозу). "}},{"type":"paragraph","data":{"text":"При\nнеобходимости прекращения приема препарата Лонгидаза отмену можно\nосуществить сразу, без постепенного уменьшения дозы."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Применение препарата Лонгидаза не влияет на\nспособность управления транспортными средствами, обслуживание механизмов и\nдругие виды работ, требующих повышенной концентрации внимания и быстроты\nпсихомоторных реакций."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Суппозитории\nвагинальные и ректальные 3000 МЕ."}},{"type":"paragraph","data":{"text":"5 суппозиториев в контурной ячейковой упаковке из пленки\nполивинилхлоридной. Одна, две или четыре контурные ячейковые упаковки в\nпачке из картона вместе с инструкцией по применению."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 15 °С. Не\nзамораживать. Хранить в недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не\nприменять после истечения срока годности."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без\nрецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Производство /\nФасовка (первичная упаковка): "}},{"type":"paragraph","data":{"text":"Россия, 115598,\nг. Москва, ул. Загорьевская, д. 10, корп. 4, "}},{"type":"paragraph","data":{"text":"тел./факс: +7 (495)\n329-17-18."}},{"type":"paragraph","data":{"text":"Россия, 142143,\nМосковская обл., г. Подольск, с. Покров, ул. Сосновая, д. 1, "}},{"type":"paragraph","data":{"text":"тел./факс: +7\n(495) 926-21-07."}},{"type":"paragraph","data":{"text":"Вторичная\n(потребительская) упаковка / Выпускающий контроль качества: "}},{"type":"paragraph","data":{"text":"Россия, 142143,\nМосковская обл., г. Подольск, с. Покров, ул. Сосновая, д. 1, "}},{"type":"paragraph","data":{"text":"тел./факс: +7 (495)\n926-21-07."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Владелец\nрегистрационного удостоверения и производитель: "}},{"type":"paragraph","data":{"text":"ООО «НПО\nПетровакс Фарм»"}},{"type":"paragraph","data":{"text":"Юридический\nадрес / Адрес для предъявления претензий потребителей: "}},{"type":"paragraph","data":{"text":"Россия, 142143,\nМосковская обл., г. Подольск, с. Покров, ул. Сосновая, д.1,"}},{"type":"paragraph","data":{"text":"тел./факс: +7 (495)\n926-21-07, e-mail: info@petrovax.ru;"}},{"type":"paragraph","data":{"text":"для\nпредъявления претензий:         "}},{"type":"paragraph","data":{"text":"тел.: +7 (495)\n730-75-45, 8 (800) 234-44-80, e-mail: adr@petrovax.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаПрепарат Лонгидаза обладает гиалуронидазной (ферментативной) активностью пролонгированного действия, хелатирующими, антиоксидантными, иммуномодулирующими и умеренно выраженными противовоспалительными свойствами. Пролонгирование действия фермента достигается ковалентным связыванием фермента с физиологически активным полимерным носителем (азоксимер). Препарат Лонгидаза проявляет противофиброзные свойства, ослабляет течение острой фазы воспаления, регулирует (повышает или снижает в зависимости от исходного уровня) синтез медиаторов воспаления (интерлейкина-1 и фактора некроза опухоли - альфа), повышает гуморальный иммунный ответ и резистентность организма к инфекции. Выраженные противофиброзные свойства препарата Лонгидаза обеспечиваются конъюгацией гиалуронидазы с носителем, что значительно увеличивает устойчивость фермента к денатурирующим воздействиям и действию ингибиторов: ферментативная активность препарата Лонгидаза сохраняется при нагревании до 37 °С в течение 20 суток, в то время как нативная гиалуронидаза в этих же условиях утрачивает свою активность в течение суток. В препарате Лонгидаза обеспечивается одновременное локальное присутствие фермента гиалуронидазы и носителя, способного связывать освобождающиеся при гидролизе компонентов матрикса ингибиторы фермента и стимуляторы синтеза коллагена (ионы железа, меди, гепарин и др.). Благодаря указанным свойствам препарат Лонгидаза обладает не только способностью деполимеризовать матрикс соединительной ткани в фиброзно-гранулематозных образованиях, но и подавлять обратную регуляторную реакцию, направленную на синтез компонентов соединительной ткани. Специфическим субстратом тестикулярной гиалуронидазы являются гликозаминогликаны (гиалуроновая кислота, хондроитин, хондроитин-4-сульфат, хондроитин-6-сульфат), составляющие основу матрикса соединительной ткани. В результате деполимеризации (разрыва связи между С1ацетилглюкозамина и С4глюкуроновой или индуроновой кислот) гликозаминогликаны изменяют свои основные свойства: снижается вязкость, уменьшается способность связывать воду, ионы металлов, временно увеличивается проницаемость тканевых барьеров, облегчается движение жидкости в межклеточном пространстве, увеличиваетсяэластичностьсоединительной ткани, что проявляется в уменьшении отечности ткани, уплощении рубцов, увеличении объема движения суставов, уменьшении контрактур и предупреждении их формирования, уменьшении спаечного процесса. Биохимическими, иммунологическими, гистологическими и электронно-микроскопическими исследованиями доказано, что препарат Лонгидаза не повреждает нормальную соединительную ткань, а вызывает деструкцию измененной по составу и структуре соединительной ткани в области фиброза. Препарат Лонгидаза не обладает мутагенным, эмбриотоксическим, тератогенным и канцерогенным действием. Препарат Лонгидазахорошо переносится пациентами, не отмечено местных и общих аллергических реакций. Применение препарата Лонгидаза в терапевтических дозах во время или после оперативного лечения не вызывает ухудшение течения послеоперационного периода или прогрессирования инфекционного процесса; не замедляет восстановление костной ткани.ФармакокинетикаЭкспериментальное изучение фармакокинетики позволило установить, что при ректальном введении препарат Лонгидаза характеризуется высокой скоростью распределения в организме, хорошо всасывается в системный кровоток и достигает максимальной концентрации в крови через 1 час. Период полураспределения - около 0,5 часа, период полуэлиминации от 42 до 84 часов. Выводится преимущественно почками. Препарат проникает во все органы и ткани, в том числе проходит через гематоэнцефалический и гематоофтальмический барьеры. Установлено отсутствие тканевой кумуляции. 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