Витамин Е является антиоксидантным средством, участвует в процессах пролиферации клеток, тканевого метаболизма, предупреждает гемолиз эритроцитов, препятствует повышенной проницаемости и ломкости капилляров.
Препарат препятствует развитию атеросклероза, дегенеративно-дистрофических изменений в сердечной мышце и скелетной мускулатуре, улучшает питание и сократительную способность миокарда, снижает потребление миокардом кислорода. Тормозит свободнорадикальные реакции, предупреждает образование пероксидов, повреждающих клеточные и субклеточные мембраны. Стимулирует синтез гема и гемсодержащих ферментов - гемоглобина, миоглобина, цитохромов, каталазы, пероксидазы.
Участвует в метаболизме нуклеиновых кислот и простагландинов, в клеточном дыхательном цикле, в синтезе арахидоновой кислоты.
При отсутствии витамина Е в организме (авитаминозе Е) развиваются дегенеративные изменения в скелетных мышцах сердца, повышается проницаемость и ломкость капилляров, перерождается эпителий семенных канальцев, яичек. У эмбрионов возникают кровоизлияния, наступает их внутриутробная гибель. Установлены также дегенеративные изменения в нервных клетках и поражение паренхимы печени.
При недостаточности витамина Е наблюдается снижение концентрации белков в сыворотке крови и содержания нуклеиновых кислот в печени и семенниках.
Недостаточность витамина Е у человека может быть связана с особенностями питания (например, отсутствием в пище растительных жиров) либо обусловлена различными заболеваниями, например, печени, поджелудочной железы и др.
Фармакокинетика.
Из ЖКТ всасывается примерно 50 % введенной дозы, максимальный уровень в крови создается через 4 часа. Для абсорбции необходимо наличие желчных кислот, жиров, нормальной функции поджелудочной железы. В процессе всасывания образует комплекс с липопротеидами, являющимися внутриклеточными переносчиками витамина Е. Поступает, главным образом, в лимфу, затем – в общий кровоток, где связывается в основном с альфа1 и бета-липопротеидами, частично с сывороточным альбумином. При нарушении обмена белков транспорт затрудняется. Депонируется во всех органах и тканях, особенно в жировой ткани.
Подвергается метаболизму в печени до производных, имеющих хиноновую структуру (некоторые из них обладают витаминной активностью). Выводится с желчью (свыше 90 %) и мочой (около 6 %) в неизмененном виде и в виде метаболитов.
Проникает через плаценту в недостаточных количествах: в кровь плода проникает 20 – 30 % от концентрации в крови матери. Проникает в грудное молоко.
Показания к применению
бесплодие,
гипогонадизм,
угрожающий аборт,
климакс,
дисменорея;
атрофия слизистой дыхательных путей,
астенический и невротический синдромы,
переутомление,
ревматические заболевания,
мышечная дистрофия,
парезы,
миопатия,
миастения,
фиброзиты,
тендопатии,
заболевания суставов и позвоночника,
тиреотоксикоз,
нарушение функции половых желез у мужчин,
дистрофия новорожденных,
недостаточное питание,
синдром мальабсорбции,
анемии,
хронический гепатит,
пародонтопатии,
поражения кожи и слизистых половых органов,
склеродермия,
красный плоский лишай.
Противопоказания
гиперчувствительность;
острый инфаркт миокарда;
детский возраст до 12 лет.
Способ применения и дозы
Внутрь. При бесплодии, угрожающем аборте — 200–300 мг/сут, при нарушениях менструального цикла (дополнение к гормональной терапии) — по 300–400 мг каждый 2-й день, повторяя 5 раз, начиная с 17-го дня цикла.
При климактерических нарушениях — по 100 мг 3 раза в сутки. При нарушениях менструального цикла в молодом возрасте до начала гормональной терапии — по 100–200 мг 1–2 раза в сутки в течение 2–3 мес.
При ревматических заболеваниях — по 100–300 мг в течение нескольких недель.
