Изотретиноин представляет собой одну из биологически активны... Инструкция
Показания к применению
У взрослых и подростков старше 12 лет папуло-пустулезная и комедональная формы угрей обыкновенных, розацеа (при небольшом количестве высыпаний), периоральный дерматит, нерезко выраженный себорейный дерматит. После отмены ретиноидов, применявшихся внутрь или ректально, возможно использование препарата Ретасол с целью поддержания достигнутого клинического эффекта.
Противопоказания
повышенная индивидуальная чувствительность к препарату или его компонентам;
прозрачная маслянистая жидкость от светло-жёлтого до жёлтого цвета со слабым специфическим запахом этанола.
Фармакотерапевтическая группа
средство лечения угревой сыпи.
Фармакологические свойства
Изотретиноин представляет собой одну из биологически активных форм витамина А. Он тормозит терминальную дифференцировку себоцитов, гиперпролиферацию эпителия выводных протоков сальных желез, нормализует состав их секрета и облегчает его эвакуацию. За счет этого уменьшается выработка кожного сала, облегчается его выделение, нормализуется состав, снижается воспалительная реакция вокруг желез. Раствор оказывает антисеборейное, противовоспалительное, кератолитическое действие; усиливает процессы регенерации в коже.
Показания к применению
У взрослых и подростков старше 12 лет папуло-пустулезная и комедональная формы угрей обыкновенных, розацеа (при небольшом количестве высыпаний), периоральный дерматит, нерезко выраженный себорейный дерматит. После отмены ретиноидов, применявшихся внутрь или ректально, возможно использование препарата Ретасол с целью поддержания достигнутого клинического эффекта.
Противопоказания
повышенная индивидуальная чувствительность к препарату или его компонентам;
детский возраст до 12 лет;
беременность;
период грудного вскармливания;
сопутствующая терапия тетрациклинами;
гипервитаминоз А;
выраженная гиперлипидемия.
С осторожностью
При хронических заболеваниях печени, почек, хроническом панкреатите, декомпенсации сердечной деятельности, нарушении липидного обмена, алкоголизме.
Применение при беременности и в период грудного вскармливания
Противопоказан во время беременности, кормлении грудью и женщинам, планирующим беременность.
Беременность является абсолютным противопоказанием применения препарата. Изотретиноин относится к препаратам с сильным тератогенным действием. Если беременность возникает, несмотря на предостережения, во время лечения или в течении месяца после окончания терапии, существует большая опасность рождение ребёнка с тяжёлыми пороками развития. При возникновении беременности лечение изотретиноином прекращают. Следует обсудить целесообразность сохранения беременности с врачом, специализирующимся по тератологии. Использование противозачаточных средств во время лечения изотретиноином следует рекомендовать даже тем женщинам, которые обычно не применяют разного рода контрацепцию из-за бесплодия, аменореи или которые сообщают, что не ведут половую жизнь.
Поскольку изотретиноин обладает высокой липофильностью, он может попасть в грудное молоко. Назначение изотретиноина кормящим матерям противопоказано.
Способ применения и дозы
Раствор наносят ватным тампоном на предварительно очищенную кожу (после умывания или протирания тоником, не содержащим алкоголя) 2 раза в день. Продолжительность лечения – 4 - 12 недель. Повторный курс лечения возможен после консультации с врачом.
Побочное действие
На первой неделе лечения возможно реакции обострения – появление новых высыпаний, зуда, отечности, покраснения и шелушения кожи. При резко выраженной реакции рекомендуется прекратить лечение на несколько дней до её стихания. В отдельных случаях наблюдается непереносимость препарата – в первый - второй день применения появляются пятнисто-папулезные высыпания, зуд и отечность. В таких случаях следует отменить препарат и обратиться к врачу.
Передозировка
При длительном применении возможны явления передозировки: покраснение и шелушение кожи в местах нанесения препарата, хейлит. Явления передозировки быстро проходят после отмены препарата и применения глюкокортикостероидов.
Взаимодействие с другими лекарственными средствами
Раствор не следует назначать больным, получающим другие препараты из группы ретиноидов, чтобы уменьшить риск возникновения гипервитаминоза А. Действие раствора ослабляется при местном применении глюкокортикостероидов. Одновременное применение с препаратами, повышающими фоточувствительность (в т.ч. сульфонамидами, тетрациклинами, тиазидными диуретиками), увеличивает риск возникновения солнечных ожогов. Изотретиноин может ослабить эффективность препаратов прогестерона. Сочетанное применение с местными кератолитическими препаратами для лечения акне не рекомендуется из-за возможного усиления местного раздражения. Поскольку тетрациклины увеличивают риск повышения внутричерепного давления, одновременное применение с изотретиноином противопоказано.
