Хемомицин Порошок, флакон, 1 шт, 20 мл, 200/5 мг/мл, для приготовления суспензии

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значимой"}},{"type":"paragraph","data":{"text":"брадикардией, аритмией сердца или тяжелой сердечной недостаточностью;"}},{"type":"paragraph","data":{"text":"одновременное применение дигоксина, варфарина, циклоспорина.\n"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"При беременности и в период грудного вскармливания применяют только в случае, если"}},{"type":"paragraph","data":{"text":"предполагаемая польза для матери превышает потенциальный риск для плода и ребенка."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата в период грудного вскармливания"}},{"type":"paragraph","data":{"text":"рекомендуется приостановить грудное вскармливание.\n"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eСуспензия 200 мг/5 мл и 100 мг/5 мл\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"У \u003cb\u003eдетей старше 12 мес\u003c/b\u003e применяют суспензию 200 мг/5 мл, у \u003cb\u003eдетей старше 6 мес\u003c/b\u003e - суспензию 100 мг/5 мл."}},{"type":"paragraph","data":{"text":"\u003cb\u003eДетям \u003c/b\u003eпри \u003ci\u003eинфекциях верхних и нижних отделов дыхательных путей, инфекциях кожи и мягких тканей\u003c/i\u003e (за исключением хронической мигрирующей эритемы) Хемомицин в форме суспензии назначают из расчета 10 мг/кг массы тела 1 раз/сут в течение 3 дней (курсовая доза - 30 мг/кг)."}},{"type":"paragraph","data":{"text":"\u003cb\u003eВзрослым\u003c/b\u003e при \u003ci\u003eинфекциях верхних и нижних отделов дыхательных путей\u003c/i\u003e назначают по 500 мг 1 раз/сут в течение 3 дней; курсовая доза - 1.5 г."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eинфекциях урогенитального тракта\u003c/i\u003e препарат назначают \u003cb\u003eвзрослым\u003c/b\u003e в дозе 1 г однократно; \u003cb\u003eдетям до 8 лет при массе тела более 45 кг\u003c/b\u003e - 10 мг/кг однократно."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eхронической мигрирующей эритеме\u003c/i\u003e назначают 1 раз/сут в течение 5 дней: \u003cb\u003eвзрослым\u003c/b\u003e - 1 г/сут в 1-й день за 1 прием, далее по 500 мг/сут ежедневно со 2 по 5 день, курсовая доза - 3 г; \u003cb\u003eдетям\u003c/b\u003e - в 1-й день в дозе из расчета 20 мг/кг массы тела, затем со 2 по 5-й день - по 10 мг/кг массы тела."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота побочных эффектов классифицирована в соответствии с рекомендациями"}},{"type":"paragraph","data":{"text":"Всемирной организации здравоохранения: очень часто – не менее 10%, часто – не менее"}},{"type":"paragraph","data":{"text":"1%, но менее 10%, нечасто - не менее 0,1%, но менее 1%, редко - не менее 0,01%, но менее"}},{"type":"paragraph","data":{"text":"0,1%, очень редко - менее 0,01%; неизвестная частота - не может быть оценена, исходя из"}},{"type":"paragraph","data":{"text":"имеющихся данных."}},{"type":"paragraph","data":{"text":"Инфекционные заболевания: нечасто – кандидоз, в том числе слизистой оболочки полости"}},{"type":"paragraph","data":{"text":"рта, вагинальная инфекция, пневмония, фарингит, гастроэнтерит, респираторные "}},{"type":"paragraph","data":{"text":"заболевания, ринит, грибковая инфекция, бактериальная инфекция; неизвестная частота -"}},{"type":"paragraph","data":{"text":"псевдомембранозный колит."}},{"type":"paragraph","data":{"text":"Со стороны крови и лимфатической системы: нечасто - лейкопения, нейтропения,"}},{"type":"paragraph","data":{"text":"эозинофилия; очень редко - тромбоцитопения, гемолитическая анемия."}},{"type":"paragraph","data":{"text":"Со стороны обмена веществ и питания: нечасто - анорексия."