1 флакон
50 мл раствора для инфузий 12 мг/мл содержит
активное вещество: меглуминовую соль тиоктовой кислоты - 1167,70 мг (что
эквивалентно 600 мг тиоктовой кислоты); вспомогательные
вещества: макрогол 300 - 4000,00 мг, меглумин, вода для инъекций до 50 мл.
Описание
Прозрачный раствор светло-желтого или желтовато-зеленого цвета.
Фармакотерапевтическая группа
Метаболическое средство.
Фармакологические свойства
Фармакодинамика
Тиоктовая (альфа-липоевая) кислота –
эндогенный антиоксидант прямого (связывает свободные радикалы) и непрямого
действия (восстанавливает физиологическую концентрацию глутатиона, повышает
активность супероксиддисмутазы).
В качестве кофермента
митохондриальных мультиферментных комплексов участвует в реакциях
окислительного фосфорилирования пировиноградной кислоты (ПВК) и
альфа-кетокислот.
По биохимическому механизму действия близка
к витаминам группы B.
Тиоктовая кислота оказывает
антиоксидантное, нейротрофическое, гипогликемическое действие, улучшает
метаболизм липидов:
- связываясь с избыточным количеством
свободных кислородных радикалов, защищает клетки от повреждения продуктами
распада; при сахарном диабете уменьшает образование конечных продуктов
прогрессирующего гликирования белков в нервных клетках, уменьшает
эндоневральную гипоксию и ишемию, повышает концентрацию антиоксиданта
глутатиона, тем самым, ослабляя проявления полинейропатии в виде парестезии,
ощущения жжения, боли и онемения конечностей;
- участвует в регулировании
углеводного обмена (способствует снижению концентрации глюкозы в плазме крови и
увеличению концентрации гликогена в печени, снижает инсулинорезистентность
тканей);
- стимулирует метаболизм холестерина,
снижая его концентрацию в плазме крови; участвуя в метаболизме жиров, тиоктовая
кислота увеличивает биосинтез фосфолипидов, в частности фосфоинозитидов,
благодаря чему восстанавливается поврежденная структура клеточных мембран;
нормализуется энергетический обмен и проведение нервных импульсов.
Фармакокинетика
При внутривенном введении
время достижения максимальной концентрации – 10 – 11 мин, максимальная концентрация
составляет около 20 мкг/мл. Обладает эффектом «первого прохождения» через
печень. Образование метаболитов происходит в результате окисления боковой цепи
и конъюгирования. Общий плазменный клиренс – 10 - 15 мл/мин. Тиоктовая кислота и ее
метаболиты выводится почками (80 – 90 %), в небольшом количестве – в неизменном
виде. Период полувыведения составляет 25 мин.
Повышенная чувствительность к
тиоктовой кислоте или другим компонентам препарата.
Детский возраст до 18 лет.
Беременность и период грудного
вскармливания.
Перед приемом препарата обязательно проконсультируйтесь с врачом.
Применение при беременности и в период грудного вскармливания
Применение при беременности и в
период лактации противопоказано.
Способ применения и дозы
В начале терапии препарат
Тиогамма®, раствор для инфузий, вводят внутривенно в дозе 600 мг (1
флакон) в сутки в течение 2-4 недель. Флакон с препаратом вынимают из коробки и
немедленно накрывают прилагаемым светозащитным футляром, т.к. тиоктовая кислота
чувствительна к свету. Инфузию производят непосредственно из флакона, используя
устройство (систему) для внутривенного вливания инфузионных растворов. Вводят
медленно, около 1,7 мл/мин, в течение 30 мин.
Затем переходят на
поддерживающую терапию препаратом тиоктовой кислоты для перорального применения
в дозе 600 мг в сутки. Продолжительность курса терапии и необходимость его
повторения определяется лечащим врачом.
