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В 0.1-1% случаев - одышка, кашель, раздражение гортани, повышение уровня аланинаминотрансферазы и аспартатаминотрансферазы, контактный дерматит, изменение окраски мочи, чувство жажды, возникновение синдрома постназального затека. Возможными побочными эффектами (частота неизвестна) являются: поражение роговицы, тахикардия, боль в груди. Травопрост: макулярный отек, увеит, ирит, конъюнктивит, фолликулез конъюнктивы, образование корок на краях век, усиление пигментации радужки, бронхиальная астма, шелушение кожи. 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Гемодиализ малоэффективен."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Анафилактические реакции Пациенты с атопией или с тяжелыми анафилактическими реакциями на различные аллергены в анамнезе, получающие бета-адреноблокаторы, могут быть резистентны к обычным дозам адреналина при лечении анафилактических реакций. Системные эффекты Травопрост и тимолол могут подвергаться системной абсорбции. Тимолол при местном использовании может вызывать такие же побочные эффекты со стороны сердечно-сосудистой и дыхательной систем, как и системные бета-адреноблокаторы. Следует контролировать состояние пациента до начала и во время терапии тимололом. Описаны случаи тяжелых дыхательных и сердечно-сосудистых расстройств, включая смерть от бронхоспазма у больных с бронхиальной астмой и смерть от сердечной недостаточности при использовании тимолола. Бета-адреноблокаторы следует с осторожностью назначать пациентам со склонностью к гипогликемии или диабетом (особенно с диабетом лабильного течения), поскольку эти препараты могут маскировать симптомы острой гипогликемии. Бета-адреноблокаторы могут маскировать симптомы гипертиреоза и вызывать периферические и центральные циркуляторные расстройства и гипотензию, а также ухудшение состояния при стенокардии Принцметала. Перед плановой операцией бета-адреноблокаторы должны быть постепенно (не одномоментно!) отменены за 48 ч до общей анестезии, т.к. во время общей анестезии они могут уменьшить чувствительность миокарда к симпатической стимуляции, необходимой для работы сердца. Местное действие Травопрост может вызывать постепенное изменение цвета глаз за счет увеличения количества коричневого пигмента в меланоцитах. До начала лечения больных следует проинформировать о возможности изменения цвета глаз. Лечение только одного глаза может привести к постоянной гетерохромии. Долгосрочное влияние на меланоциты и последствия этого влияния в настоящее время неизвестны. Изменение цвета радужки глаз происходит медленно и может оставаться незамеченным в течение ряда месяцев или лет. Этот эффект выявляется преимущественно у больных со смешанной окраской радужки, например, сине-коричневой, серо-коричневой, зелено-коричневой или желто-коричневой; однако также может наблюдаться у пациентов с карими глазами. Обычно коричневая пигментация распространяется концентрически вокруг зрачка к периферии радужки глаз, при этом вся радужка или ее части могут приобрести более интенсивный коричневый цвет. После отмены препарата не наблюдалось дальнейшего увеличения количества коричневою пигмента, однако уже развившееся изменение цвета может быть необратимым. Препарат может вызывать потемнение, утолщение и удлинение ресниц/или увеличение их количества; редко - потемнение кожи век. Механизм этих изменений в настоящее время не установлен. Препарат содержит консервант бензалкония хлорид, который может абсорбироваться контактными линзами. Перед применением препарата линзы следует снять и установить обратно не ранее, чем через 15 минут после применения препарата. Если у пациента после применения препарата временно снижается четкость зрения, до ее восстановления не рекомендуется управлять автомобилем и заниматься видами деятельности, требующими повышенного внимания. Не следует прикасаться кончиком флакон-капельницы к какой-либо поверхности, чтобы избежать загрязнения флакона-капельницы и его содержимого. Флакон необходимо закрывать после каждого использования."