Противомикробное средство широкого спектра действия, фторхин... Инструкция
Показания к применению
Инфекционно-воспалительные заболевания легкой и средней степени тяжести, вызванные чувствительными к препарату возбудителями: Внебольничная пневмония. Лекарственно-устойчивые формы туберкулеза (в составе комплексной терапии). Осложненные инфекции почек и мочевыводящих путей, включая пиелонефрит. Неосложненные инфекции мочевыводящих путей. Простатит, ...
Повышенная чувствительность к левофлоксацину или другим хинолонам. Повышенная чувствительность к вспомогательным компонентам леволета. Эпилепсия. Поражения сухожилий, связанные с приемом хинолонов в анамнезе. Детский и подростковый возраст до 18 лет. Беременность. Период лактации (грудного вскармливания). С осторожностью: Пожилой возраст (высокая вероятность ...
Противомикробное средство широкого спектра действия, фторхинолон. Действует бактерицидно. Блокирует ДНК-гиразу (топоизомеразу II) и топоизомеразу IV, нарушает суперспирализацию и сшивку разрывов ДНК, ингибирует синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембранах. Активен в отношении Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes и Streptococcus agalactiae, Viridans group streptococci, Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichia coli, Haemophilus influеnzае, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Chlamydia pneumoniae, Mycoplasma pneumoniae, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Morganella morganii, Proteus vulgaris, Providencia rettgeri, Providcncia stuartii, Serratia marcescens, Clostridium perfringens.
Показания к применению
Инфекционно-воспалительные заболевания легкой и средней степени тяжести, вызванные чувствительными к препарату возбудителями: Внебольничная пневмония. Лекарственно-устойчивые формы туберкулеза (в составе комплексной терапии). Осложненные инфекции почек и мочевыводящих путей, включая пиелонефрит. Неосложненные инфекции мочевыводящих путей. Простатит, в т.ч. Бактериальный. Септицемия/бактериемия, связанная с указанными выше Показания к применениюми. Интраабдоминальная инфекция. Инфекции лop-органов (острый синусит). Инфекции нижних дыхательных путей (обострение хронического бронхита). Инфекции кожи и мягких тканей.
Противопоказания
Повышенная чувствительность к левофлоксацину или другим хинолонам. Повышенная чувствительность к вспомогательным компонентам леволета. Эпилепсия. Поражения сухожилий, связанные с приемом хинолонов в анамнезе. Детский и подростковый возраст до 18 лет. Беременность. Период лактации (грудного вскармливания). С осторожностью: Пожилой возраст (высокая вероятность наличия сопутствующего снижения функции почек). Дефицит глюкозо-6-фосфатдегидрогеназы.
Применение при беременности и в период грудного вскармливания
Левофлоксацин противопоказан к применению при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Внутрь, до еды или в перерыве между приемами пищи, не разжевывая, запивая достаточным количеством жидкости. Синусит: по 500 мг 1 раз в сутки. Курс лечения - 10–14 дней. Обострение хронического бронхита: по 250–500 мг 1 раз в сутки. Курс лечения - 10–14 дней. Инфекции кожи и мягких тканей: по 250 мг 1–2 раза в сутки или по 500 мг 1 раз в сутки. Курс лечения - 7–14 дней.
Побочное действие
Частота развития побочных эффектов классифицируется в зависимости от частоты встречаемости часто (1–10%), иногда (менее 0,1–1%), редко (0,01–0,1%), очень редко (менее 0,01%), включая отдельные сообщения. Со стороны системы крови и органов кроветворения иногда - эозинофилия, лейкопения. редко - нейтропения, тромбоцитопения. очень редко - выраженный агранулоцитоз. в отдельных случаях - гемолитическая анемия, панцитопения. Со стороны пищеварительной системы часто - тошнота, диарея, повышение активности АЛТ, ACT, дисбактериоз. иногда - потеря аппетита, рвота, боли в животе, нарушения пищеварения, гипербилирубинемия. редко - диарея с примесью крови (в очень редких случаях это может являться признаком воспаления кишечника или псевдомембранозного колита). очень редко - гепатит. Со стороны сердечно-сосудистой системы редко - тахикардия, снижение АД. очень редко - сосудистый коллапс. в отдельных случаях - удлинение интервала QT. Со стороны центральной и периферической нервной системы иногда - головная боль, головокружение, скованность движений, сонливость, нарушение сна. редко - парестезии в кистях, дрожь, беспокойство, состояния страха, приступы судорог, спутанность сознания. очень редко - психотические реакции типа галлюцинаций и депрессий, нарушения движений. Со стороны органов чувств очень редко - нарушения зрения и слуха, обоняния, вкусовой и тактильной чувствительности. Со стороны обмена веществ очень редко - гипогликемия (проявляющаяся резким повышением аппетита, нервозностью, испариной, дрожью). в отдельных случаях - обострение имеющейся порфирии. Со стороны мочевыделительной системы редко - гиперкреатининемия. очень редко - ухудшение функции почек вплоть до острой почечной недостаточности (например вследствие аллергических реакций - интерстициальный нефрит). Со стороны костно-мышечной системы редко - поражения сухожилий (включая тендинит), суставные и мышечные боли. очень редко - разрывы сухожилия (в т.ч. Ахиллова, которые могут носить двусторонний характер и проявляться в течение 48 ч после начала лечения), мышечная слабость (имеет особое значение для больных миастенией). в отдельных случаях - рабдомиолиз. Аллергические реакции иногда - зуд и покраснение кожи. редко - анафилактические и анафилактоидные реакции (проявляющиеся такими симптомами, как крапивница, бронхоспазм и возможное тяжелое удушье, а также в редких случаях - отек лица, гортани). очень редко - резкое снижение АД, анафилактический шок. в отдельных случаях - синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла) и экссудативная мультиформная эритема, аллергический пневмонит, васкулит. Дерматологические реакции очень редко - фотосенсибилизация. Прочие иногда - астения. очень редко - стойкая лихорадка, развитие суперинфекции.
Особые указания
С осторожностью применяют левофлоксацин пациентам пожилого возраста (высокая вероятность наличия сопутствующего снижения функции почек). После нормализации температуры рекомендуется продолжать лечение не менее 48-78 ч. Длительность в/в вливания 500 мг (100 мл инфузиоиного раствора) должна составлять не менее 60 мин. Во время лечения необходимо избегать солнечного и искусственного УФ облучения во избежание повреждения кожных покровов (фотосенсибилизация). При появлении признаков тендинита левофлоксацин немедленно отменяют. Следует иметь в виду, что у больных с поражением головного мозга в анамнезе (инсульт, тяжелая травма) возможно развитие судорог, при недостаточности глюкoзo-6-фосфатдeгидpoгeназы - риск развития гемолиза. Влияние на способность к вождению автотранспорта и управлению механизмами В период лечения необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
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Лекарственно-устойчивые формы туберкулеза (в составе комплексной терапии). Осложненные инфекции почек и мочевыводящих путей, включая пиелонефрит. Неосложненные инфекции мочевыводящих путей. Простатит, в т.ч. Бактериальный. Септицемия/бактериемия, связанная с указанными выше Показания к применениюми. Интраабдоминальная инфекция. Инфекции лop-органов (острый синусит). Инфекции нижних дыхательных путей (обострение хронического бронхита). Инфекции кожи и мягких тканей."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к левофлоксацину или другим хинолонам. Повышенная чувствительность к вспомогательным компонентам леволета. Эпилепсия. Поражения сухожилий, связанные с приемом хинолонов в анамнезе. Детский и подростковый возраст до 18 лет. Беременность. Период лактации (грудного вскармливания). 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