}},{"type":"paragraph","data":{"text":"Аллергические реакции: нечасто - ангионевротический отек, реакция"}},{"type":"paragraph","data":{"text":"гиперчувствительности; неизвестная частота - анафилактическая реакция."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: часто - головная боль; нечасто - головокружение,"}},{"type":"paragraph","data":{"text":"нарушение вкусовых ощущений, парестезии, сонливость, бессонница, нервозность; редко"}},{"type":"paragraph","data":{"text":"- ажитация; неизвестная частота - гипестезия, тревога, агрессия, обморок, судороги,"}},{"type":"paragraph","data":{"text":"психомоторная гиперактивность, потеря обоняния, извращенное обоняние, потеря"}},{"type":"paragraph","data":{"text":"вкусовых ощущений, миастения, бред, галлюцинации."}},{"type":"paragraph","data":{"text":"Со стороны органа зрения: нечасто - нарушение зрения."}},{"type":"paragraph","data":{"text":"Со стороны органа слуха и лабиринтные нарушения: нечасто - расстройство слуха,"}},{"type":"paragraph","data":{"text":"вертиго; неизвестная частота - нарушение слуха, в том числе глухота и/или шум в ушах."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: нечасто - ощущение сердцебиения,"}},{"type":"paragraph","data":{"text":"«приливы» крови к лицу; неизвестная частота - понижение артериального давления,"}},{"type":"paragraph","data":{"text":"увеличение интервала QT на электрокардиограмме, аритмия типа «пируэт», желудочковая"}},{"type":"paragraph","data":{"text":"тахикардия."}},{"type":"paragraph","data":{"text":"Со стороны дыхательной системы: нечасто - одышка, носовое кровотечение."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: очень часто - диарея; часто - тошнота, рвота,"}},{"type":"paragraph","data":{"text":"боль в животе; нечасто - метеоризм, диспепсия, запор, гастрит, дисфагия, вздутие живота,"}},{"type":"paragraph","data":{"text":"сухость слизистой оболочки полости рта, отрыжка, язвы слизистой оболочки полости рта,"}},{"type":"paragraph","data":{"text":"повышение секреции слюнных желез; очень редко - изменение цвета языка, панкреатит."}},{"type":"paragraph","data":{"text":"Со стороны печени и желчевыводящих путей: нечасто - гепатит; редко - нарушение"}},{"type":"paragraph","data":{"text":"функции печени, холестатическая желтуха; неизвестная частота - печеночная"}},{"type":"paragraph","data":{"text":"недостаточность (в редких случаях с летальным исходом в основном на фоне тяжелого"}},{"type":"paragraph","data":{"text":"нарушения функции печени); некроз печени, фульминантный гепатит."}},{"type":"paragraph","data":{"text":"Со стороны кожи и подкожных тканей: нечасто - кожная сыпь, зуд, крапивница,"}},{"type":"paragraph","data":{"text":"дерматит, сухость кожи, потливость; редко - реакция фотосенсибилизации, острый"}},{"type":"paragraph","data":{"text":"генерализованный экзантематозный пустулез; неизвестная частота - синдром СтивенсаДжонсона, токсический эпидермальный некролиз, мультиформная эритема, лекарственная"}},{"type":"paragraph","data":{"text":"сыпь с эозинофилией и системными проявлениями (DRESS-синдром)."}},{"type":"paragraph","data":{"text":"Со стороны опорно-двигательного аппарата: нечасто - остеоартрит, миалгия, боль в"}},{"type":"paragraph","data":{"text":"спине, боль в шее; неизвестная частота - артралгия. "}},{"type":"paragraph","data":{"text":"Со стороны почек и мочевыводящих путей: нечасто - дизурия, боль в области почек;"}},{"type":"paragraph","data":{"text":"неизвестная частота - интерстициальный нефрит, острая почечная недостаточность. Со"}},{"type":"paragraph","data":{"text":"стороны половых органов и молочной железы: нечасто - метроррагии, нарушение"}},{"type":"paragraph","data":{"text":"функции яичек."