Профилактика и лечение токсического действия метотрексата, передозировка антагонистов фолиевой кислоты. Лечение мегалобластной анемии, вызванной дефицитом фолиевой кислоты. Паллиативная терапия рака толстой и прямой кишки (в комбинации с фторурацилом).
Лейковорин-Лэнс назначается в качестве антидота лекарственных средств, которые действуют как антагонисты фолиевой кислоты. В частности для ликвидации последствий приема противоопухолевых препаратов. Выпущен в формате порошка для приготовления раствора, с последющим внутривенным или внутримышечным введением.
Фармакологические свойства
Антидот антагонистов фолиевой кислоты. Уменьшает терапевтическое и токсическое действие антагонистов фолиевой кислоты (например, метотрексата), способствует восстановлению биосинтеза нуклеиновых кислот и восполняет дефицит фолиевой кислоты в организме.
Показания к применению
Профилактика и лечение токсического действия метотрексата, передозировка антагонистов фолиевой кислоты. Лечение мегалобластной анемии, вызванной дефицитом фолиевой кислоты. Паллиативная терапия рака толстой и прямой кишки (в комбинации с фторурацилом).
Применение при беременности и в период грудного вскармливания
При необходимости применения во время беременности следует тщательно оценить предполагаемую пользу терапии для матери и потенциальный риск для плода. При необходимости применения в период лактации следует прекратить грудное вскармливание.
Способ применения и дозы
В связи с тем, что используются разные схемы применения Лейковорина-ЛЭНС, при выборе конкретной дозы врач должен руководствоваться специальной медицинской литературой. Обычно при назначении препарата в сочетании с высокими дозами метотрексата (12-15 г/м ) введение начинают через 24 часа после окончания лечения метотрексатом в дозе 10 мг/м2 каждые 6 часов в течение 72 часов или до достижения концентрации метотрексата в плазме крови менее 5x10 -8 М. При случайной передозировке метотрексата Лейковорин-ЛЭНС вводится в дозе равной или превышающей дозу введенного метотрексата не позднее, чем через 1 час после инъекции метотрексата, далее препарат вводится каждые 3 часа по 10 мг/м2 до исчезновения признаков токсичности. При лечении мегалобластной анемии, вызванной дефицитом фолиевой кислоты, Лейковорин-ЛЭНС назначают по 1 мг внутримышечно или внутривенно в сутки.
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