Вспомогательная терапия при установленных хронических заболеваниях печени, для улучшения и поддержания ее функций. Повышенная утомляемость при установленных хронических заболеваниях печени.
Противопоказания
Генетические нарушения,
влияющие на метиониновый цикл, и/или вызывающие гомоцистинурию и/или
гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма
витамина В12).
Гиперчувствительность к адеметионину
и/или к любому из вспомогательных веществ в составе препарата.
Таблетки овальной формы, двояковыпуклые, гладкие, от белого до
светло-желтого цвета, покрытые пленочной оболочкой.
Фармакотерапевтическая группа
Прочие препараты для желудочно-кишечного тракта и
обмена веществ, аминокислоты и их производные.
Фармакологические свойства
Фармакодинамика
Адеметионин
относится к группе гепатопротекторов. Оказывает желчегонное действие, обладает
детоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и
нейропротективными свойствами.
Адеметионин (S-аденозил-L-метионин) –
это аминокислота естественного происхождения, которая присутствует практически
во всех тканях и биологических жидкостях в организме. Наибольшая
концентрация адеметионина отмечена в печени и мозге. Адеметионин является производным серосодержащей
аминокислоты – метионина. Выполняет ключевую
роль в метаболических процессах организма, принимает участие в важных
биохимических реакциях. Участвует в синтезе фосфолипидов клеточных мембран,
нейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. Адеметионин является
предшественником цистеина, таурина,
глутатиона (обеспечивая окислительно-восстановительный механизм
клеточной детоксикации), коэнзима А (включается в биохимические реакции цикла
трикарбоновых кислот и восполняет энергетический потенциал клетки). Повышает
содержание глутамина в печени, цистеина и таурина в плазме; снижает содержание
метионина в сыворотке, нормализуя метаболические реакции в печени. Опосредованно участвует в стимуляции регенерации и
пролиферации клеток печени, что уменьшает риск фиброзирования.
Адеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что
повышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных
с мембранами гепатоцитов транспортных систем желчных кислот и способствует
пассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом
варианте холестаза (нарушение синтеза и тока желчи). Адеметионин
снижает токсичность желчных кислот в клетках печени. У пациентов с
диффузными заболеваниями печени (цирроз, гепатит) адеметионин снижает
выраженность кожного зуда и способствует улучшению биохимических показателей
крови, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы,
аминотрансфераз и др. Желчегонный и гепатопротекторный эффект сохраняется до 3
месяцев после прекращения лечения. Показана эффективность при гепатопатиях, обусловленных различными гепатотоксичными
препаратами. В ряде исследований была
подтверждена эффективность адеметионина при лечении повышенной утомляемости у
пациентов с хроническими заболеваниями печени.
Фармакокинетика
Таблетки
покрыты пленочной оболочкой, растворяющейся только в кишечнике, благодаря чему
адеметионин высвобождается в двенадцатиперстной кишке.
Всасывание
Максимальные
концентрации (Cmax) адеметионина в плазме являются дозозависимыми и
составляют 0,5-1 мг/л через 3-5 часов после однократного приема внутрь в дозах
от 400 до 1000 мг. Cmax адеметионина в плазме снижаются до исходного
уровня в течение 24 часов. Биодоступность адеметионина при пероральном приеме
увеличивается при приеме препарата натощак.
Распределение
Связь с белками плазмы крови – незначительная, составляет ≤
5 %. Проникает через гематоэнцефалический барьер. Отмечается значительное
увеличение концентрации адеметионина в спинномозговой жидкости.
Метаболизм
Метаболизируется в печени. Процесс образования,
расходования и повторного образования адеметионина называется циклом
адеметионина. На первом этапе этого цикла адеметионинзависимые метилазы
используют адеметионин в качестве субстрата для продукции S-аденозилгомоцистеина,
который затем гидролизуется до гомоцистеина и аденозина с помощью S-аденозилгомоцистеингидролазы.
Гомоцистеин, в свою очередь, подвергается обратной трансформации до метионина
путем переноса метильной группы от 5-метилтетрагидрофолата. В итоге метионин
может быть преобразован в адеметионин, завершая цикл.
