Белые, или серовато-белые таблетки в виде диска с фаской, с гравировкой “SUPRASTIN” на одной стороне таблетки и риской на другой стороне, без или почти без запаха.
Фармакотерапевтическая группа
противоаллергическое средство - Н1 -гистаминовых рецепторов блокатор.
Фармакологические свойства
Фармакодинамика
Хлоропирамин - хлорированный аналог трипеленамина (пирибензамина) - это антигистаминный препарат первого поколения, принадлежащий к группе этилендиаминовых антигистаминных препаратов.
Блокатор Н1-гистаминовых рецепторов, оказывает антигистаминное и м-холиноблокирующее действие. Этот препарат также действует на гладкие мышцы, на проницаемость капилляров и на центральную нервную систему (ЦНС).
При приеме внутрь эффект проявляется уже через 15-30 минут, максимальный эффект развивается в течение 1 часа и продолжается примерно 3-6 часов.
Фармакокинетика
При пероральном приеме практически полностью абсорбируется из желудочно-кишечного тракта (ЖКТ). Терапевтический эффект хлоропирам ина развивается в течение 15-30 минут после приема внутрь, достигает максимума в течение первого часа после приема и длится минимум 3-6 часов.
Всасывание
При пероральном приеме практически полностью абсорбируется из желудочно-кишечного тракта (ЖКТ). Терапевтический эффект хлоропирам ина развивается в течение 15-30 минут после приема внутрь, достигает максимума в течение первого часа после приема и длится минимум 3-6 часов.
Распределение
Хорошо распределяется в организме, включая ЦНС.
Метаболизм
Интенсивно метаболизируется в печени.
Выведение
Выводится в основном почками в виде метаболитов.
Особые популяции пациентов
Дети и подростки
У детей выведение препарата происходит быстрее, чем у взрослых пациентов.
Пациенты с нарушением функции печени
У пациентов с нарушением функции печени метаболизм хлоропирамина понижается, поэтому доза Супрастина может быть уменьшена.
Пациенты с нарушением функции почек
У пациентов с нарушением функции почек понижается выведение активного вещества, поэтому доза Супрастина может быть уменьшена.
Показания к применению
Крапивница
Сывороточная болезнь
Сезонный и круглогодичный аллергический ринит
Конъюнктивит
Контактный дерматит
Кожный зуд
Острая и хроническая экзема
Атопический дерматит
Пищевая и лекарственная аллергия
Аллергические реакции на укусы насекомых
Ангионевротический отек (отек Квинке) - для раствора
Ангионевротический отек (отек Квинке) - в качестве вспомогательного средства - для таблеток
Противопоказания
Острый приступ бронхиальной астмы
Беременность
Лактация (грудное вскармливание)
Детский возраст до 3 лет (для таблеток)
Дефицит лактазы, неперносимость лактозы, синдром мальабсорбции глюкозы-галактозы (для таблеток, т.к. 1 таб. содержит 116 мг лактозы моногидрата)
Новорожденные дети (доношенные и недоношенные)
Повышенная чувствительность к компонентам препарата. С осторожностью следует применять препарат при закрытоугольной глаукоме, у пациентов с задержкой мочи и гиперплазией предстательной железы, при нарушениях функции печени и/или почек, сердечно-сосудистых заболеваниях, у пациентов пожилого возраста
С осторожностью
Пациентам пожилого возраста, а также при нарушении функции печени и/или почек, сердечно-сосудистой системы, при закрытоугольной глаукоме, задержке мочи, гиперплазии предстательной железы.
Применение при беременности и в период грудного вскармливания
Беременность
Не было проведено адекватных контролируемых клинических исследований применения антигистаминных препаратов у беременных женщин. Однако у новорожденных, матери которых принимали антигистаминные препараты на последних месяцах беременности, были описаны случаи развития ретролентальной фиброплазии. В соответствии с этим применение препарата Супрастин во время беременности противопоказано.
Грудное вскармливание
Применение препарата Супрастин противопоказано в период грудного вскармливания.
При необходимости применения препарата в период лактации следует прекратить грудное вскармливание.
Способ применения и дозы
Таблетки принимают внутрь во время еды, не разжевывая и запивая достаточным количеством воды.
Взрослым:
Назначают по 1 таблетке 3-4 раза в день (75-100 мг в сутки).