}},{"type":"paragraph","data":{"text":"Прочие: нечасто - астения, недомогание, ощущение усталости, отек, отек лица, боль в"}},{"type":"paragraph","data":{"text":"груди, лихорадка, периферические отеки."}},{"type":"paragraph","data":{"text":"Лабораторные и инструментальные данные: часто – снижение количества лимфоцитов,"}},{"type":"paragraph","data":{"text":"повышение количества эозинофилов, повышение количества базофилов, повышение"}},{"type":"paragraph","data":{"text":"количества моноцитов, повышение количества нейтрофилов, снижение концентрации"}},{"type":"paragraph","data":{"text":"бикарбонатов в плазме крови; нечасто - повышение активности"}},{"type":"paragraph","data":{"text":"аспартатаминотрансферазы, аланинаминотрансферазы, повышение концентрации"}},{"type":"paragraph","data":{"text":"билирубина в плазме крови, повышение концентрации мочевины в плазме крови,"}},{"type":"paragraph","data":{"text":"повышение концентрации креатинина в плазме крови, изменение содержания калия в"}},{"type":"paragraph","data":{"text":"плазме крови, повышение активности щелочной фосфатазы в плазме крови, повышение"}},{"type":"paragraph","data":{"text":"содержания хлора в плазме крови, повышение концентрации глюкозы в крови,"}},{"type":"paragraph","data":{"text":"увеличение количества тромбоцитов, снижение гематокрита, повышение концентрации"}},{"type":"paragraph","data":{"text":"бикарбонатов в плазме крови, изменение содержания натрия в плазме крови.\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: тошнота, временная потеря слуха, рвота, диарея."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Антацидные препараты"}},{"type":"paragraph","data":{"text":"Антацидные препараты не влияют на биодоступность азитромицина, но уменьшают"}},{"type":"paragraph","data":{"text":"максимальную концентрацию в крови на 30%, поэтому препарат следует принимать, по"}},{"type":"paragraph","data":{"text":"крайней мере, за один час до или через два часа после приема этих препаратов и еды."}},{"type":"paragraph","data":{"text":"Цетиризин"}},{"type":"paragraph","data":{"text":"Одновременное применение в течение 5 дней у здоровых добровольцев азитромицина с"}},{"type":"paragraph","data":{"text":"цетиризином (20 мг) не привело к фармакокинетическому взаимодействию и"}},{"type":"paragraph","data":{"text":"существенному изменению интервала QT."}},{"type":"paragraph","data":{"text":"Диданозин (дидезоксиинозин)"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина (1200 мг/сут) и диданозина (400 мг/сут) у 6"}},{"type":"paragraph","data":{"text":"ВИЧ-инфицированных пациентов не выявило изменений фармакокинетических"}},{"type":"paragraph","data":{"text":"показателей диданозина по сравнению с группой плацебо."}},{"type":"paragraph","data":{"text":"Дигоксин и колхицин (субстраты Р-гликопротеина)"}},{"type":"paragraph","data":{"text":"Одновременное применение макролидных антибиотиков, в том числе азитромицина, с"}},{"type":"paragraph","data":{"text":"субстратами Р-гликопротеина, такими как дигоксин и колхицин, приводит к повышению"}},{"type":"paragraph","data":{"text":"концентрации субстрата Р-гликопротеина в сыворотке крови. Таким образом, при"}},{"type":"paragraph","data":{"text":"одновременном применении азитромицина и дигоксина необходимо учитывать"}},{"type":"paragraph","data":{"text":"возможность повышения дигоксина в сыворотке крови."