Выведение
Период полувыведения (T1/2) – 1,5 ч. Выводится
почками. В исследованиях у здоровых добровольцев при приеме внутрь меченного
(метил 14C) S‑aденозил-L-метионина в моче было обнаружено 15,5 ± 1,5 %
радиоактивности через 48 часов, a в кале – 23,5 ± 3,5 % радиоактивности через
72 часа. Таким образом, около 60 % было задепонировано.
Показания к применению
Вспомогательная терапия при установленных хронических заболеваниях печени, для улучшения и поддержания ее функций. Повышенная утомляемость при установленных хронических заболеваниях печени.
Противопоказания
Генетические нарушения,
влияющие на метиониновый цикл, и/или вызывающие гомоцистинурию и/или
гипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма
витамина В12).
Гиперчувствительность к адеметионину
и/или к любому из вспомогательных веществ в составе препарата.
Возраст
до 18 лет (в связи с отсутствием данных по эффективности и безопасности применения
адеметионина в данной возрастной популяции).
Биполярные расстройства.
Если у Вас есть одно из перечисленных выше заболеваний/состояний или
факторов риска, перед применением препарата необходимо проконсультироваться с
врачом.
С осторожностью
Одновременный прием с
селективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими
антидепрессантами (такими как кломипрамин), а также лекарственными средствами,
содержащими триптофан, в том числе, растительного происхождения (см. раздел
«Взаимодействие с другими лекарственными средствами»).
Пожилой возраст.
Почечная недостаточность.
Если у Вас есть одно из перечисленных выше заболеваний/состояний или
факторов риска, перед применением препарата необходимо проконсультироваться с
врачом.
Применение при беременности и в период грудного вскармливания
Применение препарата Гептрал при беременности и в период грудного вскармливания не рекомендуется без наблюдения у врача.
Способ применения и дозы
Внутрь.
Таблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи.
Таблетки препарата Гептрал следует вынимать из блистера непосредственно перед приемом внутрь. В случае если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком (вследствие негерметичности алюминиевой фольги), препарат Гептрал применять не рекомендуется.
Рекомендуемая доза составляет 10-25 мг адеметионина на 1 кг массы тела в сутки. Обычно суточная доза составляет 1-2 таблетки в сутки (от 400-800 мг адеметионина в сутки) и может быть увеличена до 4 таблеток в сутки (до 1600 мг адеметионина в сутки). Эффект обычно проявляется через 7-14 дней лечения и сохраняется при дальнейшем применении препарата.
При отсутствии положительного эффекта от проводимой в течение 2 недель терапии препаратом или ухудшении состояния следует обратиться к врачу.
Перечень всех побочных действий представлен в инструкции по медицинскому применению.
Передозировка
Передозировка препаратом Гептрал маловероятна. В случае передозировки препарата Гептрал следует немедленно обратиться к врачу. Лечение: симптоматическое.
Взаимодействие с другими лекарственными средствами
Известных взаимодействий с другими лекарственными средствами не наблюдалось. Следует с осторожностью применять адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан (в том числе, растительного происхождения).
Особые указания
Необходимо обратиться к врачу при отсутствии улучшения или ухудшении состояния. Учитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном. Пациентам с депрессией или получающих антидепрессанты следует обратиться к врачу перед началом приема препарата Гептрал. Имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев прекращения приема препарата не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата.
Поскольку дефицит цианокобаламина (витамина В12) и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием витаминов (цианокобаламина и фолиевой кислоты) до начала лечения адеметионином или одновременный прием с адеметионином.
Влияние на способность управлять автомобилем и движущимися механизмами
При применении препарата Гептралвозможны головокружение и снижение артериального давления. В случае появления данных нежелательных реакций следует воздержаться от управления транспортными средствами и механизмами до их исчезновения.