Детям:
В возрасте от 3-х до 6-и лет: по 1/2 таблетки (12,5 мг) 2 раза в день; суточная доза - 25 мг.
В возрасте от 6-и до 14-и лет: по 1/2 таблетки (12,5 мг) 2-3 раза в день; суточная доза - 25-37,5 мг.
В возрасте от 14-и до 18 лет: по 1 таблетке (25 мг) 3-4 раза в день; суточная доза -75-100 мг.
Дозу детям можно постепенно повышать при отсутствии побочных эффектов у пациента, но максимальная доза никогда не должна превышать 2 мг/кг массы тела.
Продолжительность курса лечения зависит от характера, симптомов заболевания, степени их проявления, длительности и течения заболевания.
Особые группы пациентов
Пожилые пациенты и пациенты с выраженным дефицитом массы тела
Применение препарата Супрастин® требует особой осторожности, так как у этих пациентов антигистаминные препараты чаще вызывают побочные эффекты (головокружение, сонливость, падение артериального давления (АД)).
Пациенты с нарушением функции печени
Может потребоваться снижение дозы в связи со снижением метаболизма активного компонента препарата при заболеваниях печени.
Пациенты с нарушением функции почек
Может потребоваться изменение режима приема препарата и снижение дозы в связи с тем, что активный компонент в основном выделяется почками.
Побочное действие
Побочные эффекты возникают, как правило, крайне редко, носят временный характер и проходят после отмены препарата. Со стороны системы кроветворения: очень редко - лейкопения, агранулоцитоз, гемолитическая анемия и другие изменения клеточного состава крови. Со стороны ЦНС: сонливость, утомляемость, головокружение, нервное возбуждение, тремор, головная боль, эйфория, судороги, энцефалопатия. Со стороны органа зрения: нечеткость зрительного восприятия, глаукома, повышение внутриглазного давления. Со стороны сердечно-сосудистой системы: снижение АД, тахикардия, аритмия (не всегда была установлена прямая связь этих побочных эффектов с приемом препарата). Со стороны пищеварительной системы: дискомфорт в животе, сухость во рту, тошнота, рвота, диарея, запор, потеря или повышение аппетита, боль в эпигастрии. Со стороны мочевыделительной системы: затрудненное мочеиспускание, задержка мочи. Со стороны костно-мышечной системы: мышечная слабость. Прочие: фотосенсибилизация, аллергические реакции. При возникновении любого из перечисленных выше эффектов пациенту следует прекратить прием препарата и немедленно обратится к врачу.
Передозировка
Симптомы: галлюцинации, беспокойство, атаксия, нарушение координации движений, атетоз, судороги; у детей раннего возраста - возбуждение, тревожность, сухость во рту, фиксированные расширенные зрачки, покраснение лица, синусовая тахикардия, задержка мочи, лихорадка, кома; у взрослых - лихорадка и покраснение лица наблюдаются непостоянно, после периода возбуждения следуют судороги и послесудорожная депрессия, кома. Лечение: в период до 12 ч после приема препарата - промывание желудка (следует учитывать, что опорожнению желудка препятствует антихолинергический эффект препарата), назначение активированного угля, контроль параметров АД и дыхания, проведение симптоматической терапии, при необходимости - реанимационные мероприятия. Специфический антидот неизвестен.
Взаимодействие с другими лекарственными средствами
Ингибиторы моноаминооксидазы усиливают и пролонгируют антихолинергические эффекты препарата Супрастин.
Следует соблюдать особую осторожность при одновременном применении таблеток Супрастин с барбитуратами, снотворными, анксиолитическими и седативными средствами, транквилизаторами, опиоидными анальгетиками, трициклическими антидепрессантами, атропином, мускаринергическими парасимпатолитиками (Супрастин и любой из этих препаратов могут усиливать эффекты друг друга).
Во время лечения запрещено употребление алкогольных напитков (алкоголь усиливает угнетающий эффект препарата Супрастин на ЦНС).
При сочетании с ототоксическими препаратами Супрастин может маскировать ранние признаки ототоксичности.
Антигистаминные препараты подавляют кожные реакции в ответ на аллергические кожные пробы, таким образом, за несколько дней до проведения кожных проб следует отменить применение препарата Супрастин.
