Раствор для в/м введения Спазмалгон - спазмоанальгетик комбинированного состава, сочетание компонентов которого приводит к взаимному усилению их фармакологического действия. Метамизол натрий - анальгетик-антипиретик, производное пиразолона. Оказывает выраженное анальгезирующее, жаропонижающее и слабое противовоспалительное действие, механизм которого связан с угнетением синтеза простагландинов. Питофенона гидрохлорид - миотропный спазмолитик, оказывает прямое действие на гладкую мускулатуру внутренних органов и вызывает ее расслабление (папавериноподобное действие). Фенпивериния бромид, являясь м-холиноблокатором, оказывает дополнительное расслабляющее действие на гладкую мускулатуру.
Фармакологические свойства
Спазмалгон является комбинированным препаратом с выраженнойспазмолитической и анальгетической активностью, также оказываетпротивовоспалительное действие. Метамизол натрия обладает выраженным анальгетическим иантипиретическим действием в сочетании с известной противовоспалительной испазмолитической активностью. Его эффекты являются результатом выраженногоантиноцицептивного действия, влияния на гипоталамус и образование эндогенныхпирогенов, а также торможение синтезапростагландинов в результате ингибиции циклооксигеназы. Фенпивериния бромид обладает умеренно выраженнымганглиоблокирующим действием и действием на м-холинорецепторы, вызывая, такимобразом, понижение тонуса и моторики гладкой мускулатуры желудка, кишечника, желчных и мочевыводящих путей. Питофенона гидрохлорид оказывает папавериноподобное действиес выраженной миотропной спазмолитической активностью на гладкую мускулатуру.
Показания к применению
Симптоматическое лечение болевого синдрома при спазмахгладкой мускулатуры внутренних органов:- желудочные или кишечные колики- почечные колики при мочекаменной болезни- спастическая дискинезия желчных путей- дисменорея
Противопоказания
Угнетение костномозгового кроветворения,
Выраженная печеночная недостаточность,
Выраженная почечная недостаточность,
Дефицит глюкозо-6-фосфатдегидрогеназы,
Тахиаритмия,
Тяжелая стенокардия,
Сердечная недостаточность в стадии декомпенсации,
Закрытоугольная глаукома,
Гиперплазия предстательной железы с клиническими проявлениями,
Кишечная непроходимость,
Мегаколон,
Коллапс,
Беременность (особенно I и III триместр),
Период лактации (грудное вскармливание),
Детский возраст до 15 лет,
Повышенная чувствительность к компонентам препарата и другим производным пиразолона
Способ применения и дозы
Спазмалгон вводят внутримышечно. Разовая доза варьирует от 2 до 5 мл в зависимости от вида и тяжести клинической симптоматики. При наличиипоказаний инъекцию можно повторить через 6-8 ч. Но продолжительность подобногоприменения не должна превышать 2-3 суток. При отсутствии терапевтическогоэффекта следует отменить применение препарата, а при хорошем илиудовлетворительном эффекте можно перейти к приему пероральной лекарственнойформы. Максимальная суточная доза не должна превышать 10 млинъекционного раствора (соответственно 5 г метамизола натрия). Продолжительность лечебного курса определяет лечащий врач.
Побочное действие
снижение артериального давления, тахикардия, нарушение сердечного ритма- агранулоцитоз, лейкопения, тромбоцитопения- головокружение- зрительные нарушения, нарушение аккомодации- сухость во рту, обстипация (запор), обострение гастрита иязвенной болезни желудка- задержка мочи, протеинурия, олигурия, полиурия, интерстициальный нефрит, окрашиваниемочи в красный цвет- бронхоспазм- уртикария, крапивница, зуд, синдром Лайелла и синдром Стивенса- Джонсона, токсический эпидермальный некролиз, анафилактический шок
Передозировка
Симптомы: тошнота, рвота, гастралгия, олигурия, гипотермия, снижение АД, тахикардия, одышка, шум в ушах, сонливость, бред, нарушения сознания, острый агранулоцитоз, геморрагический синдром. Лечение: промывание желудка, прием активированного угля, применение водно-солевых растворов.
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