Селективный и конкурентный ингибитор ГМГ-КоА-редуктазы — фер... Инструкция
Показания к применению
Первичная гиперхолестеринемия (тип На по Фредриксену, включая семейную гетерозиготную гиперхолестеринемию) или смешанная гиперхолестеринемия (тип ИЬ) в качестве дополнения к диете, когда диета и другие немедикаментозные методы лечения (например, физические упражнения, снижение массы тела) оказываются недостаточными.- Гомозиготная наследственная гиперхолестеринемия в качестве дополнения к диете и другим методам лечения, направленным на снижение уровня липидов в крови (например, аферез ЛПНП), а также в случаях, когда эти методы недостаточно эффективны. Гипертриглицеридемия (тип IV по Фредриксону) в качестве дополнения к диете.- Для замедления прогрессирования атеросклероза в качестве дополнения к диете у пациентов, в том числе, которым показана терапия для снижения уровня общего Хс и Хс-ЛПНП.
Противопоказания
Повышенная чувствительность к розувастатину и другим компонентам препарата, заболевания печени в активной фазе, включая стойкое повышение сывороточной активности трансаминаз или повышение активности трансаминаз в сыворотке крови более чем в 3 раза по сравнению с ВГН, тяжелые нарушения функции почек (Cl креатинина менее 30 мл/мин), миопатия, одновременный ...
Таблетки Розулип - лекарственный препарат для снижения концентрации холестирина при атеросклерозе и других сердечно-сосудистых заболеваниях. Лечение Розулином не дает моментального эффекта – его действие становится заметно к исходу первой недели применения, а максимальный эффект достигается к исходу первого месяца терапии.
Фармакологические свойства
Селективный и конкурентный ингибитор ГМГ-КоА-редуктазы — фермента, катализирующего преобразование ГМГ-КоА в мевалонат, который является предшественником холестерина (Хс). Розувастатин увеличивает количество рецепторов ЛПНП на поверхности клеток печени, за счет чего усиливается поглощение и катаболизм ЛПНП, а также подавляется синтез ЛПОНП в печени. В результате снижается общее количество частиц ЛПОНП и ЛПНП. Снижает повышенную концентрацию Хс-ЛПНП, общего Хс и триглицеридов, а также повышает концентрацию Хс-ЛПВП. Кроме того, розувастатин снижает концентрацию аполипопротеина В (АпоВ), Хс-неЛПВП, Хс-ЛПОНП, триглицеридов ЛПОНП (ТГ-ЛПОНП) и увеличивает содержание аполипопротеина A-I (АпоА-I). Также розувастатин снижает соотношение Хс-ЛПНП/Хс-ЛПВП, общий Хс/Хс-ЛПВП, Хс-неЛПВП/Хс-ЛПВП и АпоВ/АпоА-I. Терапевтический эффект проявляется в течение одной недели после начала лечения. За 2 нед терапии эффективность достигает 90% от максимально возможной. Максимальный терапевтический эффект обычно достигается к 4-й неделе терапии и поддерживается при регулярном риеме.
Показания к применению
Первичная гиперхолестеринемия (тип На по Фредриксену, включая семейную гетерозиготную гиперхолестеринемию) или смешанная гиперхолестеринемия (тип ИЬ) в качестве дополнения к диете, когда диета и другие немедикаментозные методы лечения (например, физические упражнения, снижение массы тела) оказываются недостаточными.- Гомозиготная наследственная гиперхолестеринемия в качестве дополнения к диете и другим методам лечения, направленным на снижение уровня липидов в крови (например, аферез ЛПНП), а также в случаях, когда эти методы недостаточно эффективны. Гипертриглицеридемия (тип IV по Фредриксону) в качестве дополнения к диете.- Для замедления прогрессирования атеросклероза в качестве дополнения к диете у пациентов, в том числе, которым показана терапия для снижения уровня общего Хс и Хс-ЛПНП.
Противопоказания
Повышенная чувствительность к розувастатину и другим компонентам препарата, заболевания печени в активной фазе, включая стойкое повышение сывороточной активности трансаминаз или повышение активности трансаминаз в сыворотке крови более чем в 3 раза по сравнению с ВГН, тяжелые нарушения функции почек (Cl креатинина менее 30 мл/мин), миопатия, одновременный прием циклоспорина, предрасположенность к развитию миотоксических осложнений, непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция (препарат содержит лактозу).
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Внутрь, не разжевывать и не измельчать таблетку, проглатывать целиком, запивая водой. Можно принимать в любое время суток, независимо от приема пищи. Перед началом лечения пациенту необходимо назначить стандартную диету с низким содержанием Хс на весь период терапии. Дозу препарата следует подбирать индивидуально, в зависимости от показаний и терапевтического ответа на лечение, принимая во внимание текущие рекомендации по целевым уровням липидов.
Лечение: специфического антидота нет. Рекомендуется проводить симптоматическую терапию и мероприятия, направленные на поддержание функций жизненно важных органов и систем. Необходим контроль функции печени и уровня КФК в сыворотке крови. Эффективность гемодиализа маловероятна.
Особые указания
После 2–4 нед терапии и/или при повышении дозы препарата Розулип необходим контроль показателей липидного обмена, при необходимости требуется коррекция дозы.
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