Особые указания
При сочетании с ототоксическими препаратами Супрастин; может маскировать ранние признаки ототоксичности. Заболевания печени и почек могут потребовать изменения (снижения) дозы препарата, в связи с чем пациент должен информировать врача о наличии у него заболевания печени или почек. Прием препарата на ночь может усиливать симптомы рефлюкс-эзофагита. Супрастин; может усилить действие этанола на ЦНС, в связи с чем во время приема препарата Супрастин; следует избегать употребления алкогольных напитков. Длительное применение антигистаминных препаратов может привести к нарушениям со стороны системы кроветворения (лейкопения, агранулоцитоз, тромбоцитопения, гемолитическая анемия). Если во время длительного применения наблюдается необъяснимое повышение температуры тела, ларингит, бледность кожных покровов, желтуха, образование язв во рту, появление гематом, необычные и длительно продолжающиеся кровотечения, необходимо провести клинический анализ крови с определением числа форменных элементов. Если результаты анализа указывают на изменение формулы крови, прием препарата прекращают. Влияние на способность к вождению автотранспорта и управлению механизмамиПрепарат, особенно в начальном периоде лечения, может вызывать сонливость, утомляемость и головокружение. Поэтому в начальном периоде, длительность которого определяется индивидуально, запрещается вождение транспортных средств или выполнение работ, связанных с повышенным риском несчастных случаев. После этого степень ограничения на вождение транспорта и работу с механизмами врач должен определять для каждого пациента индивидуально.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат, особенно в начальном периоде лечения, может вызывать сонливость, утомляемость и головокружение. Поэтому в начальном периоде, длительность которого определяется индивидуально, запрещается вождение транспортных средств или выполнение работ, связанных с повышенным риском несчастных случаев. После этого степень ограничения на вождение транспорта и работу с механизмами врач должен определять для каждого пациента индивидуально.
Форма выпуска
Таблетки по 25 мг.
По 10 таблеток в блистере из ПВХ/ал.фольга. По 2 или 4 блистера в картонной пачке вместе с инструкцией по медицинскому применению.
По 20 таблеток в блистере из ПВХ/ал.фольга. По 1 блистеру в картонной пачке вместе с инструкцией по медицинскому применению.
Условия хранения
Хранить при температуре не выше 25 °C. Хранить в недоступном для детей месте!
Срок годности
5 лет. Не применять после даты, указанной на упаковке.
Условия отпуска
Отпускают без рецепта.
Производитель
ЗАО «Фармацевтический завод ЭГИС», Венгрия
1165, Будапешт, ул. Бекеньфелди 118-120
Организация, принимающая претензии потребителей
ООО «ЭГИС-РУС», Россия
121108, г. Москва, ул. Ивана Франко, д. 8
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Однако у новорожденных, матери которых принимали антигистаминные препараты на последних месяцах беременности, были описаны случаи развития ретролентальной фиброплазии. В соответствии с этим применение препарата Супрастин во время беременности противопоказано."}},{"type":"paragraph","data":{"text":"Грудное вскармливание"}},{"type":"paragraph","data":{"text":"Применение препарата Супрастин противопоказано в период грудного вскармливания."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата в период лактации следует прекратить грудное вскармливание."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки принимают внутрь во время еды, не разжевывая и запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"Взрослым:"}},{"type":"paragraph","data":{"text":"Назначают по 1 таблетке 3-4 раза в день (75-100 мг в сутки)."}},{"type":"paragraph","data":{"text":"Детям:"}},{"type":"paragraph","data":{"text":"В возрасте от 3-х до 6-и лет: по 1/2 таблетки (12,5 мг) 2 раза в день; суточная доза - 25 мг."}},{"type":"paragraph","data":{"text":"В возрасте от 6-и до 14-и лет: по 1/2 таблетки (12,5 мг) 2-3 раза в день; суточная доза - 25-37,5 мг."}},{"type":"paragraph","data":{"text":"В возрасте от 14-и до 18 лет: по 1 таблетке (25 мг) 3-4 раза в день; суточная доза -75-100 мг."}},{"type":"paragraph","data":{"text":"Дозу детям можно постепенно повышать при отсутствии побочных эффектов у пациента, но максимальная доза никогда не должна превышать 2 мг/кг массы тела."}},{"type":"paragraph","data":{"text":"Продолжительность курса лечения зависит от характера, симптомов заболевания, степени их проявления, длительности и течения заболевания."