При неврастении — 100 мг/сут, при первичной мышечной дистрофии — до 2 г/сут, при других неврологических заболеваниях — 300 мг/сут.
При сосудистых заболеваниях — 100 мг/сут.
При эндокринных заболеваниях — 300–500 мг/сут.
При анемии в результате недостаточности питания — 300 мг/сут в течение 10 дней.
При хронических гепатитах — 300 мг/сут длительное время.
При пародонтопатии — 200–300 мг/сут.
При болезни Пестрони — 300–400 мг/сут в течение нескольких недель, затем по 50 мг в течение нескольких месяцев; при других заболеваниях кожи — 100–200 мг/сут, при необходимости и больше.
Побочное действие
диспептические расстройства,
снижение работоспособности,
слабость,
тромбозы,
тромбофлебиты,
тромбоэмболия легких,
повышение активности креатинкиназы,
креатинурия,
гиперхолестеринемия,
рост белых волос на участках алопеции при пузырчатом эпидермолизе.
Особые указания
Необходимо строго соблюдать режим дозирования.
Диета с повышенным содержанием селена и серосодержащих аминокислот снижает потребность в витамине Е.
При врожденном буллезном эпидермолизе в местах, пораженных аллопецией, могут начать расти белые волосы.
При длительном применении препарата и/или необходимости назначения повторных курсов терапии рекомендуется периодически контролировать показатели свертывания крови, а также уровень холестерина в крови.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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При нарушениях менструального цикла в молодом возрасте до начала гормональной терапии — по 100–200 мг 1–2 раза в сутки в течение 2–3 мес."}},{"type":"paragraph","data":{"text":"При ревматических заболеваниях — по 100–300 мг в течение нескольких недель."}},{"type":"paragraph","data":{"text":"При неврастении — 100 мг/сут, при первичной мышечной дистрофии — до 2 г/сут, при других неврологических заболеваниях — 300 мг/сут."}},{"type":"paragraph","data":{"text":"При сосудистых заболеваниях — 100 мг/сут."}},{"type":"paragraph","data":{"text":"При эндокринных заболеваниях — 300–500 мг/сут."}},{"type":"paragraph","data":{"text":"При анемии в результате недостаточности питания — 300 мг/сут в течение 10 дней."}},{"type":"paragraph","data":{"text":"При хронических гепатитах — 300 мг/сут длительное время."}},{"type":"paragraph","data":{"text":"При пародонтопатии — 200–300 мг/сут."}},{"type":"paragraph","data":{"text":"При болезни Пестрони — 300–400 мг/сут в течение нескольких недель, затем по 50 мг в течение нескольких месяцев; при других заболеваниях кожи — 100–200 мг/сут, при необходимости и больше."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"list","data":{"style":"ordered","items":["диспептические расстройства,","снижение работоспособности,","слабость,","тромбозы,","тромбофлебиты,","тромбоэмболия легких,","повышение активности креатинкиназы,","креатинурия,","гиперхолестеринемия,","рост белых волос на участках алопеции при пузырчатом эпидермолизе."]}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо строго соблюдать режим дозирования."}},{"type":"paragraph","data":{"text":"Диета с повышенным содержанием селена и серосодержащих аминокислот снижает потребность в витамине Е."}},{"type":"paragraph","data":{"text":"При врожденном буллезном эпидермолизе в местах, пораженных аллопецией, могут начать расти белые волосы."}},{"type":"paragraph","data":{"text":"При длительном применении препарата и/или необходимости назначения повторных курсов терапии рекомендуется периодически контролировать показатели свертывания крови, а также уровень холестерина в крови."}}]}],"source":null},"description_toggle":false,"short_description":"Витамин Е является антиоксидантным средством, участвует в процессах пролиферации клеток, тканевого метаболизма, предупреждает гемолиз эритроцитов, препятствует повышенной проницаемости и ломкости капилляров. 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