Побочное действие
Частота проявления неблагоприятных побочных
реакций приведена в соответствии с классификацией ВОЗ:
Очень часто: ≥ 1/10 назначений
Часто: ≥ 1/100 до ≤ 1/10 назначений
Не часто: ≥ 1/1000 до ≤ 1/100 назначений
Редко: ≥ 1/10000 до ≤ 1/1000 назначений
Очень редко: ≤ 1/ 10000 назначений
Частота неизвестна: невозможно установить из имеющихся
данных
Нарушения
со стороны крови и лимфатической системы:
очень редко: точечные кровоизлияния в
слизистые оболочки, кожу, тромбоцитопения, геморрагическая сыпь (пурпура),
тромбофлебит;
Нарушения со стороны иммунной
системы:
частота неизвестна: системные
аллергические реакции (вплоть до развития анафилактического шока);
частота неизвестна: аутоиммунный
инсулиновый синдром (АИС) у пациентов с сахарным диабетом, который
характеризуется частыми гипогликемиями в условиях наличия аутоантител к
инсулину.
Нарушения
со стороны нервной системы:
очень редко: изменение или нарушение
вкусовых ощущений;
очень редко: судороги;
Нарушения со стороны органа зрения:
очень редко: диплопия;
Нарушения со стороны кожи и подкожных
тканей:
частота неизвестна: аллергические
реакции - крапивница, зуд, экзема, сыпь.
Общие расстройства и нарушения в
месте введения:
частота неизвестна: в связи с
улучшением усвоения глюкозы возможно снижение концентрации глюкозы в крови. При
этом могут возникнуть симптомы гипогликемии – головокружение, повышенное
потоотделение, головная боль, расстройства зрения;
очень редко: аллергические реакции в
месте введения – раздражение, гиперемия или припухлость;
очень редко: в случае быстрого
введения препарата возможно повышение внутричерепного давления (возникает
чувство тяжести в голове), затруднение дыхания. Данные реакции проходят
самостоятельно.
· Если любые из указанных в инструкции побочных эффектов усугубляются, или
Вы заметили любые другие побочные эффекты не указанные в инструкции, сообщите
об этом врачу.
Передозировка
Симптомы:
тошнота, рвота, головная боль.
В случае приема
доз от 10 до 40 г тиоктовой кислоты в сочетании с алкоголем наблюдались случаи
интоксикации, вплоть до летального исхода.
Симптомы острой
передозировки: психомоторное возбуждение или помрачение сознания, как правило,
с последующим развитием генерализованных судорог и развитием лактоацидоза.
Также описаны случаи гипогликемии, шока, рабдомиолиза,гемолиза,диссеминированного
внутрисосудистого свертывания крови, депрессии костного мозга и мультиорганной
недостаточности.
Лечение симптоматическое. Специфического
антидота нет.
Взаимодействие с другими лекарственными средствами
Тиоктовая
кислота снижает эффективность цисплатина при одновременном приеме, а также
вступает в реакцию с металлсодержащими препаратами, такими как препараты
железа, магния.
Тиоктовая
кислота вступает в реакцию с молекулами сахаров, образуя труднорастворимые
комплексы, например, с раствором левулозы (фруктозы).
Усиливает противовоспалительное
действие глюкокортикостероидных средств.
Инфузионный раствор
тиоктовой кислоты несовместим с раствором декстрозы, раствором Рингера и с
растворами, реагирующими с дисульфидными и SH – группами. При одновременном
применении тиоктовой кислоты и инсулина или пероральных гипогликемических
препаратов их действие может усиливаться. Этанол и его метаболиты ослабляют
действие тиоктовой кислоты.
· В случае, если Вы уже принимаете
другие препараты или собираетесь их принимать, перед приемом препаратаТиогаммаÒ обязательно проконсультируйтесь с
врачом.
Особые указания
У пациентов c сахарным
диабетом необходим постоянный контроль концентрации глюкозы крови, особенно на
начальной стадии терапии. В некоторых случаях необходимо уменьшить дозу
инсулина или перорального гипогликемического препарата, чтобы избежать развития
гипогликемии. При возникновении симптомов гипогликемии (головокружение,
повышенное потоотделение, головная боль, расстройства зрения, тошнота) следует
немедленно прекратить терапию. В единичных случаях при применении препарата
Тиогамма®
у пациентов с отсутствием гликемического контроля и в тяжелом общем состоянии
могут развиться серьезные анафилактические реакции.