}},{"type":"paragraph","data":{"text":"Зидовудин"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина (одноразовый прием 1000 мг и многократный"}},{"type":"paragraph","data":{"text":"прием 1200 мг или 600 мг) оказывает незначительное влияние на фармакокинетику, в том"}},{"type":"paragraph","data":{"text":"числе выведение почками, зидовудина или его глюкуронидного метаболита. Однако"}},{"type":"paragraph","data":{"text":"применение азитромицина вызывало увеличение концентрации фосфорилированного"}},{"type":"paragraph","data":{"text":"зидовудина, клинически активного метаболита в мононуклеарах периферической крови."}},{"type":"paragraph","data":{"text":"Клиническое значение этого факта неясно."}},{"type":"paragraph","data":{"text":"Азитромицин слабо взаимодействует с изоферментами системы цитохрома Р450. Не"}},{"type":"paragraph","data":{"text":"выявлено, что азитромицин участвует в фармакокинетических взаимодействиях"}},{"type":"paragraph","data":{"text":"аналогичных эритромицину и другим макролидам. Азитромицин не является ингибитором"}},{"type":"paragraph","data":{"text":"и индуктором изоферментов цитохрома Р450."}},{"type":"paragraph","data":{"text":"Алкалоиды спорыньи"}},{"type":"paragraph","data":{"text":"Учитывая теоретическую возможность возникновения эрготизма, одновременное"}},{"type":"paragraph","data":{"text":"применение азитромицина с производными алкалоидов спорыньи не рекомендуется."}},{"type":"paragraph","data":{"text":"Были проведены фармакокинетические исследования одновременного применения"}},{"type":"paragraph","data":{"text":"азитромицина и препаратов, метаболизм которых происходит с участием изоферментов"}},{"type":"paragraph","data":{"text":"системы цитохрома Р450."}},{"type":"paragraph","data":{"text":"Аторвастатин"}},{"type":"paragraph","data":{"text":"Одновременное применение аторвастатина (10 мг ежедневно) и азитромицина (500 мг"}},{"type":"paragraph","data":{"text":"ежедневно) не вызывало изменения концентраций аторвастатина в плазме крови (на"}},{"type":"paragraph","data":{"text":"основе анализа ингибирования ГМК-КоА-редуктазы). Однако, в пострегистрационном"}},{"type":"paragraph","data":{"text":"периоде были получены отдельные сообщения о случаях рабдомиолиза у пациентов,"}},{"type":"paragraph","data":{"text":"получающих одновременно азитромицин и статины."}},{"type":"paragraph","data":{"text":"Карбамазепин"}},{"type":"paragraph","data":{"text":"В фармакокинетических исследованиях с участием здоровых добровольцев не выявлено"}},{"type":"paragraph","data":{"text":"существенного влияния на концентрацию карбамазепина и его активного метаболита в"}},{"type":"paragraph","data":{"text":"плазме крови у пациентов, получавших одновременно азитромицин."}},{"type":"paragraph","data":{"text":"Циметидин"}},{"type":"paragraph","data":{"text":"В фармакокинетических исследованиях влияния разовой дозы циметидина на "}},{"type":"paragraph","data":{"text":"фармакокинетику азитромицина не выявлено изменений фармакокинетики азитромицина,"}},{"type":"paragraph","data":{"text":"при условии применения циметидина за 2 часа до азитромицина."}},{"type":"paragraph","data":{"text":"Антикоагулянты непрямого действия (производные кумарина)"}},{"type":"paragraph","data":{"text":"В фармакокинетических исследованиях азитромицин не влиял на антикоагулянтный"}},{"type":"paragraph","data":{"text":"эффект однократной дозы 15 мг варфарина, принимаемого здоровыми добровольцами."}},{"type":"paragraph","data":{"text":"Сообщалось о потенцировании антикоагулянтного эффекта после одновременного"}},{"type":"paragraph","data":{"text":"применения азитромицина и антикоагулянтов непрямого действия (производные"}},{"type":"paragraph","data":{"text":"кумарина). Несмотря на то, что причинная связь не установлена, следует учитывать"}},{"type":"paragraph","data":{"text":"необходимость проведения частого мониторинга протромбинового времени при"}},{"type":"paragraph","data":{"text":"применении азитромицина у пациентов, которые получают пероральные антикоагулянты"}},{"type":"paragraph","data":{"text":"непрямого действия (производные кумарина)."