Таблетки Тетурам используются как средство для лечения алкогольной зависимости.
Фармакологические свойства
Тетурам ингибирует ацетальдегиддегидрогеназу, участвующую в метаболизме этанола, увеличивает концентрацию ацетальдегида, являющегося метаболитом этанола и вызывающего ряд неприятных ощущений после его употребления ("приливы" крови к коже лица, тошноту, рвоту, чувство недомогания, тахикардию, понижение АД).
Показания к применению
Лечение и профилактика рецидивов хронического алкоголизма, в качестве дезинтоксикационного средства при хроническом отравлении никелем.
Противопоказания
Абсолютные: тяжелые заболевания сердечно-сосудистой системы, органа слуха (невриты слухового нерва), органа зрения (глаукома, неврит зрительного нерва), бронхиальная астма, эмфизема легких, туберкулез легких, тяжелая печеночная недостаточность, болезни кроветворных органов, сахарный диабет, тиреотоксикоз, эпилепсия, судорожный синдром любого генеза, психические заболевания, обострение язвенной болезни, болезни почек, злокачественные опухоли, полиневриты любой этиологии, беременность, повышенная индивидуальная чувствительность к препарату. Относительные: сердечно-сосудистые заболевания в стадии компенсации, пожилой возраст (старше 60 лет), язвенная болезнь желудка и 12-перстной кишки в стадии ремиссии, остаточные явления после НМК, ранее перенесенные тетурамные (антабусные) психозы.
Применение при беременности и в период грудного вскармливания
Противопоказан во время беременности и в период лактации.
Способ применения и дозы
Лечение назначается после тщательного обследования больного и предупреждения о последствиях и осложнениях. Препарат принимается внутрь по 150-500 мг 2 раза в сутки по индивидуальной схеме. Через 7-10 дней проводят тетурамалкогольную пробу (20-30 мл 40% водки после приема 500 мг препарата), при слабой реакции дозу алкоголя увеличивают на 10-20 мл (максимальная доза водки 100-120 мл). Пробу повторяют через 1-2 дня в стационаре и через 3-5 дней амбулаторно, с коррекцией доз алкоголя и/или препарата по необходимости. В дальнейшем можно использовать поддерживающую дозу 150-200 мг в сутки в течение 1-3 лет.
Побочное действие
В период лечения Тетурамом может появиться горький привкус в полости рта, головная боль, головокружение, расстройство памяти, бессонница, тревожность. Наиболее частыми побочными эффектами Тетурама являются аллергические реакции – крапивница, кожная сыпь, отек Квинке, бронхоспазм, дерматит. При имплантации таблеток Тетурама может возникнуть отторжение, проявляющее в виде коллапса, аритмии, отека мозга, нагноениях, инфаркте.
Передозировка
Симптомы: комбинация тетурам-этанол может вызвать угнетение сознания вплоть до комы, сердечно-сосудистый коллапс, неврологические осложнения. Лечение: симптоматическое.
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