Викейра Пак Таблетки, 112 шт, 12,5+75+50 мг, набор таблеток

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AUC)."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"— хронический гепатит С генотипа 1, включая пациентов с компенсированным циррозом печени, в сочетании с рибавирином или без него."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Гиперчувствительность к омбитасвиру, паритапревиру, ритонавиру, дасабувиру или любым вспомогательным веществам препарата (например, токсический эпидермальный некролиз или синдром Стивенса-Джонсона)","Средняя и тяжелая степень печеночной недостаточности (классы B и С по Чайлд-Пью)","Противопоказания к применению рибавирина (при совместном применении препарата Викейра Пак и рибавирина). Для получения информации о противопоказаниях к применению рибавирина необходимо ознакомиться с его инструкцией по применению","Применение рибавирина у женщин во время беременности, а также у мужчин, чьи партнерши беременны","Одновременное применение препаратов, повышение концентрации которых и плазме крови может принести к серьезным побочным реакциям и клиренс которых значительно зависит от метаболизма посредством изофермента CYP3A","Одновременное применение препаратов, являющихся мощными ингибиторами CYP2C8 (т.к. это может привести к существенному повышению концентрации дасабувира в плазме крови и риску удлинения интервала QТ)","Одновременное применение препаратов - мощных и умеренных индукторов изофермента CYP3A (может существенно снижать концентрации паритапревира, омбитасвира и дасабувира в плазме крови)","Одновременное применение препаратов, являющихся мощными индукторами изофермента CYP2C8 (т.к. это может привести к существенному снижению концентрации дасабувира в плазме крови)","Одновременное применение с препаратами, содержащими этинилэстрадиол (например, комбинированные пероральные контрацептивы)","Одновременное применение с препаратами: -субстраты изофермента CYP3A4 - алфузозин; амиодарон; астемизол, терфенадин; колхицин (у пациентов с почечной и/или печеночной недостаточностью); алкалоиды спорыньи (эрготамин, дигидроэрготамин, эргометрин, метилэргометрин); фузидовая кислота; ловастатин, симвастатин, аторвастатин; мидазолам и триазолам (в лекарственных формах для приема внутрь); пимозид; кветиапин; хинидин; салметерол; силденафил (при использовании для лечения легочной артериальной гипертензии); тикагрелор; цизаприд; -индукторы изофермента CYP3A4 - карбамазепин, фенитоин, фенобарбитал; эфавиренз; невирапин; этравирин; энзалутамид; митотан; рифампицин; препараты зверобоя (зверобой продырявленный /Hypericum perforatum/); -ингибиторы изофермента CYP3A4 - кобицистат; индинавир, лопинавир/ритонавир; сквинавир; типранавир; итраконазол, кетоконазол, позаконазол, вориконазол; кларитромицин, телитромицин; кониваптан; -ингибиторы изофермента CYP2C8 - гемфиброзил; -препараты, метаболизирующиеся изоферментом CYP3A4 - рилпивирин; -препараты для лечения ВИЧ, ингибиторы протеазы - дарунавир/ритонавир; атазанавир/ритонавир в фиксированной комбинации","Детский возраст до 18 лет","Дефицит лактазы, непереносимость галактозы, глюкозо-галактозная мальабсорбция. С осторожностьюСовместное применение препарата Викейра Пак и флутиказона или других ГКС, которые метаболизируются с участием изофермента CYP3A4. Совместное применение с антиаритмическими препаратами, а также со следующими препаратами: бепридил, дизопирамид, флекаинид, лидокаин (системное введение), мексилетин, пропафенон, эритромицин, дабигатран, дилтиазем, флувастатин, репаглинид, сульфасалазин, тразодон, фексофенадин, деферазирокс, терифлуномид"]}}]},{"id":5,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь. Препарат Викейра Пак следует принимать во время еды, независимо от жирности или калорийности пищи. Перед началом терапии препаратом Викейра Пак необходимо исключить декомпенсацию функции печени на основании лабораторных и клинических признаков. Рекомендуемая доза препарата Викейра Пак включает 2 таб. омбитасвира/паритапревира/ритонавира 12.5/75/50 мг 1 раз/сут (утром) и 1 таб. дасабувира 250 мг 2 раза/сут (утром и вечером). При применении с препаратом Викейра Пак, рекомендуемая доза рибавирина основывается на массе тела пациента: 1000 мг/сут для пациентов с массой тела ≤75 кг и 1200 мг/сут для пациентов с массой тела \u003e75 кг, разделенная на 2 приема в день с едой. При необходимости коррекции дозы рибавирина рекомендуется ознакомиться с его инструкцией по применению. Препарат Викейра Пак следует принимать в соответствии с продолжительностью, рекомендованной и инструкции по его применению, без перерыва или изменения дозы препарата. Если препарат Викейра Пак применяется совместно с рибавирином, то рибавирин следует назначать на тот же срок, что и препарат Викейра Пак. Пропуск приема препаратаВ случае пропуска приема таблетки, содержащей омбитасвир + паритапревир + ритонавир, назначенная доза может быть принята в течение 12 ч после запланированного времени. В случае пропуска приема таблетки, содержащей дасабувир, назначенная