}},{"type":"paragraph","data":{"text":"Циклоспорин"}},{"type":"paragraph","data":{"text":"В фармакокинетическом исследовании с участием здоровых добровольцев, которые в"}},{"type":"paragraph","data":{"text":"течение 3 дней принимали внутрь азитромицин (500 мг/сут однократно), а затем"}},{"type":"paragraph","data":{"text":"циклоспорин (10 мг/кг/сут однократно), было выявлено достоверное повышение"}},{"type":"paragraph","data":{"text":"максимальной концентрации в плазме крови (Cmax) и площади под кривой"}},{"type":"paragraph","data":{"text":"«концентрация-время» (AUC0-5) циклоспорина. Следует соблюдать осторожность при"}},{"type":"paragraph","data":{"text":"одновременном применении этих препаратов. В случае необходимости одновременного"}},{"type":"paragraph","data":{"text":"применения этих препаратов, необходимо проводить мониторинг концентрации"}},{"type":"paragraph","data":{"text":"циклоспорина в плазме крови и соответственно корректировать дозу."}},{"type":"paragraph","data":{"text":"Эфавиренз"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина (600 мг/сут однократно) и эфавиренза"}},{"type":"paragraph","data":{"text":"(400 мг/сут) ежедневно в течение 7 дней не вызывало какого-либо клинически значимого"}},{"type":"paragraph","data":{"text":"фармакокинетического взаимодействия."}},{"type":"paragraph","data":{"text":"Флуконазол"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина (1200 мг однократно) не меняло"}},{"type":"paragraph","data":{"text":"фармакокинетику флуконазола (800 мг однократно). Общая экспозиция и период"}},{"type":"paragraph","data":{"text":"полувыведения азитромицина не изменялись при одновременном применении"}},{"type":"paragraph","data":{"text":"флуконазола, однако при этом наблюдали снижение Cmax азитромицина (на 18%), что не"}},{"type":"paragraph","data":{"text":"имело клинического значения."}},{"type":"paragraph","data":{"text":"Индинавир"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина (1200 мг однократно) не вызывало"}},{"type":"paragraph","data":{"text":"статистически достоверного влияния на фармакокинетику индинавира (по 800 мг три раза"}},{"type":"paragraph","data":{"text":"в сутки в течение 5 дней)."}},{"type":"paragraph","data":{"text":"Метилпреднизолон"}},{"type":"paragraph","data":{"text":"Азитромицин не оказывает существенного влияния на фармакокинетику"}},{"type":"paragraph","data":{"text":"метилпреднизолона."}},{"type":"paragraph","data":{"text":"Нелфинавир"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина (1200 мг) и нелфинавира (по 750 мг 3 раза в"}},{"type":"paragraph","data":{"text":"день) вызывает повышение равновесных концентраций азитромицина в сыворотке крови."}},{"type":"paragraph","data":{"text":"Клинически значимых побочных эффектов не наблюдалось и коррекции дозы"}},{"type":"paragraph","data":{"text":"азитромицина при его одновременном применении с нелфинавиром не требуется."}},{"type":"paragraph","data":{"text":"Рифабутин"}},{"type":"paragraph","data":{"text":"Одновременное применение азитромицина и рифабутина не влияет на концентрацию"}},{"type":"paragraph","data":{"text":"каждого из препаратов в сыворотке крови. При одновременном применении азитромицина"}},{"type":"paragraph","data":{"text":"и рифабутина иногда наблюдалась нейтропения. Несмотря на то, что нейтропения"}},{"type":"paragraph","data":{"text":"ассоциировалась с применением рифабутина, причинно-следственная связь между"}},{"type":"paragraph","data":{"text":"применением комбинации азитромицина и рифабутина и нейтропенией не установлена."