Этамзилат является гемостатическим лекарственным препаратом. Инструкция
Показания к применению
Профилактика и остановка кровотечений: паренхиматозные и капиллярные кровотечения (в т.ч. травматическое в хирургии при операциях на сильно васкуляризированных органах и тканях при оперативных вмешательствах в стоматологической урологической офтальмологической отоларингологической практике кишечное почечное легочное кровотечения метро- и меноррагии ...
Прозрачная бесцветная или слегка окрашенная жидкость.
Фармакотерапевтическая группа
гемостатическое средство
Фармакологические свойства
Фармакодинамика:
Этамзилат является гемостатическим лекарственным препаратом. Кровоостанавливающее действие основано на усилении взаимодействия между эндотелием и тромбоцитами. Повышает адгезию тромбоцитов стабилизирует стенки капилляров снижая таким образом их проницаемость тормозит синтез простагландинов вызывающих дезагрегацию тромбоцитов вазодилатацию и увеличение проницаемости капилляров что сокращает время кровотечения и уменьшает кровопотери. Увеличивает скорость образования первичного тромба и усиливает его ретракцию практически не влияет на уровень фибриногена и протромбиновое время.
Восстанавливает патологически измененное время кровотечения. На нормальные параметры системы гемостаза не влияет.
Гемостатический эффект при внутривенном введении раствора Этамзилата наступает через 5-15 минут максимальный эффект - через 1-2 часа. Действие продолжается в течение 4-6 часов затем в течение 24 ч постепенно ослабевает; при в/м введении эффект наступает несколько медленнее.
Фармакокинетика:
Препарат хорошо абсорбируется. Терапевтическая концентрация в крови - 005-002 мг/мл. Равномерно распределяется в различных органах и тканях (зависит от степени их кровоснабжения). Слабо связывается с белками плазмы и форменными элементами крови.
Быстро выводится из организма главным образом - почками (в неизмененном виде) а также с желчью. Период полувыведения после внутримышечного введения - 21 ч после внутривенного введения -19 ч.
Через 5 минут после внутривенного введения почками выделяется 20-30% введенного препарата полностью выводится через 4 ч.
Показания к применению
Профилактика и остановка кровотечений: паренхиматозные и капиллярные кровотечения (в т.ч. травматическое в хирургии при операциях на сильно васкуляризированных органах и тканях при оперативных вмешательствах в стоматологической урологической офтальмологической отоларингологической практике кишечное почечное легочное кровотечения метро- и меноррагии при фибромиоме и др.) вторичные кровотечения на фоне тромбоцитопении и тромбоцитопатии гипокоагуляция гематурия; внутричерепное кровоизлияние (в т.ч. у новорожденных и недоношенных детей); носовые кровотечения на фоне артериальной гипертензии кровотечения обусловленные приемом лекарственных средств геморрагический диатез (в т.ч. болезнь Верльгофа Виллебранда-Юргенса тромбоцитопатия) диабетическая микроангиопатия (геморрагическая диабетическая ретинопатия повторное кровоизлияние в сетчатку гемофтальм).
Противопоказания
Острая порфирия гемобластоз у детей гиперчувствительность к компонентам препарата; тромбоз; тромбоэмболия.
С осторожностью
При кровотечениях на фоне передозировки антикоагулянтов.
Применение при беременности и в период грудного вскармливания
Безопасность применения Этамзилата при беременности не установлена. Этамзилат следует применять во время беременности только в тех случаях если потенциальная польза для матери превышает возможный риск для плода.
Следует прекратить грудное вскармливание во время лечения матери препаратом Этамзилат.
Способ применения и дозы
Этамзилат вводят внутривенно внутримышечно. В офтальмологической практике - субконъюнктивально и ретробульбарно.
Взрослым: с профилактической целью при оперативных вмешательствах препарат вводят внутривенно или внутримышечно за 1 час до операции в дозе 250-500 мг (2-4 мл) при необходимости во время операций - в дозе 250-500 мг (2-4 мл) и профилактически - 500-750 мг (4-6 мл) внутривенно или внутримышечно равномерно в течение суток после операции.
Детям: при необходимости во время операции Этамзилат вводят внутривенно из расчета 8-10 мг/кг массы тела. Лечение можно начинать с первых дней жизни.
