Активное вещество: тербинафина гидрохлорид – 0,15 г или 0,30 г;
Вспомогательные вещества: этанол (спирт этиловый ректификованный) – 5,625 г или 11,25 г, пропиленгликоль – 0,30 г или 0,60 г, полоксамер – 0,15 г или 0,30 г, вода очищенная – 8,775 г или 17,55 г.
Описание
ТЕРМИКОН — современный противогрибковый препарат для лечения и профилактики грибка кожи.
Фармакотерапевтическая группа
Противогрибковое средство
Фармакологические свойства
Противогрибковый препарат для местного применения, обладающий широким спектром противогрибковой активности. В низких концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых, определенных диморфных (Pityrosporum orbiculare) и дрожжевых грибов (в основном Сandida albicans).
Активность в отношении дрожжевых грибов, в зависимости от их вида, может быть фунгицидной или фунгистатической.
Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящий в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба.
Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба.
Тербинафин не оказывает влияния на систему цитохрoма P450 у человека и, соответственно, на метаболизм гормонов или других лекарственных препаратов.
Показания к применению
Профилактика и лечение грибковых инфекций кожи, в том числе:
Повышенная чувствительность к тербинафину или к вспомогательным веществам, входящим в состав препарата, детский возраст до 18 лет.
С осторожностью
Печеночная и/или почечная недостаточность, алкоголизм, угнетение костномозгового кроветворения, опухоли, болезни обмена веществ, окклюзионные заболевания сосудов конечностей.
Применение при беременности и в период грудного вскармливания
В экспериментальных исследованиях тератогенных свойств тербинафина выявлено не было. До настоящего времени не сообщалось о каких-либо пороках развития при применении Термикона . Однако, поскольку клинический опыт применения Термикона у беременных женщин очень ограничен, его следует применять только по строгим показаниям.
Тербинафин выделяется с грудным молоком. Однако, в случае применения кормящей матерью Термикона спрея через кожу всасывается небольшое количество активного вещества, поэтому неблагоприятное воздействие на младенца маловероятно.
Способ применения и дозы
Наружно.
Взрослые. Термикон спрей можно применять 1 или 2 раза в день, в зависимости от показаний. Перед применением препарата тщательно очистить и подсушить пораженные участки кожи.
Для обеспечения равномерного распыления содержимого предварительно произвести несколько кратковременных нажатий на насадку-распылитель.
Препарат наносят на пораженные участки кожи и прилегающие участки здоровой кожи в достаточном для их увлажнения количестве.
Кратность применения препарата и продолжительность лечения:
– дерматомикоз туловища, голеней: 1 раз в сутки в течении 1 недели;
– дерматомикоз стоп: 1 раз в сутки в течении 1 недели;
– разноцветный лишай: 2 раза в сутки в течении 1 недели;
– паховая эпидермофития, опрелость, вызванная плесневыми грибами: 1 раз в сутки в течении 1 недели.
Побочное действие
В местах нанесения препарата может появиться покраснение, ощущение зуда или жжения.
Аллергические реакции.
Передозировка
О случаях передозировки препарата не сообщалось. Если же случайно Термикон спрей будет принят внутрь, можно ожидать развития таких же побочных явлений, как и при передозировке таблеток Термикон (головная боль, тошнота, боли в эпигастрии и головокружение). Следует также учитывать содержание в препарате этилового спирта.
Лечение: активированный уголь, при необходимости – симптоматическая поддерживающая терапия.
Взаимодействие с другими лекарственными средствами
Какие-либо лекарственные взаимодействия для спрея Термикон не известны.
Особые указания
Уменьшение выраженности клинических проявлений обычно отмечается в первые дни лечения. В случае нерегулярного лечения или преждевременного его прекращения имеется риск рецидива инфекции. В том случае, если через неделю лечения не отмечается признаков улучшения, следует верифицировать диагноз.
Следует соблюдать осторожность при нанесении спрея Термикон на поврежденные участки кожи, так как спирт может вызвать раздражение.
Термикон спрей предназначен только для наружного применения. Следует избегать попадания его в глаза, так как он может вызвать раздражение. При случайном попадании препарата в глаза, их следует немедленно промыть проточной водой, а в случае развития стойких явлений раздражения необходимо проконсультироваться с врачом.
Если препарат был случайно введен в дыхательные пути при ингаляции, то, в случае появления каких-либо симптомов и особенно при их стойком сохранении, необходимо проконсультироваться с врачом.
При развитии аллергических реакций необходимо отменить препарат.
Влияние на способность управлять автомобилем и движущимися механизмами
Данных о влиянии препарата на способность к управлению транспортными средствами или работе с другими механизмами нет.
Форма выпуска
Спрей для наружного применения 1%
Условия хранения
При температуре не выше 30 °C. Не замораживать. Хранить в недоступном для детей месте.
Срок годности
3 года. Не использовать по истечении срока годности, указанного на упаковке.