}},{"type":"paragraph","data":{"text":"Силденафил"}},{"type":"paragraph","data":{"text":"При применении у здоровых добровольцев не получено доказательств влияния"}},{"type":"paragraph","data":{"text":"азитромицина (500 мг/сут ежедневно в течение 3 дней) на AUC и Cmax силденафила или"}},{"type":"paragraph","data":{"text":"его основного циркулирующего метаболита."}},{"type":"paragraph","data":{"text":"Терфенадин"}},{"type":"paragraph","data":{"text":"В фармакокинетических исследованиях не было получено доказательств взаимодействия"}},{"type":"paragraph","data":{"text":"между азитромицином и терфенадином. Сообщалось о единичных случаях, когда"}},{"type":"paragraph","data":{"text":"возможность такого взаимодействия нельзя было исключить полностью, однако не было"}},{"type":"paragraph","data":{"text":"ни одного конкретного доказательства, что такое взаимодействие имело место."}},{"type":"paragraph","data":{"text":"Было установлено, что одновременное применение терфенадина и макролидов может"}},{"type":"paragraph","data":{"text":"вызвать аритмию и удлинение интервала QT."}},{"type":"paragraph","data":{"text":"Теофиллин"}},{"type":"paragraph","data":{"text":"Не выявлено взаимодействие между азитромицином и теофиллином."}},{"type":"paragraph","data":{"text":"Триазолам/мидазолам"}},{"type":"paragraph","data":{"text":"Значительных изменений фармакокинетических показателей при одновременном"}},{"type":"paragraph","data":{"text":"применении азитромицина с триазоламом или мидазоламом в терапевтических дозах не"}},{"type":"paragraph","data":{"text":"выявлено."}},{"type":"paragraph","data":{"text":"Триметоприм/сульфаметоксазол"}},{"type":"paragraph","data":{"text":"Одновременное применение триметоприма/сульфаметоксазола с азитромицином не"}},{"type":"paragraph","data":{"text":"выявило существенного влияния на Cmax, общую экспозицию или экскрецию почками"}},{"type":"paragraph","data":{"text":"триметоприма или сульфаметоксазола. Концентрации азитромицина в сыворотке крови"}},{"type":"paragraph","data":{"text":"соответствовали выявляемым в других исследованиях."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность. Также как при применении эритромицина и других макролидов,"}},{"type":"paragraph","data":{"text":"сообщалось о редких случаях серьезных аллергических реакций, включая"}},{"type":"paragraph","data":{"text":"ангионевротический отек и анафилаксию (в редких случаях с летальным исходом),"}},{"type":"paragraph","data":{"text":"кожных реакций, включая острый генерализованный экзантематозный пустулез, синдром"}},{"type":"paragraph","data":{"text":"Стивенса-Джонсона, токсический эпидермальный некролиз (в редких случаях с"}},{"type":"paragraph","data":{"text":"летальным исходом), лекарственную сыпь с эозинофилией и системными проявлениями"}},{"type":"paragraph","data":{"text":"(DRESS-синдром). Некоторые из таких реакций, развившихся при применении"}},{"type":"paragraph","data":{"text":"азитромицина, приобретали рецидивирующее течение и требовали продолжительного"}},{"type":"paragraph","data":{"text":"лечения и наблюдения."}},{"type":"paragraph","data":{"text":"При развитии аллергической реакции препарат следует отменить и начать"}},{"type":"paragraph","data":{"text":"соответствующее лечение. Следует иметь в виду, что после отмены симптоматической"}},{"type":"paragraph","data":{"text":"терапии возможно возобновление симптомов аллергической реакции."}},{"type":"paragraph","data":{"text":"В случае пропуска приема одной дозы препарата – пропущенную дозу следует принять"}},{"type":"paragraph","data":{"text":"как можно раньше, а последующие – с перерывами в 24 ч."