Для остановки кровотечения Этамзилат вводят внутривенно или внутримышечно 250-500 мг (2-4 мл) после чего каждые 4-6 часов по 250 мг (2 мл) в течение 5-10 дней.
При лечении метро-меноррагий Этамзилат назначают в разовой дозе 250 мг (2 мл) внутривенно или внутримышечно каждые 6-8 часов в течение 5-10 дней.
Геморрагии при диабетической микроангиопатии - внутримышечно по 250-500 мг (2-4 мл) 3 раза в день или по 125 мг (1 мл) 2 раза в день в течение 2-3 мес.
В офтальмологии Этамзилат вводят субконъюнктивально или ретробульбарно - в дозе 125 мг (1 мл).
Побочное действие
Изжога тяжесть в эпигастральной области головная боль головокружение гиперемия кожи лица снижение систолического АД парестезии нижних конечностей аллергические реакции.
Взаимодействие с другими лекарственными средствами
Фармацевтически несовместим (в одном шприце) с другими лекарственными средствами ЛС.
Введение в дозе 10 мг/кг за 1 час до декстранов (средняя мол. масса 30-40 тыс. Да) предотвращает их антиагрегантное действие; введение после не оказывает гемостатического действия.
Возможно сочетание с аминокапроновой кислотой и менадиона натрия бисульфитом.
Особые указания
Необходима осторожность (несмотря на отсутствие индукции тромбообразования) при назначении Этамзилата больным с тромбозами или тромбоэмболиями в анамнезе.
При геморрагических осложнениях связанных с передозировкой антикоагулянтов рекомендуется использовать специфические антидоты.
Использование Этамзилата у больных с нарушенными показателями свертывающей системы крови возможно но оно должно быть дополнено введением лекарственных средств устраняющих выявленный дефицит или дефект факторов свертывающей системы.
Влияние на способность управлять автомобилем и движущимися механизмами
О неблагоприятном влиянии препарата на способность управлять автомобилем и другими видами деятельности требующими концентраций внимания и быстроты психомоторных реакций не сообщалось.
Форма выпуска
Раствор для инъекций 125 мг/мл.
Условия хранения
В защищенном от света месте при температуре от 2 до 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Условия отпуска
По рецепту
Производитель
Акционерное общество "Новосибхимфарм" (АО "Новосибхимфарм"), 630028, г. Новосибирск, ул. Декабристов, д. 275, Россия
Организация, принимающая претензии потребителей
АО "Новосибхимфарм"
Для описания товара использована информация от партнера 36.6
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Кровоостанавливающее действие основано на усилении взаимодействия между эндотелием и тромбоцитами. Повышает адгезию тромбоцитов стабилизирует стенки капилляров снижая таким образом их проницаемость тормозит синтез простагландинов вызывающих дезагрегацию тромбоцитов вазодилатацию и увеличение проницаемости капилляров что сокращает время кровотечения и уменьшает кровопотери. Увеличивает скорость образования первичного тромба и усиливает его ретракцию практически не влияет на уровень фибриногена и протромбиновое время."}},{"type":"paragraph","data":{"text":"Восстанавливает патологически измененное время кровотечения. На нормальные параметры системы гемостаза не влияет."}},{"type":"paragraph","data":{"text":"Гемостатический эффект при внутривенном введении раствора Этамзилата наступает через 5-15 минут максимальный эффект - через 1-2 часа. Действие продолжается в течение 4-6 часов затем в течение 24 ч постепенно ослабевает; при в/м введении эффект наступает несколько медленнее."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Препарат хорошо абсорбируется. Терапевтическая концентрация в крови - 005-002 мг/мл. Равномерно распределяется в различных органах и тканях (зависит от степени их кровоснабжения). Слабо связывается с белками плазмы и форменными элементами крови."}},{"type":"paragraph","data":{"text":"Быстро выводится из организма главным образом - почками (в неизмененном виде) а также с желчью. Период полувыведения после внутримышечного введения - 21 ч после внутривенного введения -19 ч."}},{"type":"paragraph","data":{"text":"Через 5 минут после внутривенного введения почками выделяется 20-30% введенного препарата полностью выводится через 4 ч."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Профилактика и остановка кровотечений: паренхиматозные и капиллярные кровотечения (в т.ч. травматическое в хирургии при операциях на сильно васкуляризированных органах и тканях при оперативных вмешательствах в стоматологической урологической офтальмологической отоларингологической практике кишечное почечное легочное кровотечения метро- и меноррагии при фибромиоме и др.) вторичные кровотечения на фоне тромбоцитопении и тромбоцитопатии гипокоагуляция гематурия; внутричерепное кровоизлияние (в т.