доза может быть принята в течение 6 часов после запланированного времени. В случае, если прошло более 12 ч с запланированного времени приема таблетки, содержащей омбитасвир + паритапревир + ритонавир или более 6 ч после запланированного времени приема таблетки, содержащей дасабувир, пропущенные дозы не принимаются и пациент должен принять следующую дозу согласно обычному графику приема препарата. Особые группы пациентовРекомендуемая продолжительность лечения пациентов с нормальной функцией печени и стадией фиброза по шкале Metavir-2 и менее после трансплантации печени с применением препарата Викейра Пак в комбинации с рибавирином составляет 24 недели, независимо от генотипа ВГС 1 подтипа. При применении препарата Викейра Пак с ингибиторами кальциневрина необходима коррекция дозы ингибиторов кальциневрина. В клинических исследованиях у пациентов после трансплантации печени были индивидуально подобраны дозы рибавирина, которые составляли от 600 мг до 800 мг в сутки. Рекомендации по сопутствующей противовирусной терапии ВИЧ-1 представлены в разделе Лекарственное взаимодействие. У пациентов с легкой степенью печеночной недостаточности (класс А по шкале Чайлд-Пью) коррекции дозы препарата Викейра Пак не требуется. Препарат Викейра Пак противопоказан у пациентов со средней и тяжелой формой печеночной недостаточности (класс В и С по шкале Чайлд-Пью). Следует проводить контроль показателей функции печени в течение первых 4 недель терапии. У пациентов с почечной недостаточностью легкой, средней, тяжелой степени тяжести, а также у пациентов с терминальной стадией почечной недостаточности (4–5 степень), находящихся на диализе, коррекция дозы не требуется. В случае необходимости включения в схему рибавирина, следует ознакомиться с инструкцией по применению рибавирина. Данные по эффективности и безопасности у детей младше 18 лет отсутствуют. Коррекция дозы у пациентов пожилого возраста не требуется. В III стадии клинических исследований генотипа 1 участвовал только один пациент старше 65 лет. Не наблюдалось отличий в эффективности и безопасности терапии у молодых пациентов и пациентов пожилого возраста."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":" Набор таблеток."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Максимальная допустимая температура хранения, °С\t25 °C."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"24 месяца."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЭббВи Айрлэнд НЛ Б.В. (Ирландия)."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Комбинированный противовирусный препарат. Препарат Викейра Пак сочетает в себе три противовирусных вещества прямого действия для лечения вирусного гепатита С (ВГС) с различными механизмами действия и с непересекающимися профилями резистентности, что позволяет бороться с вирусом гепатита С на разных этапах его жизненного цикла, и ритонавир. Дасабувир является ненуклеозидным ингибитором РНК-зависимой РНК-полимеразы вируса, кодируемой геном NS5B, которая необходима для репликации вирусного генома. Согласно биохимическим исследованиям, дасабувир ингибирует полимеразную активность NS5B ферментов рекомбинантного генотипа 1а и 1b ВГС со значениями IС30 2.8 и 10.7 нМ соответственно. Омбитасвир является ингибитором белка NS5A ВГС, необходимого для репликации вируса. В исследованиях на репликонных клеточных культурах значения EC50 для омбитасвира составляли 14.1 и 5.0 нМ для генотипов Iа и Ib ВГС соответственно. Паритапревир является ингибитором протеазы ВГС NS3/4A, которая необходима для протеолитического расщепления кодированного полипротеина ВГС (в зрелые формы белков NS3, NS4A, NS4B, NS5A и NS5B) и имеет важное значение для репликации вируса. Согласно биохимическому анализу, паритапревир ингибирует протеолитическую активность протеазы NS3/4A рекомбинантного генотипа ВГС 1а и 1b со значениями IС50 0.18 и 0.43 нМ соответственно. Ритонавир не обладает противовирусной активностью в отношении ВГС. Ритонавир выступает как фармакокинетический усилитель, который увеличивает Cmax паритапревира в плазме крови и концентрацию паритапревира, измеряемую непосредственно перед приемом его очередной дозы, и увеличивает общую экспозицию препарата (т.е. AUC).","substance":[{"id":2329,"title":"Ритонавир","title_latin":"ritonavir","slug":"ritonavir"},{"id":2330,"title":"Паритапревир","title_latin":"paritaprevir","slug":"paritaprevir"},{"id":2331,"title":"Омбитасвир","title_latin":"ombitasvir","slug":"ombitasvir"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Викейра Пак - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/5044/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/5044/share_default/"}},"diseases":[{"id":"111","title":"Хронический вирусный гепатит С","slug":"111-hronicheskiy_virusnyy_gepatit_s"}],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"nondrugs","products":[{"id":99847,"title":"Алпизарин","subtitle":{"full":"Таблетки, 20 шт, 100 мг","short":"Таблетки, 20 шт, 100 мг","package":"20 шт, 100 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