}},{"type":"paragraph","data":{"text":"Азитромицин следует принимать, по крайней мере, за один час до или через два часа"}},{"type":"paragraph","data":{"text":"после приема антацидных препаратов."}},{"type":"paragraph","data":{"text":"Азитромицин следует применять с осторожностью у пациентов с нарушениями функции"}},{"type":"paragraph","data":{"text":"печени легкой и средней степени тяжести из-за возможности развития фульминантного"}},{"type":"paragraph","data":{"text":"гепатита и тяжелой печеночной недостаточности."}},{"type":"paragraph","data":{"text":"При наличии симптомов нарушения функции печени, таких как быстро нарастающая"}},{"type":"paragraph","data":{"text":"астения, желтуха, потемнение мочи, склонность к кровотечениям, печеночная"}},{"type":"paragraph","data":{"text":"энцефалопатия, терапию препаратом следует прекратить и провести исследование"}},{"type":"paragraph","data":{"text":"функционального состояния печени."}},{"type":"paragraph","data":{"text":"При нарушениях функции почек: у пациентов с СКФ 10-80 мл/мин коррекции дозы не"}},{"type":"paragraph","data":{"text":"требуется; терапию препаратом Хемомицин следует проводить с осторожностью под"}},{"type":"paragraph","data":{"text":"контролем состояния функции почек у пациентов с СКФ менее 10 мл/мин."}},{"type":"paragraph","data":{"text":"Как и при применении других антибактериальных препаратов, при терапии"}},{"type":"paragraph","data":{"text":"азитромицином следует регулярно обследовать пациентов на наличие невосприимчивых"}},{"type":"paragraph","data":{"text":"микроорганизмов и признаки развития суперинфекций, в том числе грибковых."}},{"type":"paragraph","data":{"text":"Препарат не следует применять более длительными курсами, чем указано в инструкции,"}},{"type":"paragraph","data":{"text":"так как фармакокинетические свойства азитромицина позволяют рекомендовать короткий"}},{"type":"paragraph","data":{"text":"и простой режим дозирования."}},{"type":"paragraph","data":{"text":"Нет данных о возможном взаимодействии между азитромицином и производными "}},{"type":"paragraph","data":{"text":"эрготамина и дигидроэрготамина, но из-за развития эрготизма при одновременном"}},{"type":"paragraph","data":{"text":"применении макролидов с производными эрготамина и дигидроэрготамина данная"}},{"type":"paragraph","data":{"text":"комбинация не рекомендована."}},{"type":"paragraph","data":{"text":"При длительном приеме азитромицина возможно развитие псевдомембранозного колита,"}},{"type":"paragraph","data":{"text":"вызванного Clostridium difficile, как в виде легкой диареи, так и тяжелого колита. При"}},{"type":"paragraph","data":{"text":"развитии антибиотик-ассоциированной диареи на фоне приема препарата, а также через 2"}},{"type":"paragraph","data":{"text":"месяца после окончания терапии следует исключить клостридиальный"}},{"type":"paragraph","data":{"text":"псевдомембранозный колит. Нельзя применять лекарственные препараты, тормозящие"}},{"type":"paragraph","data":{"text":"перистальтику кишечника."}},{"type":"paragraph","data":{"text":"При лечении макролидами, в том числе азитромицином, наблюдалось удлинение"}},{"type":"paragraph","data":{"text":"сердечной реполяризации и интервала QT, повышающих риск развития сердечных"}},{"type":"paragraph","data":{"text":"аритмий, в том числе аритмии типа «пируэт», которые могут привести к остановке сердца."