ч. у новорожденных и недоношенных детей); носовые кровотечения на фоне артериальной гипертензии кровотечения обусловленные приемом лекарственных средств геморрагический диатез (в т.ч. болезнь Верльгофа Виллебранда-Юргенса тромбоцитопатия) диабетическая микроангиопатия (геморрагическая диабетическая ретинопатия повторное кровоизлияние в сетчатку гемофтальм)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Острая порфирия гемобластоз у детей гиперчувствительность к компонентам препарата; тромбоз; тромбоэмболия."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При кровотечениях на фоне передозировки антикоагулянтов."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность применения Этамзилата при беременности не установлена. Этамзилат следует применять во время беременности только в тех случаях если потенциальная польза для матери превышает возможный риск для плода."}},{"type":"paragraph","data":{"text":"Следует прекратить грудное вскармливание во время лечения матери препаратом Этамзилат."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Этамзилат вводят внутривенно внутримышечно. В офтальмологической практике - субконъюнктивально и ретробульбарно."}},{"type":"paragraph","data":{"text":"Взрослым: с профилактической целью при оперативных вмешательствах препарат вводят внутривенно или внутримышечно за 1 час до операции в дозе 250-500 мг (2-4 мл) при необходимости во время операций - в дозе 250-500 мг (2-4 мл) и профилактически - 500-750 мг (4-6 мл) внутривенно или внутримышечно равномерно в течение суток после операции."}},{"type":"paragraph","data":{"text":"Детям: при необходимости во время операции Этамзилат вводят внутривенно из расчета 8-10 мг/кг массы тела. Лечение можно начинать с первых дней жизни."}},{"type":"paragraph","data":{"text":"Для остановки кровотечения Этамзилат вводят внутривенно или внутримышечно 250-500 мг (2-4 мл) после чего каждые 4-6 часов по 250 мг (2 мл) в течение 5-10 дней."}},{"type":"paragraph","data":{"text":"При лечении метро-меноррагий Этамзилат назначают в разовой дозе 250 мг (2 мл) внутривенно или внутримышечно каждые 6-8 часов в течение 5-10 дней."}},{"type":"paragraph","data":{"text":"Геморрагии при диабетической микроангиопатии - внутримышечно по 250-500 мг (2-4 мл) 3 раза в день или по 125 мг (1 мл) 2 раза в день в течение 2-3 мес."}},{"type":"paragraph","data":{"text":"В офтальмологии Этамзилат вводят субконъюнктивально или ретробульбарно - в дозе 125 мг (1 мл)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Изжога тяжесть в эпигастральной области головная боль головокружение гиперемия кожи лица снижение систолического АД парестезии нижних конечностей аллергические реакции."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Фармацевтически несовместим (в одном шприце) с другими лекарственными средствами ЛС."}},{"type":"paragraph","data":{"text":"Введение в дозе 10 мг/кг за 1 час до декстранов (средняя мол. масса 30-40 тыс. Да) предотвращает их антиагрегантное действие; введение после не оказывает гемостатического действия."}},{"type":"paragraph","data":{"text":"Возможно сочетание с аминокапроновой кислотой и менадиона натрия бисульфитом."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Необходима осторожность (несмотря на отсутствие индукции тромбообразования) при назначении Этамзилата больным с тромбозами или тромбоэмболиями в анамнезе."}},{"type":"paragraph","data":{"text":"При геморрагических осложнениях связанных с передозировкой антикоагулянтов рекомендуется использовать специфические антидоты."}},{"type":"paragraph","data":{"text":"Использование Этамзилата у больных с нарушенными показателями свертывающей системы крови возможно но оно должно быть дополнено введением лекарственных средств устраняющих выявленный дефицит или дефект факторов свертывающей системы."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"О неблагоприятном влиянии препарата на способность управлять автомобилем и другими видами деятельности требующими концентраций внимания и быстроты психомоторных реакций не сообщалось."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для инъекций 125 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре от 2 до 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"Новосибхимфарм\" (АО \"Новосибхимфарм\"), 630028, г. 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