Употребление алкоголя в
период терапии препаратом Тиогамма® снижает эффективность препарата и
является фактором риска, способствующим развитию и прогрессированию нейропатии.
Пациентам, принимающим
препарат Тиогамма®, следует воздержаться от употребления алкоголя.
Описаны случаи развития
аутоиммунного инсулинового синдрома (АИС) во время лечения тиоктовой кислотой.
Возможность появления АИС определяется наличием у пациентов аллелей
HLA-DRB1*04:06 и HLA-DRB1*04:03.
Влияние на способность управлять автомобилем и движущимися механизмами
Не влияет на способность
к управлению автотранспортным средством и работу с другими механизмами.
Форма выпуска
Раствор для инфузий 12 мг/мл.
По 50 мл во флакон,
изготовленный из коричневого стекла тип II, который закрывается резиновой
пробкой. Пробка фиксируется с помощью алюминиевого колпачка, на верхней части
которого имеется полипропиленовая прокладка. По 1 флакону или по 10 флаконов с
подвесными светозащитными футлярами по количеству флаконов, изготовленными из
полиэтилена черного цвета, перегородками из картона и инструкцией по применению
в картонную пачку.
Условия хранения
В
защищенном от света месте при температуре не выше +25°С.
Хранить
в местах недоступных для детей!
Срок годности
5 лет.
Не использовать по истечении
срока, указанного на упаковке.
Условия отпуска
Отпускают
по рецепту.
Производитель
Солюфарм Фармацойтише Эрцойгниссе
ГмбХ, Индустриштрассе 3, 34212 Мельзунген, Германия
Организация, принимающая претензии потребителей
Представительство фирмы Верваг Фарма
ГмбХ и Ко. КГ в России.
117587, г. Москва, Варшавское шоссе, д. 125 Ж,
корп. 6.
Тел: +7 495 382-85-56
Для описания товара использована информация от партнера ЗдравСити
Мобильное приложение «Все аптеки»
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10 шт, 50 мл, 600 мг","short":"Раствор, 10 шт, 50 мл, 600 мг","package":"10 шт, 50 мл, 600 мг"},"prescription":true,"catalog_section_id":100253,"manufacturer":{"id":3156,"title":"Солюфарм","slug":"solyufarm_3156","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Раствор","slug":"98266-tiogamma","attributes":{"count":"10 шт","dose":"600 мг","volume":"50 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N013424/01"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"раствор для инфузий. "}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"1 флакон\n50 мл раствора для инфузий 12 мг/мл содержит "}},{"type":"paragraph","data":{"text":"\u003ci\u003eактивное вещество:\u003c/i\u003e меглуминовую соль тиоктовой кислоты - 1167,70 мг (что\nэквивалентно 600 мг тиоктовой кислоты); \u003ci\u003eвспомогательные\nвещества:\u003c/i\u003e макрогол 300 - 4000,00 мг, меглумин, вода для инъекций до 50 мл.\u003cb\u003e \u003c/b\u003e"}}]},{"id":1,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Прозрачный раствор светло-желтого или желтовато-зеленого цвета."}}]},{"id":5,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Метаболическое средство."}}]},{"id":6,"name":"Фармакологические свойства","slug":"","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Тиоктовая (альфа-липоевая) кислота –\nэндогенный антиоксидант прямого (связывает свободные радикалы) и непрямого\nдействия (восстанавливает физиологическую концентрацию глутатиона, повышает\nактивность супероксиддисмутазы). "}},{"type":"paragraph","data":{"text":"В качестве кофермента\nмитохондриальных мультиферментных комплексов участвует в реакциях\nокислительного фосфорилирования пировиноградной кислоты (ПВК) и\nальфа-кетокислот. "}},{"type":"paragraph","data":{"text":"По биохимическому механизму действия близка\nк витаминам группы B."