}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при применении препарата у пациентов с наличием"}},{"type":"paragraph","data":{"text":"проаритмогенных факторов (особенно у пожилых пациентов): с врожденным или"}},{"type":"paragraph","data":{"text":"приобретенным удлинением интервала QT, у пациентов, получающих терапию"}},{"type":"paragraph","data":{"text":"антиаритмическими препаратами классов IA (хинидин, прокаинамид), III (дофетилид,"}},{"type":"paragraph","data":{"text":"амиодарон и соталол), цизапридом, терфенадином, антипсихотическими препаратами"}},{"type":"paragraph","data":{"text":"(пимозид), антидепрессантами (циталопрам), фторхинолонами (моксифлоксацин и"}},{"type":"paragraph","data":{"text":"левофлоксацин), с нарушениями водно-электролитного баланса, особенно в случае"}},{"type":"paragraph","data":{"text":"гипокалиемии или гипомагниемии, с клинически значимой брадикардией, аритмией"}},{"type":"paragraph","data":{"text":"сердца, или тяжелой сердечной недостаточностью."}},{"type":"paragraph","data":{"text":"Применение азитромицина может спровоцировать развитие миастенического синдрома"}},{"type":"paragraph","data":{"text":"или вызвать обострение миастении."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В связи с возможным развитием на фоне лечения нежелательных реакций со стороны"}},{"type":"paragraph","data":{"text":"центральной нервной системы и органа зрения, необходимо соблюдать осторожность при"}},{"type":"paragraph","data":{"text":"управлении транспортными средствами и выполнении других видов деятельности,"}},{"type":"paragraph","data":{"text":"требующих повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Порошок для приготовления суспензии для приема внутрь 200 мг/5 мл."}},{"type":"paragraph","data":{"text":"10 г порошка во флакон темного стекла вместимостью 60 мл, укупоренный"}},{"type":"paragraph","data":{"text":"навинчивающейся, с контролем первого вскрытия пластиковой или металлической "}},{"type":"paragraph","data":{"text":"крышкой. На верхнюю сторону пластиковой крышки нанесена схема открывания"}},{"type":"paragraph","data":{"text":"флакона."}},{"type":"paragraph","data":{"text":"Флакон вместе с мерной ложкой (объемом 5 мл, с риской для объема 2,5 мл) и"}},{"type":"paragraph","data":{"text":"инструкцией по применению вкладывают в картонную пачку."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 ºС в потребительской упаковке."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать после истечения срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Хемофарм А.Д. Вршац, отделение Производственная площадка Шабац, Сербия"}},{"type":"paragraph","data":{"text":"15000, г. Шабац, ул. Хайдук Велькова бб"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО «Нижфарм», Россия"}},{"type":"paragraph","data":{"text":"603950, г. Нижний Новгород, ул. Салганская, д. 7"}},{"type":"paragraph","data":{"text":"Тел.: (831) 278-80-88; факс: (831) 430-72-28"}},{"type":"paragraph","data":{"text":"E-mail: med@stada.ru"}}]}],"source":null},"description_toggle":false,"short_description":"Антибиотик широкого спектра действия. Азитромицин является представителем подгруппы макролидных антибиотиков - азалидов. В высоких концентрациях оказывает бактерицидное действие. Хемомицинактивен в отношении аэробных грамположительных бактерий:Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus spp. групп C, F и G, Streptococcus viridans, Staphylococcus aureus;аэробных грамотрицательных бактерий:Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertussis, Legionella pneumophila, Haemophilus ducreyi, Helicobacter pylori, Campylobacter jejuni, Neisseria gonorrhoeae и Gardnerella vaginalis;анаэробных бактерий:Bacteroides bivius, Clostridium perfringens, Peptostreptococcus spp. Препаратактивен в отношениивнутриклеточных микроорганизмов:Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Borrelia burgdorferi, атакже в отношенииTreponema pallidum. 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