Симвор Таблетки, 30 шт, 20 мг

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Суточная доза Симвора у пациентов, принимающих одновременно с ним амиодарон или верапамил , не должна превышать 20 мг."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Пищеварительная системаВозможны боли в животе, запор, метеоризм, тошнота , диарея, панкреатит , рвота, гепатит, повышение активности «печеночных» ферментов, щелочной фосфатазы и креатинфосфокиназы (КФК) . Нервная система и органы чувствАстенический синдром, головная боль, Головокружение , Бессонница , мышечные судороги, Парестезии , периферическая нейропатия, расплывчатость зрения, нарушение вкусовых ощущений. Аллергические и иммунопатологические реакцииАнгионевротический отек, ревматическая полимиалгия, васкулит, тромбоцитопения, увеличение СОЭ , лихорадка, артрит, крапивница, фотосенсибилизация, гиперемия кожи, приливы, одышка, волчаночноподобный синдром, эозинофилия. Дерматологические реакцииРедко кожная сыпь, зуд, алопеция, дерматомиозит. Со стороны опорно-двигательного аппаратаМиопатия, миалгия, судороги мышц, слабость. Редко - рабдомиолиз. ПрочиеАнемия, сердцебиение, острая почечная недостаточность (вследствие рабдомиолиза), снижение потенции."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: ни в одном из известных нескольких случаев передозировки (максимально принятая доза 450 мг) специфических симптомов выявлено не было. Лечение: вызвать рвоту, принять активированный уголь . Симптоматическая терапия. Следует контролировать функции печени и почек, уровень КФК в сыворотке крови . При развитии миопатии с рабдомиолизом и острой почечной недостаточностью (редкий, но тяжелый побочный эффект) следует немедленно прекратить прием препарата и ввести больному диуретик и натрия бикарбонат (внутривенная инфузия). При необходимости показан гемодиализ. Рабдомиолиз может вызвать гиперкалиемию, которую можно устранить внутривенным введением кальция хлорида и кальция глюконата , инфузией глюкозы с инсулином, использованием калиевых ионообменников или в тяжелых случаях с помощью гемодиализа."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Гиполипидемическое средство, получаемое синтетическим путем из продукта ферментации Aspergillus terreus, является неактивным лактоном, в организме подвергается гидролизу с образованием гидроксикислотного производного. Активный метаболит ингибирует 3-гидрокси-З-метил-глутарил-КоА-редуктазу (ГМГ-КоА редуктазу), фермент, катализирующий начальную реакцию образования мевалоната из ГМГ-КоА. Поскольку превращение ГМГ-КоА в мевалонат представляет собой ранний этап синтеза холестерина, то применение симвастатина не вызывает накопления в организме потенциально токсичных стеролов. ГМГ-КоА легко метаболизируется до ацетил-КоА, который участвует во многих процессах синтеза в организме. Снижает содержание триглицеридов (ТГ) , липопротеидов низкой плотности (ЛПНП) , липопротеидов очень низкой плотности (ЛПОНП) и общего холестерина в плазме (в случаях гетерозиготной семейной и несемейной форм гиперхолестеринемии, при смешанной гиперлипидемии, когда повышенное содержание холестерина является фактором риска). Повышает содержание липопротеидов высокой плотности (ЛПВП) и уменьшает соотношение ЛПНП/ЛПВП и общий холестерин/ЛПВП. Начало проявления эффекта - через 2 недели от начала приема, максимальный терапевтический эффект достигается через 4-6 недель. 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