Особые указания
Не рекомендуется наносить раствор Ретасола на кожу вокруг глаз, а также при выраженном остром воспалении. Нельзя наносить на слизистые оболочки.
В период лечения рекомендуется использовать увлажняющую мазь и крем для тела, бальзам для губ для уменьшения сухости кожи.
Следует избегать проведения глубокой химической дермоабразии и лечения лазером, у больных получающих препараты с изотретиноином, из-за возможности усиления рубцевания в атипичных местах и возникновения гипер- и гипопигментации. В ходе лечения, а также в течение 6 месяцев после него, нельзя проводить эпиляцию с помощью аппликаций из-за риска отслойки эпидермиса, развития рубцов и дерматита.
Во время лечения следует ограничить воздействие солнечной инсоляции и УФ-терапии. Не рекомендуется посещение солярия. При необходимости следует пользоваться солнцезащитным кремом с высоким защитным фактором.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Раствор для наружного применения.
По 10, 15, 20, 30 и 50 мл во флаконах тёмного стекла с винтовой горловиной и навинчиваемыми пластмассовыми крышками с контролем первого вскрытия или без него, в комплекте с уплотняющей прокладкой.
Каждый флакон с инструкцией по применению помещают в пачку из картона.
Условия хранения
В защищенном от света месте при температуре не выше 22 °С. Хранить в недоступном для детей месте.
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Он тормозит терминальную дифференцировку себоцитов, гиперпролиферацию эпителия выводных протоков сальных желез, нормализует состав их секрета и облегчает его эвакуацию. За счет этого уменьшается выработка кожного сала, облегчается его выделение, нормализуется состав, снижается воспалительная реакция вокруг желез. Раствор оказывает антисеборейное, противовоспалительное, кератолитическое действие; усиливает процессы регенерации в коже."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":" У взрослых и подростков старше 12 лет папуло-пустулезная и комедональная формы угрей обыкновенных, розацеа (при небольшом количестве высыпаний), периоральный дерматит, нерезко выраженный себорейный дерматит. После отмены ретиноидов, применявшихся внутрь или ректально, возможно использование препарата Ретасол с целью поддержания достигнутого клинического эффекта. "}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["повышенная индивидуальная чувствительность к препарату или его компонентам;","детский возраст до 12 лет;","беременность;","период грудного вскармливания;","сопутствующая терапия тетрациклинами;","гипервитаминоз А;","выраженная гиперлипидемия."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При хронических заболеваниях печени, почек, хроническом панкреатите, декомпенсации сердечной деятельности, нарушении липидного обмена, алкоголизме."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказан во время беременности, кормлении грудью и женщинам, планирующим беременность."}},{"type":"paragraph","data":{"text":"Беременность является абсолютным противопоказанием применения препарата. 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Назначение изотретиноина кормящим матерям противопоказано."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Раствор наносят ватным тампоном на предварительно очищенную кожу (после умывания или протирания тоником, не содержащим алкоголя) 2 раза в день. Продолжительность лечения – 4 - 12 недель. Повторный курс лечения возможен после консультации с врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"На первой неделе лечения возможно реакции обострения – появление новых высыпаний, зуда, отечности, покраснения и шелушения кожи. При резко выраженной реакции рекомендуется прекратить лечение на несколько дней до её стихания. В отдельных случаях наблюдается непереносимость препарата – в первый - второй день применения появляются пятнисто-папулезные высыпания, зуд и отечность. 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Нельзя наносить на слизистые оболочки."}},{"type":"paragraph","data":{"text":"В период лечения рекомендуется использовать увлажняющую мазь и крем для тела, бальзам для губ для уменьшения сухости кожи."}},{"type":"paragraph","data":{"text":"Следует избегать проведения глубокой химической дермоабразии и лечения лазером, у больных получающих препараты с изотретиноином, из-за возможности усиления рубцевания в атипичных местах и возникновения гипер- и гипопигментации. В ходе лечения, а также в течение 6 месяцев после него, нельзя проводить эпиляцию с помощью аппликаций из-за риска отслойки эпидермиса, развития рубцов и дерматита."}},{"type":"paragraph","data":{"text":"Во время лечения следует ограничить воздействие солнечной инсоляции и УФ-терапии. Не рекомендуется посещение солярия. 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