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номер","slug":"","body":[{"type":"paragraph","data":{"text":"П N011968/01"}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Гептрал"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые кишечнорастворимой\nоболочкой."}}]},{"id":1,"name":"Состав","slug":"ingredients","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Каждая\nтаблетка содержит:"}},{"type":"paragraph","data":{"text":"Действующее\nвещество: адеметионина\n1,4-бутандисульфонат 760 мг (эквивалентно 400 мг иона адеметионина)."}},{"type":"paragraph","data":{"text":"Вспомогательные\nвещества: кремния диоксид коллоидный – 4,40\nмг, целлюлоза микрокристаллическая – 93,60 мг, карбоксиметилкрахмал натрия (тип\nА) – 17,60 мг, магния стеарат – 4,4 мг; \u003ci\u003eоболочка таблетки\u003c/i\u003e: метакриловой кислоты\nи этилакрилата сополимер (1:1) – 27,60 мг, макрогол-6000 – 8,07 мг,\nполисорбат-80 – 0,44 мг, симетикон эмульсия (30 %) – 0,13 мг, натрия\nгидроксид – 0,36 мг, тальк – 18,40 мг, вода – Q.S."}}]},{"id":6,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Таблетки овальной формы, двояковыпуклые, гладкие, от белого до\nсветло-желтого цвета, покрытые пленочной оболочкой."}}]},{"id":14,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Прочие препараты для желудочно-кишечного тракта и\nобмена веществ, аминокислоты и их производные."}}]},{"id":15,"name":"Фармакологические свойства","slug":"","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакодинамика\n\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Адеметионин\nотносится к группе гепатопротекторов. Оказывает желчегонное действие, обладает\nдетоксикационными, регенерирующими, антиоксидантными, антифиброзирующими и\nнейропротективными свойствами."}},{"type":"paragraph","data":{"text":"Адеметионин (S-аденозил-L-метионин) –\nэто аминокислота естественного происхождения, которая присутствует практически\nво всех тканях и биологических жидкостях в организме. Наибольшая\nконцентрация адеметионина отмечена в печени и мозге. Адеметионин является производным серосодержащей\nаминокислоты – метионина. Выполняет ключевую\nроль в метаболических процессах организма, принимает участие в важных\nбиохимических реакциях. Участвует в синтезе фосфолипидов клеточных мембран,\nнейротрансмиттеров, нуклеиновых кислот, белков, гормонов и др. Адеметионин является\nпредшественником цистеина, таурина,\nглутатиона (обеспечивая окислительно-восстановительный механизм\nклеточной детоксикации), коэнзима А (включается в биохимические реакции цикла\nтрикарбоновых кислот и восполняет энергетический потенциал клетки). Повышает\nсодержание глутамина в печени, цистеина и таурина в плазме; снижает содержание\nметионина в сыворотке, нормализуя метаболические реакции в печени. Опосредованно участвует в стимуляции регенерации и\nпролиферации клеток печени, что уменьшает риск фиброзирования.\nАдеметионин нормализует синтез эндогенного фосфатидилхолина в гепатоцитах, что\nповышает текучесть и поляризацию мембран. Это улучшает функцию ассоциированных\nс мембранами гепатоцитов транспортных систем желчных кислот и способствует\nпассажу желчных кислот в желчевыводящие пути. Эффективен при внутридольковом\nварианте холестаза (нарушение синтеза и тока желчи). Адеметионин\nснижает токсичность желчных кислот в клетках печени. У пациентов с\nдиффузными заболеваниями печени (цирроз, гепатит) адеметионин снижает\nвыраженность кожного зуда и способствует улучшению биохимических показателей\nкрови, в т.ч. концентрации прямого билирубина, активности щелочной фосфатазы,\nаминотрансфераз и др. Желчегонный и гепатопротекторный эффект сохраняется до 3\nмесяцев после прекращения лечения. Показана эффективность при гепатопатиях, обусловленных различными гепатотоксичными\nпрепаратами. В ряде исследований была\nподтверждена эффективность адеметионина при лечении повышенной утомляемости у\nпациентов с хроническими заболеваниями печени."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Таблетки\nпокрыты пленочной оболочкой, растворяющейся только в кишечнике, благодаря чему\nадеметионин высвобождается в двенадцатиперстной кишке."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВсасывание\n\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Максимальные\nконцентрации (C\u003csub\u003emax\u003c/sub\u003e) адеметионина в плазме являются дозозависимыми и\nсоставляют 0,5-1 мг/л через 3-5 часов после однократного приема внутрь в дозах\nот 400 до 1000 мг. C\u003csub\u003emax\u003c/sub\u003e адеметионина в плазме снижаются до исходного\nуровня в течение 24 часов. Биодоступность адеметионина при пероральном приеме\nувеличивается при приеме препарата натощак."