}},{"type":"paragraph","data":{"text":"Тиоктовая кислота оказывает\nантиоксидантное, нейротрофическое, гипогликемическое действие, улучшает\nметаболизм липидов:"}},{"type":"paragraph","data":{"text":"- связываясь с избыточным количеством\nсвободных кислородных радикалов, защищает клетки от повреждения продуктами\nраспада; при сахарном диабете уменьшает образование конечных продуктов\nпрогрессирующего гликирования белков в нервных клетках, уменьшает\nэндоневральную гипоксию и ишемию, повышает концентрацию антиоксиданта\nглутатиона, тем самым, ослабляя проявления полинейропатии в виде парестезии,\nощущения жжения, боли и онемения конечностей;"}},{"type":"paragraph","data":{"text":"- участвует в регулировании\nуглеводного обмена (способствует снижению концентрации глюкозы в плазме крови и\nувеличению концентрации гликогена в печени, снижает инсулинорезистентность\nтканей);"}},{"type":"paragraph","data":{"text":"- стимулирует метаболизм холестерина,\nснижая его концентрацию в плазме крови; участвуя в метаболизме жиров, тиоктовая\nкислота увеличивает биосинтез фосфолипидов, в частности фосфоинозитидов,\nблагодаря чему восстанавливается поврежденная структура клеточных мембран;\nнормализуется энергетический обмен и проведение нервных импульсов."}},{"type":"header","data":{"text":"Фармакокинетика","level":4}},{"type":"paragraph","data":{"text":"При внутривенном введении\nвремя достижения максимальной концентрации – 10 – 11 мин, максимальная концентрация\nсоставляет около 20 мкг/мл. Обладает эффектом «первого прохождения» через\nпечень. Образование метаболитов происходит в результате окисления боковой цепи\nи конъюгирования. Общий плазменный клиренс – 10 - 15 мл/мин. Тиоктовая кислота и ее\nметаболиты выводится почками (80 – 90 %), в небольшом количестве – в неизменном\nвиде. Период полувыведения составляет 25 мин."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Диабетическая\nполинейропатия, алкогольная полинейропатия. "}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к\nтиоктовой кислоте или другим компонентам препарата."}},{"type":"paragraph","data":{"text":"Детский возраст до 18 лет. "}},{"type":"paragraph","data":{"text":"Беременность и период грудного\nвскармливания. "}},{"type":"list","data":{"style":"ordered","items":["\u003ci\u003e \n Перед приемом препарата обязательно проконсультируйтесь с врачом.\u003c/i\u003e"]}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение при беременности и в\nпериод лактации противопоказано. "}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"В начале терапии препарат\nТиогамма\u003csup\u003e®\u003c/sup\u003e, раствор для инфузий, вводят внутривенно в дозе 600 мг (1\nфлакон) в сутки в течение 2-4 недель. Флакон с препаратом вынимают из коробки и\nнемедленно накрывают прилагаемым светозащитным футляром, т.к. тиоктовая кислота\nчувствительна к свету. Инфузию производят непосредственно из флакона, используя\nустройство (систему) для внутривенного вливания инфузионных растворов. Вводят\nмедленно, около 1,7 мл/мин, в течение 30 мин."}},{"type":"paragraph","data":{"text":"Затем переходят на\nподдерживающую терапию препаратом тиоктовой кислоты для перорального применения\nв дозе 600 мг в сутки. Продолжительность курса терапии и необходимость его\nповторения определяется лечащим врачом. "}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота проявления неблагоприятных побочных\nреакций приведена в соответствии с классификацией ВОЗ:"}},{"type":"paragraph","data":{"text":"Очень часто: ≥ 1/10 назначений"}},{"type":"paragraph","data":{"text":"Часто: ≥ 1/100 до ≤ 1/10 назначений"}},{"type":"paragraph","data":{"text":"Не часто: ≥ 1/1000 до ≤ 1/100 назначений"}},{"type":"paragraph","data":{"text":"Редко: ≥ 1/10000 до ≤ 1/1000 назначений"}},{"type":"paragraph","data":{"text":"Очень редко: ≤ 1/ 10000 назначений"}},{"type":"paragraph","data":{"text":"Частота неизвестна: невозможно установить из имеющихся\n данных"}},{"type":"paragraph","data":{"text":"Нарушения\nсо стороны крови и лимфатической системы:"}},{"type":"paragraph","data":{"text":"очень редко: точечные кровоизлияния в\nслизистые оболочки, кожу, тромбоцитопения, геморрагическая сыпь (пурпура),\nтромбофлебит;"}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной\nсистемы:"}},{"type":"paragraph","data":{"text":"частота неизвестна: системные\nаллергические реакции (вплоть до развития анафилактического шока);"}},{"type":"paragraph","data":{"text":"частота неизвестна: аутоиммунный\nинсулиновый синдром (АИС) у пациентов с сахарным диабетом, который\nхарактеризуется частыми гипогликемиями в условиях наличия аутоантител к\nинсулину. "}},{"type":"paragraph","data":{"text":"Нарушения\nсо стороны нервной системы: "}},{"type":"paragraph","data":{"text":"очень редко: изменение или нарушение\nвкусовых ощущений;"}},{"type":"paragraph","data":{"text":"очень редко: судороги;"}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа зрения:"}},{"type":"paragraph","data":{"text":"очень редко: диплопия;"}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных\nтканей:"}},{"type":"paragraph","data":{"text":"частота неизвестна: аллергические\nреакции - крапивница, зуд, экзема, сыпь."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в\nместе введения:"}},{"type":"paragraph","data":{"text":"частота неизвестна: в связи с\nулучшением усвоения глюкозы возможно снижение концентрации глюкозы в крови. При\nэтом могут возникнуть симптомы гипогликемии – головокружение, повышенное\nпотоотделение, головная боль, расстройства зрения;"}},{"type":"paragraph","data":{"text":"очень редко: аллергические реакции в\nместе введения – раздражение, гиперемия или припухлость;"}},{"type":"paragraph","data":{"text":"очень редко: в случае быстрого\nвведения препарата возможно повышение внутричерепного давления (возникает\nчувство тяжести в голове), затруднение дыхания. Данные реакции проходят\nсамостоятельно. "}},{"type":"paragraph","data":{"text":"· \u003ci\u003eЕсли любые из указанных в инструкции побочных эффектов усугубляются, или\nВы заметили любые другие побочные эффекты не указанные в инструкции, \u003cb\u003eсообщите\nоб этом врачу\u003c/b\u003e.\u003c/i\u003e"}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы:\nтошнота, рвота, головная боль."}},{"type":"paragraph","data":{"text":"В случае приема\nдоз от 10 до 40 г тиоктовой кислоты в сочетании с алкоголем наблюдались случаи\nинтоксикации, вплоть до летального исхода. "}},{"type":"paragraph","data":{"text":"Симптомы острой\nпередозировки: психомоторное возбуждение или помрачение сознания, как правило,\nс последующим развитием генерализованных судорог и развитием лактоацидоза.\nТакже описаны случаи гипогликемии, шока, рабдомиолиза,\u003cb\u003e \u003c/b\u003eгемолиза,\u003cb\u003e \u003c/b\u003eдиссеминированного\nвнутрисосудистого свертывания крови, депрессии костного мозга и мультиорганной\nнедостаточности."}},{"type":"paragraph","data":{"text":" Лечение симптоматическое. Специфического\nантидота нет."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Тиоктовая\nкислота снижает эффективность цисплатина при одновременном приеме, а также\nвступает в реакцию с металлсодержащими препаратами, такими как препараты\nжелеза, магния. "}},{"type":"paragraph","data":{"text":"Тиоктовая\nкислота вступает в реакцию с молекулами сахаров, образуя труднорастворимые\nкомплексы, например, с раствором левулозы (фруктозы). "}},{"type":"paragraph","data":{"text":"Усиливает противовоспалительное\nдействие глюкокортикостероидных средств."}},{"type":"paragraph","data":{"text":"Инфузионный раствор\nтиоктовой кислоты несовместим с раствором декстрозы, раствором Рингера и с\nрастворами, реагирующими с дисульфидными и SH – группами. При одновременном\nприменении тиоктовой кислоты и инсулина или пероральных гипогликемических\nпрепаратов их действие может усиливаться. Этанол и его метаболиты ослабляют\nдействие тиоктовой кислоты."