}},{"type":"paragraph","data":{"text":"Особые группы пациентов"}},{"type":"paragraph","data":{"text":"Пожилые пациенты и пациенты с выраженным дефицитом массы тела"}},{"type":"paragraph","data":{"text":"Применение препарата Супрастин® требует особой осторожности, так как у этих пациентов антигистаминные препараты чаще вызывают побочные эффекты (головокружение, сонливость, падение артериального давления (АД))."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции печени"}},{"type":"paragraph","data":{"text":"Может потребоваться снижение дозы в связи со снижением метаболизма активного компонента препарата при заболеваниях печени."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции почек"}},{"type":"paragraph","data":{"text":"Может потребоваться изменение режима приема препарата и снижение дозы в связи с тем, что активный компонент в основном выделяется почками."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Побочные эффекты возникают, как правило, крайне редко, носят временный характер и проходят после отмены препарата. Со стороны системы кроветворения: очень редко - лейкопения, агранулоцитоз, гемолитическая анемия и другие изменения клеточного состава крови. Со стороны ЦНС: сонливость, утомляемость, головокружение, нервное возбуждение, тремор, головная боль, эйфория, судороги, энцефалопатия. Со стороны органа зрения: нечеткость зрительного восприятия, глаукома, повышение внутриглазного давления. Со стороны сердечно-сосудистой системы: снижение АД, тахикардия, аритмия (не всегда была установлена прямая связь этих побочных эффектов с приемом препарата). Со стороны пищеварительной системы: дискомфорт в животе, сухость во рту, тошнота, рвота, диарея, запор, потеря или повышение аппетита, боль в эпигастрии. Со стороны мочевыделительной системы: затрудненное мочеиспускание, задержка мочи. Со стороны костно-мышечной системы: мышечная слабость. Прочие: фотосенсибилизация, аллергические реакции. При возникновении любого из перечисленных выше эффектов пациенту следует прекратить прием препарата и немедленно обратится к врачу."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: галлюцинации, беспокойство, атаксия, нарушение координации движений, атетоз, судороги; у детей раннего возраста - возбуждение, тревожность, сухость во рту, фиксированные расширенные зрачки, покраснение лица, синусовая тахикардия, задержка мочи, лихорадка, кома; у взрослых - лихорадка и покраснение лица наблюдаются непостоянно, после периода возбуждения следуют судороги и послесудорожная депрессия, кома. Лечение: в период до 12 ч после приема препарата - промывание желудка (следует учитывать, что опорожнению желудка препятствует антихолинергический эффект препарата), назначение активированного угля, контроль параметров АД и дыхания, проведение симптоматической терапии, при необходимости - реанимационные мероприятия. Специфический антидот неизвестен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Ингибиторы моноаминооксидазы усиливают и пролонгируют антихолинергические эффекты препарата Супрастин."}},{"type":"paragraph","data":{"text":"Следует соблюдать особую осторожность при одновременном применении таблеток Супрастин с барбитуратами, снотворными, анксиолитическими и седативными средствами, транквилизаторами, опиоидными анальгетиками, трициклическими антидепрессантами, атропином, мускаринергическими парасимпатолитиками (Супрастин и любой из этих препаратов могут усиливать эффекты друг друга)."}},{"type":"paragraph","data":{"text":"Во время лечения запрещено употребление алкогольных напитков (алкоголь усиливает угнетающий эффект препарата Супрастин на ЦНС)."}},{"type":"paragraph","data":{"text":"При сочетании с ототоксическими препаратами Супрастин может маскировать ранние признаки ототоксичности."}},{"type":"paragraph","data":{"text":"Антигистаминные препараты подавляют кожные реакции в ответ на аллергические кожные пробы, таким образом, за несколько дней до проведения кожных проб следует отменить применение препарата Супрастин."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При сочетании с ототоксическими препаратами Супрастин; может маскировать ранние признаки ототоксичности. Заболевания печени и почек могут потребовать изменения (снижения) дозы препарата, в связи с чем пациент должен информировать врача о наличии у него заболевания печени или почек. Прием препарата на ночь может усиливать симптомы рефлюкс-эзофагита. Супрастин; может усилить действие этанола на ЦНС, в связи с чем во время приема препарата Супрастин; следует избегать употребления алкогольных напитков. Длительное применение антигистаминных препаратов может привести к нарушениям со стороны системы кроветворения (лейкопения, агранулоцитоз, тромбоцитопения, гемолитическая анемия). Если во время длительного применения наблюдается необъяснимое повышение температуры тела, ларингит, бледность кожных покровов, желтуха, образование язв во