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\n\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Связь с белками плазмы крови – незначительная, составляет ≤\n5 %. Проникает через гематоэнцефалический барьер. Отмечается значительное\nувеличение концентрации адеметионина в спинномозговой жидкости."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Метаболизируется в печени. Процесс образования,\nрасходования и повторного образования адеметионина называется циклом\nадеметионина. На первом этапе этого цикла адеметионинзависимые метилазы\nиспользуют адеметионин в качестве субстрата для продукции S-аденозилгомоцистеина,\nкоторый затем гидролизуется до гомоцистеина и аденозина с помощью S-аденозилгомоцистеингидролазы.\nГомоцистеин, в свою очередь, подвергается обратной трансформации до метионина\nпутем переноса метильной группы от 5-метилтетрагидрофолата. В итоге метионин\nможет быть преобразован в адеметионин, завершая цикл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Период полувыведения (T\u003csub\u003e1/2\u003c/sub\u003e) – 1,5 ч. Выводится\nпочками. В исследованиях у здоровых добровольцев при приеме внутрь меченного\n(метил 14C) S‑aденозил-L-метионина в моче было обнаружено 15,5 ± 1,5 %\nрадиоактивности через 48 часов, a в кале – 23,5 ± 3,5 % радиоактивности через\n72 часа. Таким образом, около 60 % было задепонировано."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Вспомогательная терапия при установленных хронических заболеваниях печени, для улучшения и поддержания ее функций. Повышенная утомляемость при установленных хронических заболеваниях печени."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Генетические нарушения,\nвлияющие на метиониновый цикл, и/или вызывающие гомоцистинурию и/или\nгипергомоцистеинемию (дефицит цистатионин бетасинтазы, нарушение метаболизма\nвитамина В\u003csub\u003e12\u003c/sub\u003e)."}},{"type":"paragraph","data":{"text":"Гиперчувствительность к адеметионину\nи/или к любому из вспомогательных веществ в составе препарата."}},{"type":"paragraph","data":{"text":"Возраст\nдо 18 лет (в связи с отсутствием данных по эффективности и безопасности применения\nадеметионина в данной возрастной популяции)."}},{"type":"paragraph","data":{"text":"Биполярные расстройства."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас есть одно из перечисленных выше заболеваний/состояний или\nфакторов риска, перед применением препарата необходимо проконсультироваться с\nврачом.\u003c/i\u003e"}}]},{"id":16,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Одновременный прием с\nселективными ингибиторами обратного захвата серотонина (СИОЗС), трициклическими\nантидепрессантами (такими как кломипрамин), а также лекарственными средствами,\nсодержащими триптофан, в том числе, растительного происхождения (см. раздел\n«Взаимодействие с другими лекарственными средствами»)."}},{"type":"paragraph","data":{"text":"Пожилой возраст."}},{"type":"paragraph","data":{"text":"Почечная недостаточность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас есть одно из перечисленных выше заболеваний/состояний или\nфакторов риска, перед применением препарата необходимо проконсультироваться с\nврачом.\u003c/i\u003e"}}]},{"id":17,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата Гептрал при беременности и в период грудного вскармливания не рекомендуется без наблюдения у врача."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"Таблетки следует принимать целиком, не разжевывая, желательно в первой половине дня между приемами пищи."}},{"type":"paragraph","data":{"text":"Таблетки препарата Гептрал следует вынимать из блистера непосредственно перед приемом внутрь. В случае если таблетки имеют цвет, отличный от белого до белого с желтоватым оттенком (вследствие негерметичности алюминиевой фольги), препарат Гептрал применять не рекомендуется."}},{"type":"paragraph","data":{"text":"Рекомендуемая доза составляет 10-25 мг адеметионина на 1 кг массы тела в сутки. Обычно суточная доза составляет 1-2 таблетки в сутки (от 400-800 мг адеметионина в сутки) и может быть увеличена до 4 таблеток в сутки (до 1600 мг адеметионина в сутки). Эффект обычно проявляется через 7-14 дней лечения и сохраняется при дальнейшем применении препарата."