}},{"type":"paragraph","data":{"text":"· \u003ci\u003e В случае, если Вы уже принимаете\nдругие препараты или собираетесь их принимать, перед приемом препарата\u003c/i\u003e \u003ci\u003eТиогамма\u003c/i\u003e\u003csup\u003eÒ\u003c/sup\u003e\u003ci\u003e обязательно проконсультируйтесь с\nврачом.\u003c/i\u003e"}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"У пациентов c сахарным\nдиабетом необходим постоянный контроль концентрации глюкозы крови, особенно на\nначальной стадии терапии. В некоторых случаях необходимо уменьшить дозу\nинсулина или перорального гипогликемического препарата, чтобы избежать развития\nгипогликемии. При возникновении симптомов гипогликемии (головокружение,\nповышенное потоотделение, головная боль, расстройства зрения, тошнота) следует\nнемедленно прекратить терапию. В единичных случаях при применении препарата\nТиогамма\u003csup\u003e®\u003c/sup\u003e\nу пациентов с отсутствием гликемического контроля и в тяжелом общем состоянии\nмогут развиться серьезные анафилактические реакции."}},{"type":"paragraph","data":{"text":"Употребление алкоголя в\nпериод терапии препаратом Тиогамма\u003csup\u003e®\u003c/sup\u003e снижает эффективность препарата и\nявляется фактором риска, способствующим развитию и прогрессированию нейропатии."}},{"type":"paragraph","data":{"text":"Пациентам, принимающим\nпрепарат Тиогамма\u003csup\u003e®\u003c/sup\u003e, следует воздержаться от употребления алкоголя."}},{"type":"paragraph","data":{"text":"Описаны случаи развития\nаутоиммунного инсулинового синдрома (АИС) во время лечения тиоктовой кислотой.\nВозможность появления АИС определяется наличием у пациентов аллелей\nHLA-DRB1*04:06 и HLA-DRB1*04:03."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не влияет на способность\nк управлению автотранспортным средством и работу с другими механизмами. "}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для инфузий 12 мг/мл."}},{"type":"paragraph","data":{"text":"По 50 мл во флакон,\nизготовленный из коричневого стекла тип II, который закрывается резиновой\nпробкой. Пробка фиксируется с помощью алюминиевого колпачка, на верхней части\nкоторого имеется полипропиленовая прокладка. По 1 флакону или по 10 флаконов с\nподвесными светозащитными футлярами по количеству флаконов, изготовленными из\nполиэтилена черного цвета, перегородками из картона и инструкцией по применению\nв картонную пачку."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В\nзащищенном от света месте при температуре не выше +25°С."}},{"type":"paragraph","data":{"text":"Хранить\nв местах недоступных для детей!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. "}},{"type":"paragraph","data":{"text":"Не использовать по истечении\nсрока, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают\nпо рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Солюфарм Фармацойтише Эрцойгниссе\nГмбХ, Индустриштрассе 3, 34212 Мельзунген, Германия"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Представительство фирмы Верваг Фарма\nГмбХ и Ко. КГ в России."}},{"type":"paragraph","data":{"text":"117587, г. Москва, Варшавское шоссе, д. 125 Ж,\nкорп. 6."}},{"type":"paragraph","data":{"text":"Тел: +7 495 382-85-56"}}]}],"source":{"title":"ЗдравСити","url":"https://zdravcity.ru"}},"description_toggle":false,"short_description":"Прозрачный раствор светло-желтого или желтовато-зеленого цвета.","substance":[{"id":171,"title":"Тиоктовая кислота","title_latin":"Acidum thiocticum","slug":"tioktovaya_kislota_171"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Тиогамма - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60503/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60503/share_default/"}},"diseases":[{"id":"573","title":"Алкогольная полиневропатия","slug":"573-alkogolnaya_polinevropatiya"},{"id":"575","title":"Диабетическая 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