Купирование симптомов, являющихся следствием дефицита эстрогена и прогестерона у женщин в климактерическом периоде; - Профилактика остеопороза у женщин в постменопаузе.
Противопоказания
тромбоэмболические нарушения или патология сосудов головного мозга в анамнезе (в т.ч. в семейном); - серповидно-клеточная анемия; - опухоли гипофиза; - эстрогенозависимые опухоли (рак молочной железы, матки); - острые и хронические заболевания печени; - эндометриоз; - артериальная гипертензия, резистентная к терапии; - беременность.
Комбинированный гормонозамещающий препарат непрерывного действия, в состав которого входят естественный эстроген - эстрадиола валерат и дериват естественного прогестерона - медроксипрогестерона ацетат.; Введение комбинации эстрадиола валерат/медроксипрогестерона ацетат близко имитирует естественный цикл гормональной активности, характерный для нормального менструального цикла, т.е. эстрогенная фаза предшествует комбинированной эстроген/прогестагенной фазе, за которой следует менструальноподобное кровотечение, возникающее в течение 1 недели после последнего приема препарата.; После 12 мес применения Дивины исчезают приливы и усиление потоотделения в ночное время.; У женщин в климактерическом периоде на фоне приема Дивины не снижается содержание минералов и плотность костной ткани, т.е. предотвращается развитие остеопороза.; Препарат обладает благоприятным действием на уровень липидов в крови: снижает уровень липопротеидов низкой плотности и холестерина, уменьшает риск развития атеросклероза; повышает уровень липопротеидов высокой плотности, которые обладают антиатерогенным эффектом.; Применение Дивины предупреждает развитие гиперплазии и малигнизации эндометрия.
Показания к применению
Купирование симптомов, являющихся следствием дефицита эстрогена и прогестерона у женщин в климактерическом периоде; - Профилактика остеопороза у женщин в постменопаузе.
Противопоказания
тромбоэмболические нарушения или патология сосудов головного мозга в анамнезе (в т.ч. в семейном); - серповидно-клеточная анемия; - опухоли гипофиза; - эстрогенозависимые опухоли (рак молочной железы, матки); - острые и хронические заболевания печени; - эндометриоз; - артериальная гипертензия, резистентная к терапии; - беременность.
Применение при беременности и в период грудного вскармливания
Дивина противопоказана к применению при беременности.; Препарат не может быть использован в качестве контрацептивного средства.
Способ применения и дозы
Внутрь по 1 таб./сут (предпочтительнее вечером) в течение 21 дня, затем следует 7-дневный перерыв, во время которого наступает менструальноподобное кровотечение, после чего вновь начинают прием таблеток (см. маркировку на упаковке с календарной шкалой).; В течение первых 11 дней принимают таблетки, содержащие только эстроген (белые).; Затем в течение оставшихся 10 дней - таблетки, содержащие комбинацию эстрогена с прогестероном (голубые).; Прием таблеток можно начинать в любое время, если нормальный менструальный цикл прекратился или если он нерегулярен, а также на 5-й день менструации.; В случае пропуска приема таблетки ее следует принять не позднее 12 ч и далее принимать препарат по обычной схеме.
Побочное действие
Со стороны половой системы: редко - нарушение регулярности кровотечений (метроррагии), нагрубание молочных желез.; Со стороны ЦНС: редко - головная боль, повышенная утомляемость.; Со стороны пищеварительной системы: редко - тошнота.; Прочие: редко - ощущение тяжести в нижних конечностях.
В климактерический период возможны различия в продолжительности менструального цикла, поэтому у некоторых женщин кровотечение может начаться еще во время приема голубых таблеток препарата Дивина. В этих случаях необходимо временно прекратить прием препарата, а после окончания кровотечения возобновить прием белых таблеток.; Влияние на способность к вождению автотранспорта и управлению механизмами; Дивина не влияет на способность к вождению автомобиля и занятиям другими видами деятельности, требующей повышенного внимания и быстроты психомоторных реакций.
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