}},{"type":"paragraph","data":{"text":"При отсутствии положительного эффекта от проводимой в течение 2 недель терапии препаратом или ухудшении состояния следует обратиться к врачу."}}]},{"name":"Побочное действие","slug":"side_effects","id":18,"body":[{"type":"paragraph","data":{"text":"Тревога, бессонница, головная боль, боль в животе, диарея, тошнота, кожный зуд, астения."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПеречень всех побочных действий представлен в инструкции по медицинскому применению. \u003c/i\u003e\u003c/b\u003e"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Передозировка препаратом Гептрал маловероятна. В случае передозировки препарата Гептрал следует немедленно обратиться к врачу. Лечение: симптоматическое."}}]},{"id":9,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Известных взаимодействий с другими лекарственными средствами не наблюдалось. Следует с осторожностью применять адеметионин вместе с селективными ингибиторами обратного захвата серотонина, трициклическими антидепрессантами (такими как кломипрамин), а также лекарственными средствами, содержащими триптофан (в том числе, растительного происхождения)."}}]},{"id":10,"name":"Особые указания","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Необходимо обратиться к врачу при отсутствии улучшения или ухудшении состояния. Учитывая тонизирующий эффект препарата, не рекомендуется принимать его перед сном. Пациентам с депрессией или получающих антидепрессанты следует обратиться к врачу перед началом приема препарата Гептрал. Имеются сообщения о внезапном появлении или нарастании тревоги у пациентов, принимающих адеметионин. В большинстве случаев прекращения приема препарата не требуется, в нескольких случаях тревога исчезала после снижения дозы или отмены препарата."}},{"type":"paragraph","data":{"text":"Поскольку дефицит цианокобаламина (витамина В\u003csub\u003e12\u003c/sub\u003e) и фолиевой кислоты может снизить содержание адеметионина у пациентов группы риска (с анемией, заболеваниями печени, при беременности или вероятностью витаминной недостаточности, в связи с другими заболеваниями или диетой, например, у вегетарианцев), следует контролировать содержание витаминов в плазме крови. Если недостаточность обнаружена, рекомендован прием витаминов (цианокобаламина и фолиевой кислоты) до начала лечения адеметионином или одновременный прием с адеметионином."}}],"slug":""},{"id":19,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"При применении препарата Гептрал\u003csup\u003e \u003c/sup\u003eвозможны головокружение и снижение артериального давления. В случае появления данных нежелательных реакций следует воздержаться от управления транспортными средствами и механизмами до их исчезновения."}}]},{"id":20,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки,\nпокрытые кишечнорастворимой оболочкой, 400 мг."}},{"type":"paragraph","data":{"text":"По 10\nтаблеток в ALU/ALU блистер. 1 или 2 блистера вместе с\nинструкцией по применению помещают в картонную пачку."}}]},{"id":11,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Хранить в защищенном от света месте при температуре от 15 °С до 25 °С.\u003cbr /\u003e\nХранить в недоступном для детей месте."}}]},{"id":12,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"3 года. Не применять препарат по истечении срока годности."}}]},{"id":13,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Без рецепта.\u003cbr\u003e"}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЭббВи С.р.Л., Италия"}},{"type":"paragraph","data":{"text":"Cтрада Реджионале. 148,\nПонтина км. 52, СНК-Камповерде ди Априлиа (Априлиа), 04011 Априлиа (Латина), \u003ca\u003eИталия\u003c/a\u003e"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Эбботт Лэбораториз»"}},{"type":"paragraph","data":{"text":"125171, г. Москва, Ленинградское шоссе, дом\n16А, стр. 1"}},{"type":"paragraph","data":{"text":"Тел.: +7 (495) 258 42 80"}},{"type":"paragraph","data":{"text":"Факс: +7 (495) 258 42 81"}},{"type":"paragraph","data":{"text":"\u003ca href=\"mailto:abbott-russia@abbott.com\"\u003eabbott-russia@abbott.com\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Таблетки овальной формы, двояковыпуклые, гладкие, от белого до светло-желтого цвета, покрытые пленочной оболочкой.","substance":[{"id":504,"title":"Адеметионин","title_latin":"Adamethioninum","slug":"ademetionin_504"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":{"count":98,"url":"/review/2338-heptral/"},"image_alt":"Гептрал - фото 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