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Травопрост - синтетический аналог простагландина F2-альфа, является высокоселективным агонистом простагландиновых FP-рецепторов и снижает внутриглазное давление путем увеличения оттока водянистой влаги. Основной механизм действия препарата связан с увеличением увеосклерального оттока. Не оказывает существенного влияния на продукцию водянистой влаги. Тимолол - неселективный блокатор бета-адренорецепторов без симпатомиметической активности, не оказывает прямого депрессивного влияния на миокард, не обладает мембраностабилизирующей активностью. При местном применении снижает внутриглазное давление за счет уменьшения образования водянистой влаги и небольшого увеличения ее оттока. Внутриглазное давление снижается приблизительно через 2 ч после применения, а максимальный эффект достигается через 12 ч. Значительное снижение внутриглазного давления может сохраняться в течение 24 ч после однократного применения препарата.","substance":[{"id":332,"title":"Тимолол","title_latin":"Timololum","slug":"timolol_332"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Дуотрав - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/4870/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/4870/share_default/"}},"diseases":[{"id":"664","title":"Подозрение на глаукому (глазная гипертензия)","slug":"664-podozrenie_na_glaukomu_glaznaya_gipertenziya"},{"id":"665","title":"Первичная открытоугольная глаукома","slug":"665-pervichnaya_otkrytougolnaya_glaukoma"},{"id":"667","title":"Глаукома вторичная посттравматическая","slug":"667-glaukoma_vtorichnaya_posttravmaticheskaya"},{"id":"669","title":"Глаукома вторичная вследствие других болезней глаза","slug":"669-glaukoma_vtorichnaya_vsledstvie_drugih_bolezney_glaza"}],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Аналоги","type":"analogs","products":[{"id":103837,"title":"Окупрес-е","subtitle":{"full":"Капли, 5 мл, 0,5 %","short":"Капли, 5 мл, 0,5 %","package":"5 мл, 0,5 %"},"prescription":true,"catalog_section_id":53,"manufacturer":{"id":2449,"title":"Кадила","slug":"kadila_2449","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Капли","slug":"103837-okuprese","attributes":{"count":"","dose":"0,5 %","volume":"5 мл","spf":"","size":""},"image":{"isTouch":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/11725/phoneMedium_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/11725/phoneMedium_default/"},"isFromTablet":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/11725/tabletLarge_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/11725/tabletLarge_default/"}},"image_thumb":{"isTouch":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/11725/previewTouch_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/11725/previewTouch_default/"},"isFromTablet":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/11725/previewDesktopMedium_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/11725/previewDesktopMedium_default/"}},"available":true,"price":{"min":"51","max":"56"},"counters":null},{"id":147889,"title":"Тимолол-Акос","subtitle":{"full":"Капли, флакон, 1 шт, 5 мл, 0.5 %, глазные","short":"Капли, 1 шт, 5 мл, 0.5 %","package":"1 шт, 5 мл, 0.5 %"},"prescription":true,"catalog_section_id":53,"manufacturer":{"id":823,"title":"Синтез","slug":"sintez_ako_823","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Капли","slug":"147889-timololakos","attributes":{"count":"1 шт","dose":"0.5 %","volume":"5 мл","spf":"","size":""},"image":{"isTouch":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/55687/phoneMedium_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/55687/phoneMedium_default/"},"isFromTablet":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/55687/tabletLarge_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/55687/tabletLarge_default/"}},"image_thumb":{"isTouch":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/55687/previewTouch_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/55687/previewTouch_default/"},"isFromTablet":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/55687/previewDesktopMedium_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/55687/previewDesktopMedium_default/"}},"available":true,"price":{"min":"35","max":"35"},"counters":null},{"id":92567,"title":"Тимолол-мэз","subtitle":{"full":"Капли, флакон, 5 мл, 0,5 %, глазные","short":"Капли, 5 мл, 0,5 %","package":"5 мл, 0,5 %"},"prescription":true,"catalog_section_id":53,"manufacturer":{"id":4306,"title":"Моск.Эндокринн. 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