Условия отпуска
Без рецепта
Производитель
ОАО "Фармстандарт-Лексредства"
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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В низких концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых, определенных диморфных (Pityrosporum orbiculare) и дрожжевых грибов (в основном Сandida albicans)."}},{"type":"paragraph","data":{"text":"Активность в отношении дрожжевых грибов, в зависимости от их вида, может быть фунгицидной или фунгистатической."}},{"type":"paragraph","data":{"text":"Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящий в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба."}},{"type":"paragraph","data":{"text":"Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба."}},{"type":"paragraph","data":{"text":"Тербинафин не оказывает влияния на систему цитохрoма P450 у человека и, соответственно, на метаболизм гормонов или других лекарственных препаратов.\n\n"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nПрофилактика и лечение грибковых инфекций кожи, в том числе:"}},{"type":"paragraph","data":{"text":"- микозов стоп («грибок» стопы),"}},{"type":"paragraph","data":{"text":"- паховой эпидермофитии,"}},{"type":"paragraph","data":{"text":"- грибковых поражений гладкой кожи тела, вызванных дерматофитами (трихофитии, микроспории, эпидермофитии, руброфитии)."}},{"type":"paragraph","data":{"text":"Разноцветный лишай, вызванный диморфными грибами."}},{"type":"paragraph","data":{"text":"Опрелость, вызванная плесневыми грибами.\n\n"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к тербинафину или к вспомогательным веществам, входящим в состав препарата, детский возраст до 18 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Печеночная и/или почечная недостаточность, алкоголизм, угнетение костномозгового кроветворения, опухоли, болезни обмена веществ, окклюзионные заболевания сосудов конечностей."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\n\nВ экспериментальных исследованиях тератогенных свойств тербинафина выявлено не было. До настоящего времени не сообщалось о каких-либо пороках развития при применении Термикона . Однако, поскольку клинический опыт применения Термикона у беременных женщин очень ограничен, его следует применять только по строгим показаниям."}},{"type":"paragraph","data":{"text":"Тербинафин выделяется с грудным молоком. Однако, в случае применения кормящей матерью Термикона спрея через кожу всасывается небольшое количество активного вещества, поэтому неблагоприятное воздействие на младенца маловероятно.\n\n"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nНаружно."}},{"type":"paragraph","data":{"text":"Взрослые. Термикон спрей можно применять 1 или 2 раза в день, в зависимости от показаний. Перед применением препарата тщательно очистить и подсушить пораженные участки кожи."}},{"type":"paragraph","data":{"text":"Для обеспечения равномерного распыления содержимого предварительно произвести несколько кратковременных нажатий на насадку-распылитель."}},{"type":"paragraph","data":{"text":"Препарат наносят на пораженные участки кожи и прилегающие участки здоровой кожи в достаточном для их увлажнения количестве."}},{"type":"paragraph","data":{"text":"Кратность применения препарата и продолжительность лечения:"}},{"type":"paragraph","data":{"text":"– дерматомикоз туловища, голеней: 1 раз в сутки в течении 1 недели;"}},{"type":"paragraph","data":{"text":"– дерматомикоз стоп: 1 раз в сутки в течении 1 недели;"}},{"type":"paragraph","data":{"text":"– разноцветный лишай: 2 раза в сутки в течении 1 недели;"}},{"type":"paragraph","data":{"text":"– паховая эпидермофития, опрелость, вызванная плесневыми грибами: 1 раз в сутки в течении 1 недели.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nВ местах нанесения препарата может появиться покраснение, ощущение зуда или жжения."}},{"type":"paragraph","data":{"text":"Аллергические реакции.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nО случаях передозировки препарата не сообщалось. Если же случайно Термикон спрей будет принят внутрь, можно ожидать развития таких же побочных явлений, как и при передозировке таблеток Термикон (головная боль, тошнота, боли в эпигастрии и головокружение). Следует также учитывать содержание в препарате этилового спирта."}},{"type":"paragraph","data":{"text":"Лечение: активированный уголь, при необходимости – симптоматическая поддерживающая терапия.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Какие-либо лекарственные взаимодействия для спрея Термикон не известны."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nУменьшение выраженности клинических проявлений обычно отмечается в первые дни лечения. В случае нерегулярного лечения или преждевременного его прекращения имеется риск рецидива инфекции. В том случае, если через неделю лечения не отмечается признаков улучшения, следует верифицировать диагноз."}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при нанесении спрея Термикон на поврежденные участки кожи, так как спирт может вызвать раздражение."}},{"type":"paragraph","data":{"text":"Термикон спрей предназначен только для наружного применения. Следует избегать попадания его в глаза, так как он может вызвать раздражение. При случайном попадании препарата в глаза, их следует немедленно промыть проточной водой, а в случае развития стойких явлений раздражения необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Если препарат был случайно введен в дыхательные пути при ингаляции, то, в случае появления каких-либо симптомов и особенно при их стойком сохранении, необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"При развитии аллергических реакций необходимо отменить препарат.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Данных о влиянии препарата на способность к управлению транспортными средствами или работе с другими механизмами нет."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Спрей для наружного применения 1%"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 30 °C. Не замораживать. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\""}}]}],"source":null},"description_toggle":false,"short_description":"Противогрибковый препарат для местного применения, обладающий широким спектром противогрибковой активности. В низких концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых, определенных диморфных (Pityrosporum orbiculare) и дрожжевых грибов (в основном Сandida albicans). 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