Профилактика и раннее лечение гриппа у взрослых и детей старше 7 лет, профилактика гриппа в период эпидемий у взрослых, профилактика клещевого энцефалита вирусной этиологии.
Противопоказания
Острые заболевания печени, острые и хронические заболевания почек, тиреотоксикоз, беременность, детский возраст до 7 лет, повышенная чувствительность к римантадину.
Противовирусное средство, производное адамантана. Основной механизм противовирусного действия - ингибирование ранней стадии специфической репродукции после проникновения вируса в клетку и до начальной транскрипции РНК. Фармакологическая эффективность обеспечивается при ингибировании репродукции вируса в начальной стадии инфекционного процесса. Активен в отношении различных штаммов вируса гриппа A (особенно A2 типа), а также - вирусов клещевого энцефалита (центрально-европейского и российского весенне-летнего), которые принадлежат к группе арбовирусов семейства Flaviviridae.
Показания к применению
Профилактика и раннее лечение гриппа у взрослых и детей старше 7 лет, профилактика гриппа в период эпидемий у взрослых, профилактика клещевого энцефалита вирусной этиологии.
Противопоказания
Острые заболевания печени, острые и хронические заболевания почек, тиреотоксикоз, беременность, детский возраст до 7 лет, повышенная чувствительность к римантадину.
Применение при беременности и в период грудного вскармливания
Противопоказан при беременности.
Способ применения и дозы
Индивидуальный, в зависимости от показаний, возраста пациента и применяемой схемы лечения.
Побочное действие
Со стороны пищеварительной системы: боли в эпигастрии, метеоризм, повышение уровня билирубина в крови, сухость во рту, анорексия, тошнота, рвота, гастралгия. Со стороны ЦНС: головная боль, бессонница, нервозность, головокружение, нарушение концентрации внимания, сонливость, тревожность, повышенная возбудимость, усталость. Прочие: аллергические реакции.
Передозировка
Симптомы: возбуждение, галлюцинации, аритмия. Лечение: промывание желудка, симптоматическая терапия: мероприятия для поддержания жизненно важных функций. Римантадин частично выводится при гемодиализе.
Особые указания
С осторожностью применяют римантадин при артериальной гипертензии, эпилепсии (в т.ч. в анамнезе), атеросклерозе сосудов головного мозга. При применении римантадина возможно обострение хронических сопутствующих заболеваний. У пациентов пожилого возраста с артериальной гипертензией повышается риск развития геморрагического инсульта. При указаниях в анамнезе на эпилепсию и проводившуюся противосудорожную терапию, на фоне применения римантадина повышается риск развития эпилептического припадка. В таких случаях римантадин применяют в дозе до 100 мг/сут одновременно с противосудорожной терапией. При гриппе, вызванном вирусом B, римантадин оказывает антитоксическое действие. Профилактический прием эффективен при контактах с заболевшими, при распространении инфекции в замкнутых коллективах и при высоком риске возникновения заболевания во время эпидемии гриппа. Возможно появление резистентных к препарату вирусов.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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