Синтетический аналог природного ГнРГ. Бусерелин конкурентно... Инструкция
Показания к применению
Гормонозависимый рак предстательной железы, рак молочной железы, эндометриоз (пред- и послеоперационный периоды), миома матки, гиперпластические процессы эндометрия, лечение бесплодия (при проведении программы экстракорпорального оплодотворения).
Противопоказания
Беременность, период лактации, повышенная чувствительность к компонентам препарата.
Назальный дозированный спрей Бусерелин - противоопухолевое средство, синтетический аналог природного гонадотропин-рилизинг гормона (ГнРГ). Конкурентно связывается с рецепторами клеток передней доли гипофиза, вызывая кратковременное повышение уровня половых гормонов в плазме крови.
Фармакологические свойства
Синтетический аналог природного ГнРГ. Бусерелин конкурентно связывается с рецепторами клеток передней доли гипофиза, вызывая кратковременное повышение уровня половых гормонов в плазме крови. Применение в терапевтических дозах в течение 12-14 дней приводит к полной блокаде гонадотропной функции гипофиза, ингибируя, таким образом, выделение ЛГ и ФСГ. В результате происходит подавление синтеза половых гормонов, что проявляется снижением концентрации эстрадиола в плазме крови до постклимактерических значений у женщин и снижением содержания тестостерона до посткастрационного уровня у мужчин. Концентрация тестостерона при непрерывном применении бусерелина в течение 14-21 дней уменьшается до уровня, характерного для состояния орхиэктомии, т.е. вызывает фармакологическую кастрацию.
Показания к применению
Гормонозависимый рак предстательной железы, рак молочной железы, эндометриоз (пред- и послеоперационный периоды), миома матки, гиперпластические процессы эндометрия, лечение бесплодия (при проведении программы экстракорпорального оплодотворения).
Противопоказания
Беременность, период лактации, повышенная чувствительность к компонентам препарата.
Применение при беременности и в период грудного вскармливания
Противопоказан при беременности, в период лактации.
Способ применения и дозы
При лечении эндометриоза, миомы матки, гиперпластических процессов эндометрия препарат вводят в носовые ходы после их очищения в дозе 900 мкг/сут. Разовая доза препарата при полном нажатии помпы составляет 150 мкг. Суточную дозу препарат вводят равными порциями по одному впрыскиванию в каждый носовой ход 3 раза/сут через равные промежутки времени (6-8 ч) утром, днем и вечером. Лечение препаратом Бусерелин следует начинать в первый или второй день менструального цикла. При лечении бесплодия методом экстракорпорального оплодотворения препарат назначают в дозе 600 мкг/сут, т.е. по одному впрыскиванию 150 мкг в носовой ход 4 раза/сут через равные промежутки времени. Препарат вводят с середины лютеиновой фазы менструального цикла (с 21-24 дня цикла) до дня введения овуляторной дозы хорионического гонадотропина. На этом фоне при достижении блокады синтеза эстрадиола (Е2) со 2-5 дня менструальноподобного кровотечения по стандартным схемам осуществляется стимуляция препаратами гонадотропинов. При выраженной блокаде репродуктивной системы и слабом ответе яичников на стимуляцию овуляции препаратами гонадотропинов суточную дозу препарата Бусерелин следует уменьшить до 2 впрыскиваний в сут или увеличить дозу гонадотропинов. Повторный курс лечения проводится только по назначению врача и после медицинского обследования под динамическим контролем гормонального профиля и ультразвуковым мониторингом.
Побочное действие
Возможно: крапивница, гиперемия кожи, у женщин - частая смена настроения, нарушения сна, депрессия, головная боль, приливы, повышенное потоотделение, сухость влагалища, снижение либидо, боли внизу живота, деминерализация костей, у мужчин - гинекомастия. Редко: ангионевротический отек, у женщин - менструальноподобное кровотечение, у мужчин - оссалгия, задержка мочеиспускания, отеки почечного генеза, мышечная слабость в нижних конечностях, лимфостаз. В единичных случаях: причинно-следственная связь не установлена - тромбозы, диспептические симптомы.
Передозировка
В настоящее время о случаях передозировки препарата Бусерелин на сообщалось.
Особые указания
С осторожностью следует применять бусерелин у пациентов, занимающихся потенциально опасными видами деятельности, требующими повышенного внимания и высокой скорости психомоторных реакций.
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