рту, появление гематом, необычные и длительно продолжающиеся кровотечения, необходимо провести клинический анализ крови с определением числа форменных элементов. Если результаты анализа указывают на изменение формулы крови, прием препарата прекращают. Влияние на способность к вождению автотранспорта и управлению механизмамиПрепарат, особенно в начальном периоде лечения, может вызывать сонливость, утомляемость и головокружение. Поэтому в начальном периоде, длительность которого определяется индивидуально, запрещается вождение транспортных средств или выполнение работ, связанных с повышенным риском несчастных случаев. После этого степень ограничения на вождение транспорта и работу с механизмами врач должен определять для каждого пациента индивидуально."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат, особенно в начальном периоде лечения, может вызывать сонливость, утомляемость и головокружение. Поэтому в начальном периоде, длительность которого определяется индивидуально, запрещается вождение транспортных средств или выполнение работ, связанных с повышенным риском несчастных случаев. После этого степень ограничения на вождение транспорта и работу с механизмами врач должен определять для каждого пациента индивидуально."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nТаблетки по 25 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток в блистере из ПВХ/ал.фольга. По 2 или 4 блистера в картонной пачке вместе с инструкцией по медицинскому применению."}},{"type":"paragraph","data":{"text":"По 20 таблеток в блистере из ПВХ/ал.фольга. По 1 блистеру в картонной пачке вместе с инструкцией по медицинскому применению.\n\n"}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °C. Хранить в недоступном для детей месте!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не применять после даты, указанной на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nЗАО «Фармацевтический завод ЭГИС», Венгрия"}},{"type":"paragraph","data":{"text":"1165, Будапешт, ул. Бекеньфелди 118-120\n\n"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nООО «ЭГИС-РУС», Россия"}},{"type":"paragraph","data":{"text":"121108, г. Москва, ул. Ивана Франко, д. 8\n\n"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Фармакодинамика Хлоропирамин - хлорированный аналог трипеленамина (пирибензамина) - это антигистаминный препарат первого поколения, принадлежащий к группе этилендиаминовых антигистаминных препаратов. Блокатор Н1-гистаминовых рецепторов, оказывает антигистаминное и м-холиноблокирующее действие. Этот препарат также действует на гладкие мышцы, на проницаемость капилляров и на центральную нервную систему (ЦНС). При приеме внутрь эффект проявляется уже через 15-30 минут, максимальный эффект развивается в течение 1 часа и продолжается примерно 3-6 часов. Фармакокинетика При пероральном приеме практически полностью абсорбируется из желудочно-кишечного тракта (ЖКТ). Терапевтический эффект хлоропирам ина развивается в течение 15-30 минут после приема внутрь, достигает максимума в течение первого часа после приема и длится минимум 3-6 часов. Всасывание При пероральном приеме практически полностью абсорбируется из желудочно-кишечного тракта (ЖКТ). Терапевтический эффект хлоропирам ина развивается в течение 15-30 минут после приема внутрь, достигает максимума в течение первого часа после приема и длится минимум 3-6 часов. Распределение Хорошо распределяется в организме, включая ЦНС. Метаболизм Интенсивно метаболизируется в печени. Выведение Выводится в основном почками в виде метаболитов. Особые популяции пациентов Дети и подростки У детей выведение препарата происходит быстрее, чем у взрослых пациентов. Пациенты с нарушением функции печени У пациентов с нарушением функции печени метаболизм хлоропирамина понижается, поэтому доза Супрастина может быть уменьшена. Пациенты с нарушением функции почек У пациентов с нарушением функции почек понижается выведение активного вещества, поэтому доза Супрастина может быть уменьшена.","substance":[{"id":163,"title":"Хлоропирамин","title_latin":"Chloropyraminum","slug":"hloropiramin_163"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":{"count":18,"url":"/review/788-suprastin/"},"image_alt":"Супрастин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/3724/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/3724/share_default/"}},"diseases":[{"id":"615","title":"Острый атопический (аллергический) конъюнктивит","slug":"615-ostryy_atopicheskiy_allergicheskiy_konyunktivit"},{"id":"811","title":"Вазомоторный и аллергический ринит","slug":"811-vazomotornyy_i_allergicheskiy_rinit"},{"id":"813","title":"Аллергический ринит, вызванный пыльцой 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