Рак молочной железы у женщин в менопаузе, рак грудной железы у мужчин после кастрации, рак почки, меланома (содержащая эстрогенные рецепторы), рак яичников; рак предстательной железы при резистентности к другим лекарственным средствам.
Противопоказания
Тромбофлебит, беременность, повышенная чувствительность к тамоксифену.
Противоопухолевое средство. Антиэстроген. Блокирует рецепторы эстрогенов и таким образом тормозит прогрессирование опухолевого заболевания, стимулируемого эстрогенами.
Показания к применению
Рак молочной железы у женщин в менопаузе, рак грудной железы у мужчин после кастрации, рак почки, меланома (содержащая эстрогенные рецепторы), рак яичников; рак предстательной железы при резистентности к другим лекарственным средствам.
Противопоказания
Тромбофлебит, беременность, повышенная чувствительность к тамоксифену.
Применение при беременности и в период грудного вскармливания
Тамоксифен противопоказан к применению при беременности. При необходимости применения в период лактации следует прекратить грудное вскармливание.; В экспериментальных исследованиях установлено тератогенное действие тамоксифена.
Способ применения и дозы
Режим дозирования устанавливают индивидуально, в зависимости от показаний, состояния пациента и применяемой схемы противоопухолевой терапии.
Побочное действие
Со стороны пищеварительной системы: тошнота, рвота, повышение активности печеночных трансаминаз; в отдельных случаях - жировая инфильтрация печени, холестаз, гепатит.; Со стороны ЦНС: редко - депрессия, головокружение, головная боль, ретробульбарный неврит.; Со стороны органа зрения: редко - ретинопатия, кератопатия, катаракта.; Со стороны системы кроветворения: редко - тромбоцитопения, лейкопения.; Со стороны эндокринной системы: у женщин - гиперплазия эндометрия, вагинальные кровотечения, приливы, увеличение массы тела; у мужчин - импотенция, снижение либидо.; Со стороны сердечно-сосудистой системы: отеки, тромбоэмболия, флебит.; Дерматологические реакции: алопеция, сыпь, зуд.; Прочие: боли в костях и очагах поражения, повышение температуры тела.
Передозировка
Острая передозировка тамоксифеном у человека не наблюдалась. ; Симптомы: следует ожидать, что передозировка может вызвать усиление вышеописанных побочных реакций. ; Лечение: специфических антидотов не существует, лечение должно быть симптоматическим.
Особые указания
С осторожностью применяют при лейкопении, тромбоцитопении, гиперкальциемии, у пациентов с катарактой, гиперлипидемией.; В процессе лечения следует регулярно контролировать картину периферической крови (особенно количество тромбоцитов); уровень кальция и глюкозы в крови; при длительном применении показано наблюдение окулиста (каждые 3 мес).; Не следует сочетать с препаратами, содержащими гормоны, особенно эстрогены.; При одновременном применении с препаратами, оказывающими влияние на свертывающую систему крови, необходима коррекция дозы тамоксифена.; В экспериментальных исследованиях установлено канцерогенное действие тамоксифена.
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